Patents by Inventor Friedrich Kroll

Friedrich Kroll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic-compounds for use as a medicament, in particular for treatment of parkinson's disease
    Patent number: 11008282
    Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: May 18, 2021
    Inventors: Hubert Koester, Lisa Von Kleist, Simon Michaelis, Kathrin Bartho, Marén Schlief, Mathias Dreger, Anna K. Schrey, Michael Sefkow, Friedrich Kroll, Daniel Ohlendorf, Yan Luo
  • NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE
    Publication number: 20180370906
    Abstract: The invention relates to novel small molecule compounds having a basic structure as depicted by formula (A), where in particular exemplary embodiments R1 is —OH, R2 is —NO2 and R3 is H, R4 and R5 are H, one of R6 and R7 is selected from H, —CONH2, and —CONR92, and the other one is selected from —CONR92 and —CONR11R9, wherein R9 and R11 are (possibly multiply) substituted alkyl and H or alkyl, respectively. The compounds of the invention inhibit the enzyme Catechol-O-methyltransferase (COMT) and exhibit a low off-target profile. The compounds are provided for use as a medicament, in particular for use in prevention or treatment of Parkinson's disease.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 27, 2018
    Inventors: Hubert KOESTER, Lisa VON KLEIST, Simon MICHAELIS, Kathrin BARTHO, Marén SCHLIEF, Mathias DREGER, Anna K. SCHREY, Michael SEFKOW, Friedrich KROLL, Daniel OHLENDORF, Yan LUO
  • 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence
    Patent number: 7678800
    Abstract: The present invention relates to 2-(1H-indolylsulfanyl)-aryl amine derivatives of the general formula I as the free base or salts thereof and their use for the treatment of affective disorders, pain, attention deficit hyperactivity disorder (ADHD) and stress urinary incontinence.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: March 16, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Jan Kehler, Friedrich Kroll, Karsten Juhl
  • 3,4-dihydro-1H-isoquinolin-2-yl-derivatives
    Patent number: 7384957
    Abstract: The present invention relates to novel compounds of formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof. The compounds of the invention are NK2 antagonists.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: June 10, 2008
    Assignee: H. Lundbeck A/S
    Inventors: Jan Kehler, Anders Poulsen, Berith Bjornholm, Friedrich Kroll, Morten Bang Norgaard
  • 2-(1H-Indolysulfanyl)-Aryl Amine Derivatives for Use in the Treatment of Affective Disorders, Pain, Adhd and Stress Urinary Incontinence
    Publication number: 20080027074
    Abstract: The present invention relates to aniline derivatives of the general formula I as the free base or salts thereof and their use.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 31, 2008
    Inventors: Jan Kehler, Friedrich Kroll, Karsten Juhl
  • 4-(2-Phenyloxyphenyl)-piperidine or-1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
    Publication number: 20060293360
    Abstract: The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
    Type: Application
    Filed: April 2, 2004
    Publication date: December 28, 2006
    Applicant: H. Lundbeck A/S
    Inventors: Benny Bang-Andersen, Friedrich Kroll, Jan Kehler
  • 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives
    Publication number: 20050070713
    Abstract: The present invention relates to novel compounds of formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof. The compounds of the invention are NK2 antagonists.
    Type: Application
    Filed: December 16, 2002
    Publication date: March 31, 2005
    Applicant: H. Lundbeck A/S
    Inventors: Jan Kehler, Anders Poulsen, Berith Bjornholm, Friedrich Kroll, Morten Norgaard