Abstract: The present invention relates to methods of treating, delaying the onset of, slowing the progression of, or reducing the severity of age-related diseases by administering a compound of Formula 1 to a subject in need thereof. The invention further relates to methods of treating, delaying the onset of, slowing the progression of, or reducing the severity of premature aging disorders by administering a compound of Formula 1 to a subject in need thereof.

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

Abstract: The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

Abstract: The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.

Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

Abstract: Apparatuses and methods thereof to administer and manage a base unit for a handheld medical device are disclosed. In one embodiment, a base unit of the invention is in communication with a handheld medical device. The base unit is configured to provide an electrical connection to a power source to charge a battery of the handheld medical device. The base unit is also configured to perform an update to the operation of the base unit, wherein the update is initiated by the base unit upon receiving from the handheld medical device a data stream with information indicating that an update is contained in the data stream.

Abstract: The invention relates to the field of modular analytical systems. The invention enables the topology of a modular analytical system to be determined without requiring additional complicated measures such as a system reset. The method/system is also adapted to industry standards such that CAN-busses can be used.

Abstract: Apparatuses and methods thereof to administer and manage a base unit for a handheld medical device are disclosed. In one embodiment, a base unit of the invention is in communication with a handheld medical device. The base unit is configured to provide an electrical connection to a power source to charge a battery of the handheld medical device. The base unit is also configured to perform an update to the operation of the base unit, wherein the update is initiated by the base unit upon receiving from the handheld medical device a data stream with information indicating that an update is contained in the data stream.

Abstract: The invention relates to the field of modular analytical systems. The invention enables the topology of a modular analytical system to be determined without requiring additional complicated measures such as a system reset. The method/system is also adapted to industry standards such that CAN-busses can be used.

Abstract: The invention concerns an analytical system in which at least two modules are in contact with one another by a connecting plug, and a connecting plug which is suitable for connecting modules. When two modules are connected by the connecting plug a part of the plug extends partially underneath the bottoms of the modules such that the plug connection is secured by the dead weight of the modules.

Abstract: The invention concerns an analytical system in which at least two modules are in contact with one another by a connecting plug, and a connecting plug which is suitable for connecting modules. When two modules are connected by means of the connecting plug a part of the plug extends partially underneath the bottoms of the modules such that the plug connection is secured by to the dead weight of the modules.