Patents by Inventor Freya de los Milagros Almeida

Freya de los Milagros Almeida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific antibody fragments for the human carcinoembryonic antigen (cea)
    Publication number: 20050158322
    Abstract: The invention refers to mono- and divalent (diabody) single chain Fv (scFv) antibody fragments, obtained by recombinant DNA techniques from the anti-carcinoembryonic antigen (CEA) monoclonal antibody (Mab) CB/ior-CEA.1. This antibody has high affinity for CEA and is employed in the diagnosis and follow-up of human colorectal tumors. As the original Mab, the monovalent fragment and the diabody exhibit high affinity for human CEA and recognize an epitope dependent of carbohydrate conservation. The monovalent scFv fragment and the diabody have affinity constants for CEA of (5.0±0.4)×109 L mol?1 and (2.8±0.3)×1010 L mol?1, respectively. These two fragments do not show cross reactivity with human normal cells and tissues, exception made of the normal colonic mucosa, where CEA is occasionally present.
    Type: Application
    Filed: April 28, 2003
    Publication date: July 21, 2005
    Inventors: Jorge Gailondo Cowley, Marta Avila, Freya de los Milagros Almeida, Boris Ernesto Castro, Hanssel Garcia, Lourdes Tatiana Navarro, Luis Javier Lopez, Jose Alberto Alvarez, Raquel Segui