Abstract: The invention provides novel pyridylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and X are as defined in the specification.

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: The invention provides novel pyridinamine-pyridone and pyrimidinamine-pyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders, autoimmune diseases and viral infections; wherein R1, R2, R3 and Z are as defined in the specification.

Abstract: The invention relates to a method for operating an internal combustion engine system (2), wherein the internal combustion engine system (2) is provided with an air intake duct (3), an exhaust gas duct (4) and an exhaust gas recirculation (EGR) system (5), wherein the EGR system (5) comprises an EGR conduit (6) that fluidly connects the exhaust duct (4) and the intake duct (3), and wherein a gas feeding device (7) configured to feed exhaust gas from the exhaust duct (4) to the intake duct (3) is arranged in the EGR conduit (6). The method is characterized in that it comprises the step of: detecting an indication of accumulated deposits of soot, hydrocarbons or other contaminants in the gas feeding device (7) by determining whether a rotational friction of a rotary member (71, 72) of the gas feeding device (7) exceeds a threshold value.

Abstract: The invention relates to a method for operating an internal combustion engine system (2), wherein the internal combustion engine system (2) is provided with an air intake duct (3), an exhaust gas duct (4) and an exhaust gas recirculation (EGR) system (5), wherein the EGR system (5) comprises an EGR conduit (6) that fluidly connects the exhaust duct (4) and the intake duct (3), and wherein a gas feeding device (7) configured to feed exhaust gas from the exhaust duct (4) to the intake duct (3) is arranged in the EGR conduit (6). The method is characterized in that it comprises the step of: providing a flushing liquid in the EGR conduit (6) upstream of the EGR gas feeding device (7) so as to flush and clean the EGR gas feeding device (7). The invention also relates to an internal combustion engine system (2) configured for being operated by such a method and to a vehicle (1) provided with such an engine system (2). The invention further relates to means for controlling the above method.

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.

Abstract: Provided herein is internal combustion engine system including: an internal combustion engine; a turbocharger turbine operatively connected to a turbocharger compressor; an air intake system; an exhaust gas system; an exhaust gas recirculation (EGR) conduit; an EGR valve; and a turbomachine arranged in the EGR conduit. Further, the EGR valve and the turbomachine are positioned in relation to each other in the EGR conduit such that a flow of high pressure exhaust gas through the EGR conduit towards the air intake system reaches the EGR valve before reaching the turbomachine; an additional exhaust gas conduit is arranged between the EGR conduit and a point of the exhaust system downstream the turbocharger turbine so as to allow exhaust gas to flow.

Abstract: The present invention relates to a method for controlling an internal combustion engine arrangement (100) connected to an exhaust gas aftertreatment system (200), wherein the method is arranged to control a gas heating device ( 122), as well as a gas feeding arrangement to direct a flow of intake air through the exhaust gas recirculation conduit (112) from the intake system to the exhaust system, the flow of intake air being directed through the gas heating device before the intake air enters the exhaust gas aftertreatment system, in response to determining a requested start of the internal combustion engine to heat the aftertreatment system before starting the engine.

Abstract: The invention provides novel pyridylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and X are as defined in the specification.

Abstract: The invention provides novel pyridinamine-pyridone and pyrimidinamine-pyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders, autoimmune diseases and viral infections; (I) wherein R1, R2, R3 and Z are as defined in the specification.

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: The invention relates to a method for operating an internal combustion engine system (2), wherein the internal combustion engine system (2) is provided with an air intake duct (3), an exhaust gas duct (4) and an exhaust gas recirculation (EGR) system (5), wherein the EGR system (5) comprises an EGR conduit (6) that fluidly connects the exhaust duct (4) and the intake duct (3), and wherein a gas feeding device (7) configured to feed exhaust gas from the exhaust duct (4) to the intake duct (3) is arranged in the EGR conduit (6). The method is characterized in that it comprises the step of: providing a flushing liquid in the EGR conduit (6) upstream of the EGR gas feeding device (7) so as to flush and clean the EGR gas feeding device (7). The invention also relates to an internal combustion engine system (2) configured for being operated by such a method and to a vehicle (1) provided with such an engine system (2). The invention further relates to means for controlling the above method.

Abstract: The invention relates to an internal combustion engine comprising a crankshaft, one or more cylinders including a cylinder head, a piston, a combustion chamber, one or more intake valves, one or more exhaust valves, an intake system configured for feeding intake air to the engine, an exhaust system configured for conveying exhaust gas away from the engine, a pressure charging system connected to the intake system and an exhaust gas recirculation (EGR) system arranged to feed branched off exhaust gas from the exhaust system to the intake system via an EGR conduit wherein: * the internal combustion engine includes a valve actuation device configured to allow for late or early closing of the intake valves in accordance with late or early Miller-type valve timing, and wherein * the EGR system includes a gas feeding device configured to feed exhaust gas through the EGR conduit in modes of operation wherein the pressure in the intake system exceeds the pressure in the exhaust system, * wherein the gas feeding devic

Abstract: The invention provides novel 6-aryl or 6-heteroaryl 4-morpholin-4-yl-pyhdine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory diseases, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and R4 are as defined in the specification.

Abstract: The invention relates to an internal combustion engine comprising a crankshaft, one or mor cylinders including a cylinder head, a piston, a combustion chamber, one or more intake valves, one or more exhaust valves, an intake system configured for feeding intake air to the engine, an exhaust system configured for conveying exhaust gas away from the engine, a pressure charging system connected to the intake system and an exhaust gas recirculation (EGR) system arranged to feed branched off exhaust gas from the exhaust system to the intake system via an EGR conduit wherein:—the internal combustion engine includes a valve actuation device configured to allow for late or early closing of the intake valves in accordance with late or early Miller-type valve timing, and wherein—the EGR system includes a gas feeding device configured to feed exhaust gas through the EGR conduit in modes of operation wherein the pressure in the intake system exceeds the pressure in the exhaust system.

Abstract: The present invention relates to a system and a method for achieving consensus between multiple parties (A, B, C) on an event and/or order of events (1 . . . 5) at high speed by verifying and voting on events by creating a voting event referencing one or multiple other events individually or as a group of events.

Abstract: The invention relates to a method for controlling an internal combustion engine system (2), wherein the internal combustion engine system (2) is provided with an air intake duct (3), an exhaust gas duct (4) and an exhaust gas recirculation (EGR) system (5), wherein the EGR system (5) comprises an EGR conduit (6) that fluidly connects the exhaust duct (4) and the intake duct (3), and wherein a gas feeding device (7) is arranged in the EGR conduit (6), said gas feeding device (7) being configured to feed exhaust gas from the exhaust duct (4) to the intake duct (3) during operation of the engine system (2). The method is characterized in that it comprises the step of: detecting a risk of freezing of condensed water in the EGR conduit (6), and, in case such a risk is detected and in case the gas feeding device (7) is not in operation, operating the gas feeding device (7).

Abstract: The invention relates to a method for operating an internal combustion engine system (2), wherein the internal combustion engine system (2) is provided with an air intake duct (3), an exhaust gas duct (4) and an exhaust gas recirculation (EGR) system (5), wherein the EGR system (5) comprises an EGR conduit (6) that fluidly connects the exhaust duct (4) and the intake duct (3), and wherein a gas feeding device (7) configured to feed exhaust gas from the exhaust duct (4) to the intake duct (3) is arranged in the EGR conduit (6). The method is characterized in that it comprises the step of: detecting an indication of accumulated deposits of soot, hydrocarbons or other contaminants in the gas feeding device (7) by determining whether a rotational friction of a rotary member (71, 72) of the gas feeding device (7) exceeds a threshold value.

Abstract: The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

Abstract: The invention relates to a method (100) for operating an internal combustion engine (2), such as an internal combustion engine of a vehicle (1), the engine (2) comprising an engine cylinder (3) at least partly defining a combustion chamber (4) and a reciprocating piston (5), a number of inlet valves (20) in fluid communication with the combustion chamber and a number of exhaust valves (30) in fluid communication with the combustion chamber, wherein any one of the inlet valves and the outlet valves comprises at least one flow control valve.