Abstract: Various embodiments include a method for operating a vehicle based on a future speed curve along a predetermined travel route up to a specific preview horizon. The method may include: generating a prediction model; supplying data to the model; using an algorithm to generate a predicted speed profile; selecting a datum for the second input data group depending on a situation analysis using predetermined criteria; and using a controller to: implement operating strategies for a vehicle, control exhaust aftertreatment systems, increase an accuracy of navigation algorithms, and/or predict operating states depending on the speed forecast. The input data include a first input data group containing geocoordinates of the travel route and a second input data group containing at least one datum selected from the group consisting of: location information for a digital map, average traffic flow data along the travel route, and speed profiles of networked vehicles.

Abstract: A system for bridging a distance between two adjacent components is disclosed, the system including a first component and a second component arranged at a distance from the first component. The system further includes a bridging element arranged to bridge the distance between the first component and the second component. The bridging element may be elastic at least in certain regions and include a first region which is fastened to the first component. The bridging element further has a second region which has a first bearing surface extending towards the first component and a second bearing surface extending towards the second component. A thickness of the bridging element may be defined by the distance between the first contact surface and the second contact surface and selected such that the bridging element limits the distance to a minimum distance.

Abstract: Provided herein are methods of obtaining and expanding CD8+ enriched TILs. In some embodiments, the subject TILs are produced from tumor locations comprising CD8+ enriched TILs. Also provided herein are expansion methods for producing such CD8+ enriched TILs and methods of treatment using such TILs.

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CTLA-4 and PD-1 inhibitors and/or PD-L1 inhibitors as described herein.

Abstract: The present invention relates to a contactor device for high voltage applications, an energy storage system comprising the contactor device and a corresponding method for controlling the contactor device. A contactor device (100) comprises at least one fixed contact (106), at least one moveable contact (108), which is configured to move between an open position and a closed position, wherein in the closed position, the at least one moveable contact (108) electrically contacts the at least one fixed contact (106), and at least one first actuator (110, 120), which is configured to reversibly move the at least one moveable contact between the open position and the closed position. The contactor device (100) further comprises at least one second actuator (202) which is configured to move the at least one fixed contact (106) into a fired position, wherein in the fired position, the at least one fixed contact (106) is permanently disconnected from the at least one moveable contact (108).

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an anti-PD-1 antibody and/or anti-PD-L1 antibody and/or VEGF inhibitor, or wherein the NSCLC has a predetermined tumor proportion score (TPS).

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CTLA-4 and PD-1 inhibitors and/or PD-L1 inhibitors as described herein.

Abstract: A method for the manufacturing of an interior component for vehicles includes arranging a heating element in an injection mold and injecting a plastic melt into the injection mold in order to produce a base body. The heating element is disposed on a surface of the base body. The method further includes removing of the base body with the heating element from the injection mold after the plastic melt has solidified, and applying a cladding in order to clad the heating element and at least a part of the surface of the base body.

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of cancer with TILs in combination with CT-LA-4 and PD-1 inhibitors and/or PD-L1 inhibitors as described herein.

Abstract: Provided herein are methods for generating TILs that can then be employed in the treatment of patients having a cancer (e.g., a pediatric cancer, a uveal melanoma or mesothelioma).

Abstract: Various embodiments include a method for operating a vehicle based on a future speed curve along a predetermined travel route up to a specific preview horizon. The method may include: generating a prediction model; supplying data to the model; using an algorithm to generate a predicted speed profile; selecting a datum for the second input data group depending on a situation analysis using predetermined criteria; and using a controller to: implement operating strategies for a vehicle, control exhaust aftertreatment systems, increase an accuracy of navigation algorithms, and/or predict operating states depending on the speed forecast. The input data include a first input data group containing geocoordinates of the travel route and a second input data group containing at least one datum selected from the group consisting of: location information for a digital map, average traffic flow data along the travel route, and speed profiles of networked vehicles.

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an anti-PD-1 antibody and/or anti-PD-LI antibody and/or VEGF inhibitor, or wherein the NSCLC has a predetermined tumor proportion score (TPS).

Abstract: The present invention provides improved and/or shortened processes and methods for preparing TILs in order to prepare therapeutic populations of TILs with increased therapeutic efficacy for the treatment of non-small cell lung carcinoma (NSCLC), wherein the NSCLC is refractory to treatment with an anti-PD-1 antibody and/or anti-PD-L1 antibody and/or VEGF inhibitor, or wherein the NSCLC has a predetermined tumor proportion score (TPS).

Abstract: Various embodiments include methods for operating a motor vehicle during a journey along a route comprising: determining an upcoming potential stopping point along the route; upon approach to the potential stopping point, calculating a value for a probability of a stopping procedure of the motor vehicle at the stopping point at least in part on a stopping model; and, if the probability value is in a predetermined range of values defining a likely occurrence of the stopping procedure, triggering a predetermined operating measure to adapt operation of the motor vehicle to the stopping procedure. The stopping model includes a statistical model providing intermediate values between 0% and 100% for the probability value.

Abstract: The present invention relates to a contactor device for high voltage applications, an energy storage system comprising the contactor device and a corresponding method for controlling the contactor device. A contactor device (100) comprises at least one fixed contact (106), at least one moveable contact (108), which is configured to move between an open position and a closed position, wherein in the closed position, the at least one moveable contact (108) electrically contacts the at least one fixed contact (106), and at least one first actuator (110, 120), which is configured to reversibly move the at least one moveable contact between the open position and the closed position. The contactor device (100) further comprises at least one second actuator (202) which is configured to move the at least one fixed contact (106) into a fired position, wherein in the fired position, the at least one fixed contact (106) is permanently disconnected from the at least one moveable contact (108).

Abstract: A method for generating a visual range collection includes determining a current position of at least one motor vehicle, determining a current visual range which describes how far a driver of the motor vehicle can see from the current position, transmitting the visual range from the motor vehicle to a visual range collecting device, generating the visual range collection based on the transmitted visual range, predetermining an expected change in visual obstruction at the position, and adjusting the visual range from the visual range collection based on the predetermined change in visual obstruction.

Abstract: A system for bridging a distance between two adjacent components is disclosed, the system including a first component and a second component arranged at a distance from the first component. The system further includes a bridging element arranged to bridge the distance between the first component and the second component. The bridging element may be elastic at least in certain regions and include a first region which is fastened to the first component. The bridging element further has a second region which has a first bearing surface extending towards the first component and a second bearing surface extending towards the second component. A thickness of the bridging element may be defined by the distance between the first contact surface and the second contact surface and selected such that the bridging element limits the distance to a minimum distance.

Abstract: A method for operating a motor vehicle driver assistance apparatus, includes: capturing sensor data of a surrounding area of the motor vehicle in which at least one target vehicle is situated, the target vehicle being in front of and in the same lane as the motor vehicle; capturing at least one driver characteristic describing a driver of the motor vehicle; assigning the driver to a predetermined driver class based on the driver characteristic; reading in driver-class-specific overtaking information, describing an overtaking tendency of the driver, based on the driver class associated with the overtaking information; outputting a control signal of the driver assistance apparatus, which rates an overtaking maneuver of the motor vehicle in regard to the target vehicle, from a plurality of reference control signals having associated overtaking information based on the overtaking information and the sensor data; and outputting the control signal by the driver assistance apparatus.

Abstract: Method for operating a control device of a motor vehicle in order to predict a next stopping procedure, and control device and motor vehicle The invention relates to a method (23) for operating a control device (11) of a motor vehicle (10) during a journey along a route (16), wherein at least one upcoming potential stopping point (25, 32, 33, 34) along the route (16) is determined, and, as the respectively determined potential stopping point (25, 32, 33, 34) is approached, a probability value (28) for a probability of a stopping procedure of the motor vehicle (10) at the stopping point (25, 32, 33, 34) is determined on the basis of a stopping model (21).

Abstract: Various embodiments include a method for operating a motor vehicle using a collection of traffic information comprising: detecting a position of a first vehicle and a corresponding time; transmitting the position and time to an off-board collecting device; determining a future speed profile of the first vehicle; transmitting the future speed profile to the collecting device; generating the collection of traffic information based on the position, the time, and the future speed profile; transmitting the the collection of traffic information to a second vehicle; and operating the second vehicle based on the position, the time, and the future speed profile of the first vehicle.