Abstract: In a robot system including at least two manipulators with a common work area, a method for optimizing a work cycle having the steps of: defining a layout; and dividing the common work area between the at least two manipulators to thereby obtain a work area division. At least one of the previous steps is repeated to thereby obtain a plurality of different combinations of layouts and work area divisions. For each of the plurality of combinations, a cycle time for at least one work cycle is calculated. By calculating cycle times for work cycles on different combinations of layouts and work area divisions, the work area division becomes part of the optimization problem and a better optimized work cycle can be achieved.