Patents by Inventor Friedrich Hoffmeister
Friedrich Hoffmeister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4657924Abstract: A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.Type: GrantFiled: March 25, 1985Date of Patent: April 14, 1987Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Wolf-Dieter Busse, Friedrich Hoffmeister, Friedel Seuter, Elisabeth Perzborn, Klaus Schlossmann, Dieter Mayer, Volker Fiedler
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Patent number: 4552874Abstract: The invention relates to pyrazolooxazines, pyrazolothiazines and pyrazoloquinolines defined herein by Formula I. The invention also includes compositions containing said Formula I compounds and methods for the use of said compounds and compositions for their lipoxygenase-inhibiting properties. Also included in the invention are methods for the manufacture of said compounds of Formula I.Type: GrantFiled: February 1, 1983Date of Patent: November 12, 1985Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Rudolf Sundermann, Friedrich Hoffmeister, Wolf-Dieter Busse, Harald Horstmann, Siegfried Raddatz
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Patent number: 4540707Abstract: A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.Type: GrantFiled: April 18, 1983Date of Patent: September 10, 1985Assignee: Bayer AktiengesellschaftInventors: Mithat Mardin, Wolf-Dieter Busse, Friedrich Hoffmeister, Friedel Seuter, Elisabeth Perzborn, Klaus Schlossmann, Dieter Mayer, Volker Fiedler
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Patent number: 4406906Abstract: The invention provides pharmaceutical compositions and medicaments, useful for the treatment of cerebral disorders, wherein the active compound is 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(.beta.-methoxyethy l ester)-5-(isopropyl ester). Also included in the invention are methods for the use of said compositions and medicaments.Type: GrantFiled: February 5, 1982Date of Patent: September 27, 1983Assignee: Bayer AktiengesellschaftInventors: Horst Meyer, Friedrich Bossert, Stanislav Kazda, Friedrich Hoffmeister, Wulf Vater
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Patent number: 4187306Abstract: The invention covers compounds of the formula ##STR1## in which R.sup.1 and R.sup.5 each represents 0, 1, 2, 3 or 4 of the following substituents: alkyl, hydroxyl, acyloxy, alkoxy, nitro, amino, alkylamino, dialkylamino, acylamino, acylalkylamino, alkoxycarbonylamino, halogen, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulphonyl, alkylaminosulphonyl, dialkylaminoamino, R.sup.2 is hydrogen, optionally substituted alkyl, aralkyl or aryl or heterocyclo-alkyl, acyl or alkoxycarbonyl, and R.sup.3 and R.sup.4 are each hydrogen, or optionally substituted alkyl, aralkyl, aryl or hetero-aryl, are useful as medicaments which have an action on the central nervous system, in particular as, for example, tranquilizers and/or antiamnesics. Also included in the invention are methods for preparing said compounds, compositions containing them and methods for the use of said compounds and compositions.Type: GrantFiled: July 6, 1978Date of Patent: February 5, 1980Assignee: Bayer AktiengesellschaftInventors: Karl H. Mayer, Helmut Heitzer, Friedrich Hoffmeister, Arend Heise, Stanislav Kazda
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Patent number: 4110472Abstract: N-Diphenylmethyl and o-biphenylenemethyl derivatives of 1-(disubstituted phenoxy)-3-amino-2-hydroxypropane and their salts are useful for combatting cerebrovascular insufficiency and producing psychostimulation in humans and other animals. The compounds, of which 1-(2-methoxy-4-allylphenoxy)-2-hydroxy-3-diphenylmethylamino-propane is a typical embodiment, can be prepared by a number of synthetic routes.Type: GrantFiled: October 13, 1976Date of Patent: August 29, 1978Assignee: Bayer AktiengesellschaftInventors: Rudolf Hiltmann, Arend Heise, Stanislav Kazda, Friedrich Hoffmeister
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Patent number: 4070494Abstract: Enteral pharmaceutical compositions containing medicinal agents having parenteral abuse potential are rendered resistant to aqueous extraction through the incorporation of a sufficient amount of a nontoxic, water gelable material. Attempts to extract the medicinal agent for parenteral abuse are thus inhibited or prevented since the material gels in the presence of water leaving no filterable liquid.Type: GrantFiled: December 15, 1975Date of Patent: January 24, 1978Assignee: Bayer AktiengesellschaftInventors: Friedrich Hoffmeister, Rudolf Hiltmann, Hartmund Wollweber, Helmut Kramer
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Patent number: 4065568Abstract: 3-Hydrazinoindazoles acylated with a carbo(lower alkoxy) group in the 3-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-carbomethoxyhydrazino-6-chloroindazole is a typical embodiment, are prepared through treatment of the appropriate 3-hydrazinoindazole with a derivative of carbonic acid.Type: GrantFiled: November 24, 1975Date of Patent: December 27, 1977Assignee: Bayer AktiengesellschaftInventors: Karl Heinrich Mayer, Friedrich Hoffmeister, Wolfgang Wuttke
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Patent number: 4051252Abstract: 3-Aminoindazoles bearing a carbo(lower alkoxy), lower alkylamide or di(lower alkyl)amide group in the 1-or 2-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-amino-6-chloroindazole-1-carboxylic acid ethyl ester is a typical embodiment, are prepared through treatment of the appropriate 3-aminoindazole with a derivative of carbonic acid or through thermal isomerization.Type: GrantFiled: November 24, 1975Date of Patent: September 27, 1977Assignee: Bayer AktiengesellschaftInventors: Karl Heinrich Mayer, Siegfried Petersen, Erich Klauke, Friedrich Hoffmeister, Wolfgang Wuttke
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Patent number: 3989844Abstract: Oximes of the formula: ##SPC1##And their acid salts, wherein A is a branched or unbranched, saturated or unsaturated alkylene chain of 0-6 carbon atoms, B is a basic nitrogen-containing group such as an amino, alkylamino, dialkylamino, cycloalkylamino, dicycloalkylamino, cycloalkylalkylamino, dicycloalkylalkylamino, alkylarylamino, alkylaralkylamino, a piperidino, pyrrolidino, hexamethyleneimino, morpholino, thiomorpholino, N-alkylpiperazino or N-(2-hydroxyalkyl)-piperazino group, n is 1 or 2 and X is --CH.sub.2 --, --(CH.sub.2).sub.3 -- or --CH = CH--, and R.sub.1 and R.sub. 2 are each hydrogen, halogen, alkyl of 1-4 carbon atoms, alkoxy, alkylmercapto groups of 1-4 carbon atoms, hydroxyl, nitro, amino or trifluoromethyl, are useful for their anti-depressant activity. Pharmaceutical compositions may be prepared which comprise an anti-depressant amount of at least one such compound in combination with a pharmaceutically acceptable inert diluent or carrier.Type: GrantFiled: June 11, 1971Date of Patent: November 2, 1976Assignee: Bayer AktiengesellschaftInventors: Siegismund Schutz, Otto Behner, Friedrich Hoffmeister
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Patent number: 3963778Abstract: 1. A compound selected from the group consisting ofAnd pharmaceutically acceptable non-toxic acid salts thereof.Type: GrantFiled: July 14, 1969Date of Patent: June 15, 1976Assignee: Bayer AktiengesellschaftInventors: Siegismund Schutz, Otto Behner, Friedrich Hoffmeister
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Patent number: 3936463Abstract: Benzomorphanes of the formula: ##SPC1##WhereinR is cyclopropylmethyl or cyclobutylmethyl;R.sup.1 and R.sup.2 are the same or different and each is lower alkyl;R.sup.Type: GrantFiled: December 3, 1973Date of Patent: February 3, 1976Assignee: Bayer AktiengesellschaftInventors: Otto Behner, Ulrich Horlein, Friedrich Hoffmeister, Hans Werner Schubert