Patents by Inventor Friedrich Rippmann

Friedrich Rippmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic amino acids
    Patent number: 6559144
    Abstract: Compounds of the formula I in which X, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meanings stated in claim 1, and their physiologically acceptable salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of circulatory disorders, for thrombosis, myocardial infarct, coronary heart disease, arteriosclerosis, osteoporosis, for pathological processes maintained or propagated by angiogenesis, and in tumour therapy.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: May 6, 2003
    Assignee: Merck Patent Gesellschaft Mit
    Inventors: Beate Diefenbach, Simon L. Goodman, Joachim März, Peter Raddatz, Friedrich Rippmann, Matthias Wiesner
  • Identification of human gaba transporter
    Publication number: 20030069398
    Abstract: Human GABA transporter and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing the new polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: September 24, 2002
    Publication date: April 10, 2003
    Inventors: Friedrich Rippmann, Klaus Ducker
  • Bicyclic amino acids
    Publication number: 20010021709
    Abstract: Compounds of the formula I 1
    Type: Application
    Filed: April 26, 2001
    Publication date: September 13, 2001
    Applicant: Merck Patent Gesellschaft mit Beschrankt Patents
    Inventors: Beate Diefenbach, Simon L. Goodman, Joachim Marz, Peter Raddatz, Friedrich Rippmann, Matthias Wiesner
  • Cyclic adhesion inhibitors
    Patent number: 6169072
    Abstract: The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-B-Asp-D-E)  I in which B, D, and E have the meanings defined herein, and their salts. These compounds act as interin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
    Type: Grant
    Filed: October 1, 1998
    Date of Patent: January 2, 2001
    Assignee: Merck Patent Gesellschaft Mit
    Inventors: Alfred Jonczyk, G{umlaut over (u)}nter Hölzemann, Brunhilde Felding-Habermann, Friedrich Rippmann, Beate Diefenbach, Horst Kessler, Roland Haubner, Jochen Wermuth
  • Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors
    Patent number: 5849692
    Abstract: The invention relates to novel cyclopeptides of the formula Icyclo-(Arg-B-Asp-D-E) Iin which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: December 15, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Alfred Jonczyk, Gunter Holzemann, Brunhilde Felding-Habermann, Friedrich Rippmann, Beate Diefenbach, Horst Kessler, Roland Haubner, Jochen Wermuth
  • Linear adhesion inhibitors
    Patent number: 5747457
    Abstract: Linear peptides of the formula IX-A-Cys(R.sup.1)-B-Z I,in whichA, B, R.sup.1, X and Z are as defined, are highly active inhibitors of the binding of the blood platelet integrin GP IIbIIIa (a.sub.IIb .beta..sub.3) to natural ligands and are suitable, inter alia, for the prophylaxis and for the treatment of circulatory disorders, thrombosis, myocardial infarction, coronary heart disease, arteriosclerosis, atherosclerosis, tumors and osteolytic diseases, and have a supporting effect in wound healing processes.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: May 5, 1998
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Alfred Jonczyk, Brunhilde Felding-Habermann, Beate Diefenbach, Friedrich Rippmann
  • Cyclopeptides
    Patent number: 5705481
    Abstract: The invention relates to novel cyclopeptides of the formula Icyclo-(A-B-C-D-Arg) Iin whichA and B are each independently of one another Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val;C is Asp or Asp(O--C.sub.1-4 -alkyl); andD is Gly or Ala;at least two of the amino acid radicals stated being present in the D-form;and their salts.These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: January 6, 1998
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Alfred Jonczyk, Gunter Holzemann, Brunhilde Felding-Habermann, Friedrich Rippmann, Guido Melzer, Beate Diefenbach