Patents by Inventor Friedrich Raulf

Friedrich Raulf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biomarkers for Graft Rejection
    Publication number: 20120039868
    Abstract: Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed in transplanted subjects.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 16, 2012
    Inventors: Marc Bigaud, Jeanne Kehren, Friedrich Raulf, Grazyna Wieczorek
  • Methods and compositions for assessing acute rejection
    Patent number: 7811767
    Abstract: The invention relates to the analysis and identification of genes that are up-regulated simultaneously in transplant rejection. This simultaneous up-regulation of genes provides a molecular signature to accurately detect transplant rejection.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: October 12, 2010
    Assignee: Novartis AG
    Inventors: Friedrich Raulf, Pierre Saint-Mezard, Hai Zhang
  • BIOMARKERS FOR GRAFT REJECTION
    Publication number: 20090269334
    Abstract: Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed in transplanted subjects.
    Type: Application
    Filed: July 13, 2009
    Publication date: October 29, 2009
    Inventors: Marc Bigaud, Jeanne Kehren, Friedrich Raulf, Grazyna Wieczorek
  • BIOMARKERS FOR ACUTE GRAFT REJECTION
    Publication number: 20090053195
    Abstract: Methods are disclosed for the early non-invasive diagnosing of acute rejection (AR) in a transplanted subject, monitoring AR in a transplanted subject at risk of developing AR, preventing, inhibiting, reducing or treating AR in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of AR, based on genes which are differentially expressed in peripheral blood or transplant biopsy tissues, before full clinical manifestation of AR is detected in the transplanted subject.
    Type: Application
    Filed: September 5, 2005
    Publication date: February 26, 2009
    Inventors: Friedrich Raulf, Lukas Roth, Johannes Voshol
  • METHODS AND COMPOSITIONS FOR ASSESSING ACUTE REJECTION
    Publication number: 20090022730
    Abstract: The invention relates to the analysis and identification of genes that are up-regulated simultaneously in transplant rejection. This simultaneous up-regulation of genes provides a molecular signature to accurately detect transplant rejection.
    Type: Application
    Filed: March 13, 2007
    Publication date: January 22, 2009
    Inventors: Friedrich Raulf, Pierre Saint-Mezard, Hai Zhang
  • Biomarkers for graft rejection
    Publication number: 20070111210
    Abstract: Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed in transplanted subjects.
    Type: Application
    Filed: December 2, 2004
    Publication date: May 17, 2007
    Inventors: Marc Bigaud, Jeanne Kehren, Friedrich Raulf, Grazyna Wieczorek
  • Vav inhibition in graft rejection
    Publication number: 20070042948
    Abstract: The present invention provides a method for preventing or treating acute or chronic graft rejection in a recipient of cell, tissue or organ allo- or xenotransplant, inflammatory or autoimmune diseases or malignant proliferative disease, comprising the use of an inhibitor of Vav. Further provided are Vav inhibitors, uses, pharmaceutical compositions and therapeutic combinations comprising Vav inhibitors, and screening methods therefore.
    Type: Application
    Filed: April 15, 2004
    Publication date: February 22, 2007
    Inventors: Michael Forstner, Martin Klumpp, Lukas Leder, Barbara Nusslein-Hildesheim, Friedrich Raulf, Gisbert Weckbecker
  • Diagnosis of chronic rejection
    Publication number: 20060099591
    Abstract: Methods are disclosed for, early diagnosing chronic rejection (CR) in a transplanted subject, monitoring CR in a transplanted subject at risk of developing CR, preventing, inhibiting, reducing or treating CR in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of CR, based on genes which are differentially expressed in transplant biopsy tissues, before any overt clinical or histological manifestation of CR is detected in the transplanted subject.
    Type: Application
    Filed: August 21, 2003
    Publication date: May 11, 2006
    Inventors: Andreas Krause, Detlef Niese, Friedrich Raulf, Andreas Scherer