Patents by Inventor Fridl Lang
Fridl Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9952234Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.Type: GrantFiled: December 11, 2015Date of Patent: April 24, 2018Assignee: Roche Diagnostics Operations, Inc.Inventors: Martin Horstmann, Fridl Lang
-
Patent number: 9429586Abstract: An automatic analyzer includes: first reagent storing means for storing a plurality of the reagent containers; second reagent storing means for storing a replacement reagent container in addition to the first reagent storing means; transfer means for transferring the reagent container from the second reagent storing means to the first reagent means; and a storing portion for storing the reagent container discharged from the second reagent storing means. The automatic analyzer includes control means for exercising control such that the information write means writes reagent information on the information recording medium immediately before the reagent container is transferred from the second reagent storing means to the first reagent storing means or immediately before the reagent container is discharged from the second reagent storing means to the storing portion.Type: GrantFiled: November 28, 2011Date of Patent: August 30, 2016Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations Inc.Inventors: Atsushi Watanabe, Shigeki Matsubara, Kazuhiro Shimada, Kenji Teshigawara, Osamu Matsumoto, Sylvia Rosenblatt, Peter Wolf, Fridl Lang, Roland Ihrig
-
Patent number: 9423412Abstract: Unlike conventional reagent storing means of an analyzing unit having a cold-storage function, replacement reagent storing means having no cold-storage function requires reagent management of a higher order. An automatic analyzer is provided that manages the placing elapsed time for a reagent vessel in replacement reagent storing means 2, compares the placing elapsed time for the reagent with a permissible placing limit value stored as one of analysis parameters for each analysis item, and determines as to whether or not the placing elapsed time exceeds permissible limit value. In this way, the analyzer prevents the degradation of the reagent and automatically transfers the reagent to an analyzing section for performing measurement.Type: GrantFiled: November 28, 2011Date of Patent: August 23, 2016Assignees: Hitachi High-Technologies Corporation, Roche Diagnostics Operations Inc.Inventors: Sayaka Sarwar, Shigeki Matsubara, Kenji Teshigawara, Emiko Suzuki, Osamu Matsumoto, Sylvia Rosenblatt, Peter Wolf, Fridl Lang, Roland Ihrig
-
Publication number: 20160097785Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.Type: ApplicationFiled: December 11, 2015Publication date: April 7, 2016Inventors: Martin Horstmann, Fridl Lang
-
Patent number: 6210975Abstract: The invention involves methods for determining analytes, and reagents for use in these methods. The methods and reagents use one or both of a polyvinyl/pyrolidone with a molecular weight of at least 360,000, and a polyethylene glycol with molecular weight of at least 40,000. The assays are carried out nephelometrically, or turbidometrically. The reagents include at least one antibody which binds the analyte. The hook effect is reduced or avoided in the practice of the invention.Type: GrantFiled: October 4, 1991Date of Patent: April 3, 2001Assignee: Roche Diagnostics GmbHInventors: Johann Karl, Fridl Lang
-
Patent number: 5817469Abstract: The invention concerns monoclonal antibodies which bind to the CK-MB isoenzyme but not to the B or M subunit of CK-MB or to the CK-MM and CK-BB isoenzmyes, as well as a method for the diagnostic detection of CK-MB in a homogeneous diagnostic test using these antibodies.Type: GrantFiled: October 30, 1995Date of Patent: October 6, 1998Assignee: Boehringer Mannheim GmbHInventors: Christa Hubner-Parajsz, Ulrich Essig, Fridl Lang, Rudolf Vogel
-
Patent number: 5565364Abstract: A method for the analysis of a component of a medical sample with the aid of an autoanalyzer, in which the sample is reacted with a reagent system and a physically measurable quantity X resulting from the reaction of the sample with the reagent system is measured in order to determine at least one measured value R for a specified sample and in which this at least one measured value R is further processed with the aid of a processing unit in a processing stage in order to determine an analytical result A. In the processing stage of the invention, use is made of the results of a neural net training, in which, for a number of standard samples for which the analytical result A is known, at least one measured value R, or a measurement result derived from several measured values R.sub.i, is applied to the input of a neural net.Type: GrantFiled: February 22, 1995Date of Patent: October 15, 1996Assignee: Boehringer Mannheim GmbHInventors: Rainer Schaefer, Bela Molnar, Christoph Berding, Peter Wolf, Fridl Lang
-
Patent number: 5420042Abstract: Method for the analytical determination of the concentration of a component of a medical sample, in which a reaction of the sample with reagents leads to a time-dependent change S(t) in a measured quantity S and the concentration C correlates according to an evaluation curve C(X) with an input variable X derived from S(t), in which the calibration curve is ambiguous for at least a portion of the possible X values. In order to assign an input variable X to one of the sub-sections and thereby to obtain an unambiguous correlation to a particular concentration C, a training run and an analysis run are performed. In the training run, a discrimination algorithm is performed at least once, in which a discriminator set is generated from measurements of S(t), a score is generated in each case from the latter with a multivariate statistical technique and it is checked whether the scores can be divided into separate subsets, in which the concentrations are correctly assigned to the sub-sections of the calibration curve.Type: GrantFiled: June 29, 1993Date of Patent: May 30, 1995Assignee: Boehringer Mannheim GmbHInventors: Rainer Schafer, Christoph Berding, Fridl Lang, Wilheim Kleider, Peter Wolf