Patents by Inventor Fritz Bek
Fritz Bek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9297807Abstract: A kit for optically detecting proteins, in particular lipoproteins, in a sample, the kit comprising: a chip for performing a separation of the proteins, in particular of the lipoproteins, wherein the chip comprises at least one well for receiving the sample, and a separation channel coupled to the at least one well and being adapted for separating different compounds and a marker dye which contains a polymethine of the general formula (I) wherein Z is a substituted derivative of benzooxazole, benzodiazole, 2,3,3-trimethylindolinine, 2,3,3-trimethyl-4,5-benzo-3H-indolinine, 3- and 4-picoline, lipidine, chinadine and 9-methylacridine derivatives with the general formula IIa or IIb or IIc and wherein X is selected from the group consisting of O, S, Si, N-alkyl and C(alkyl)2, n is 0, 1 , 2 or 3, R1 to R14 are independently selected from the group consisting of hydrogen, alkyl, alkoxy, cycloalkyl, linear or branched alkenyl, cycloalkenyl, aryl, heteroaryl, heterocycle, hydroxy, carboxy, amine, alkyl-substituted amType: GrantFiled: February 10, 2006Date of Patent: March 29, 2016Assignee: Agilent Technologies, Inc.Inventors: Martin Kratzmeier, Xiaodan Tian, Fritz Bek
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Publication number: 20110290330Abstract: A method for removing fluid in a microfluidic device, the microfluidic device having a fluid channel, a first well, and a second well, the first well and the second well being coupled to a first end of the fluid channel, the method including applying a pressure difference between the second well and the first well, and applying a pressure difference between the first end and a second end of the fluid channel being below a certain threshold, for at least partly removing a first fluid from a first supply line coupled between the first well and the first end of the fluid channel.Type: ApplicationFiled: August 9, 2007Publication date: December 1, 2011Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Marcus Gassmann, Fritz Bek
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Publication number: 20100044231Abstract: A microfluidic chip (10) comprises a substrate (20) having a main side (30) and a lateral side (40), and a microfluidic channel (50, 60) within the substrate and being adapted to transport a fluid. The microfluidic channel has a lateral opening to the lateral side of the substrate allowing to introduce fluid to the microfluidic channel.Type: ApplicationFiled: January 17, 2007Publication date: February 25, 2010Applicant: AGILENT TECHNOLOGIES, INC.Inventors: Stefan Falk-Jordan, Hans-Peter Zimmermann, Fritz Bek
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Publication number: 20090230044Abstract: A method of cleaning a microfluidic chip (101) comprising at least one microstructure (105, 106) containing a material (111), wherein the method comprises removing the material (111) from the at least one microstructure (105, 106) so as to at least partly empty the at least one microstructure (105, 106).Type: ApplicationFiled: March 13, 2008Publication date: September 17, 2009Applicant: AGILENT TECHNOLOGIES, INC.Inventor: Fritz Bek
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Publication number: 20090200167Abstract: A kit for optically detecting proteins, in particular lipoproteins, in a sample, the kit comprising: a chip for performing a separation of the proteins, in particular of the lipoproteins, wherein the chip comprises at least one well for receiving the sample, and a separation channel coupled to the at least one well and being adapted for separating different compounds and a marker dye which contains a polymethine of the general formula (I) wherein Z is a substituted derivative of benzooxazole, benzodiazole, 2,3,3-trimethylindolinine, 2,3,3-trimethyl-4,5-benzo-3H-indolinine, 3- and 4-picoline, lipidine, chinadine and 9-methylacridine derivatives with the general formula IIa or IIb or IIc and wherein X is selected from the group consisting of O, S, Si, N-alkyl and C(alkyl)2, n is 0, 1 , 2 or 3, R1 to R14 are independently selected from the group consisting of hydrogen, alkyl, alkoxy, cycloalkyl, linear or branched alkenyl, cycloalkenyl, aryl, heteroaryl, heterocycle, hydroxy, carboxy, amine, alkyl-substituted amType: ApplicationFiled: February 10, 2006Publication date: August 13, 2009Inventors: Martin Kratzmeier, Xiaodan Tian, Fritz Bek
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Publication number: 20080311006Abstract: A fluid supply unit is described, with the fluid supply unit comprising a fluid dispenser with an orifice adapted for dispensing a fluid, and a microfluidic device comprising an inlet port located at one of the faces of the microfluidic device. The fluid supply unit is adapted for establishing a fluidic contact between a droplet formed at the fluid dispenser's orifice and an inlet port of the microfluidic device, and the fluid supply unit is adapted for electrophoretically moving charged compounds from the droplet towards the inlet port.Type: ApplicationFiled: August 29, 2007Publication date: December 18, 2008Inventors: Fritz Bek, Marcus Gassmann
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Publication number: 20070039823Abstract: A microfluidic system comprises a first reservoir, an injection channel fluidically coupled to the first reservoir and to an injection point adapted for injecting an amount of fluid, and a side channel fluidically coupled to the injection channel at an intersection point located between the first reservoir and the injection point, the side channel being fluidically coupled with a second reservoir. Both the injection channel and the side channel are at least partly filled with a first substance and the second reservoir is at least partly filled with a second substance. The first substance is a gel and the second substance is a buffer solution. The side channel's cross section is larger than the injection channel's cross section.Type: ApplicationFiled: May 30, 2006Publication date: February 22, 2007Inventors: Fritz Bek, Marcus Gassmann
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Patent number: 6660991Abstract: Low intensity light is incident upon a photodiode whose output is coupled to an integrator. The output of the integrator is coupled to an input of an A/D converter, whose output is coupled to a microprocessor, whose output is coupled to a filter. A second output of the microprocessor is coupled to a gate electrode of a FET to provide a reset signal to the FET to reset the integrator. The microprocessor compares the digital samples of the integrated signal from the A/D converter and, firstly, generates the reset signal if a sample is beyond a set limit, and, secondly, calculates delta values between adjacent samples and interpolates the delta values for the reset periods so as to provide a continuous data stream which can be filtered by a filter matched to the form of the original signal.Type: GrantFiled: March 11, 2002Date of Patent: December 9, 2003Assignee: Agilent Technologies, Inc.Inventors: Volker Brombacher, Fritz Bek
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Publication number: 20030025069Abstract: When low intensity light (4) is incident upon a photodiode (2), the output from the photodiode (2) is coupled to an integrator formed by an operational amplifier (7), a capacitor (8) and a FET coupled in parallel in a feedback path between an output (9) of the operational amplifier (7) and its negative input (5). The output (9) of the operational amplifier (7) is coupled to an input of an A/D converter (21), whose output is coupled to a microprocessor (22), whose output is coupled to a filter (23). A second output of the microprocessor (22) is coupled to a gate electrode of FET 10 to provide a reset signal to the FET 10 to reset the integrator.Type: ApplicationFiled: March 11, 2002Publication date: February 6, 2003Applicant: Agilent Technologies, Inc.Inventors: Volker Brombacher, Fritz Bek
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Patent number: 6264892Abstract: Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the methods of the invention include associated laser-ablated features required for function, such as on-device reservoirs or makeup flow compartments, analyte detection means and sample injection means. The miniaturized columns can be used in an apparatus intended for analysis of either small and/or macromolecular solutes in the liquid phase which employs chromatographic, electrophoretic or electrochromatographic separation means. The apparatus can include a variety of optional injection means, manifolds, keeper means, post column collection means, and combinations thereof.Type: GrantFiled: January 11, 2000Date of Patent: July 24, 2001Assignee: Agilent Technologies, Inc.Inventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 6093362Abstract: Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.Type: GrantFiled: February 11, 1999Date of Patent: July 25, 2000Assignee: Agilent Technologies, Inc.Inventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 6033628Abstract: In a method of forming a microchannel and/or microcavity structure by bonding together two elements (1, 2) having opposed plane surfaces of the same or different material, one or both surfaces having open channels and/or cavities, bonding is effected by applying to one or both element surfaces (1, 2) a thin layer (3) of a solution of a material capable of fusing with and having a lower melting point than that of the material or materials of the two element surfaces (1, 2) in a solvent which substantially does not dissolve the element surface material or materials. The solvent is then removed, and the two elements (1, 2) are brought together and heated to a temperature where the dissolved material is caused to melt but not the element surface material or materials.Type: GrantFiled: April 27, 1998Date of Patent: March 7, 2000Assignee: Agilent Technologies, Inc.Inventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 5882571Abstract: Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.Type: GrantFiled: March 27, 1997Date of Patent: March 16, 1999Assignee: Hewlett-Packard CompanyInventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 5804022Abstract: Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.Type: GrantFiled: August 18, 1997Date of Patent: September 8, 1998Assignee: Hewlett-Packard CompanyInventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 5785831Abstract: A method and apparatus for mixing liquids using electroosmotic flow. Multiple capillaries (100, 104, 106) or microchip channels meet at a common junction (102). One capillary (100) is used for mixed liquids and each of the remaining capillaries (104, 106) are used for supplying a liquid (112, 114) to be mixed. Each of the supply capillaries (104, 106) has a free end that is immersed into a vial (108, 110) of liquid (112, 114). A first power supply terminal (112) is attached to a free end of the mixed liquid capillary (100). The liquid in each vial has an electrode that is switchably connected to a second power supply terminal. Closing a switch (116, 118) causes liquid to flow from a vial through the common junction and through the mixed liquid capillary. Each switch is independent and each may be closed continuously, switched at a constant duty cycle, or switched at a variable duty cycle. As a result, continuous mixing or variable ratio mixing may be achieved.Type: GrantFiled: February 8, 1996Date of Patent: July 28, 1998Assignee: Hewlett-Packard CompanyInventor: Fritz Bek
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Patent number: 5658413Abstract: Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.Type: GrantFiled: June 7, 1995Date of Patent: August 19, 1997Assignee: Hewlett-Packard CompanyInventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: 5645702Abstract: A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are positioned along the elongate separation compartment. The elongate separation compartment has first and second opposing sides along its elongate dimension. Each set of antenna contains a plurality of antennas. One antenna from each set is associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on the opposing sides of the separation compartment. Each set of the antennas is associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along the elongate separation compartment toward an exit end of the separation compartment. The detector can detect a target substance passing out of the elongate separation compartment.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: Hewlett-Packard CompanyInventors: Klaus E. Witt, Patrick Kaltenbach, Fritz Bek, Sally A. Swedberg, Laurie S. Mittelstadt
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Patent number: 5641400Abstract: Miniaturized planar column devices and miniaturized total analysis systems for liquid phase analysis are disclosed. The systems include a temperature control device for regulating temperature, preferably a thermoelectric device comprising Peltier elements.Type: GrantFiled: October 23, 1995Date of Patent: June 24, 1997Assignee: Hewlett-Packard CompanyInventors: Patrick Kaltenbach, Sally A. Swedberg, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt
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Patent number: RE39527Abstract: Low intensity light is incident upon a photodiode whose output is coupled to an integrator. The output of the integrator is coupled to an input of an A/D converter, whose output is coupled to a microprocessor, whose output is coupled to a filter. A second output of the microprocessor is coupled to a gate electrode of a FET to provide a reset signal to the FET to reset the integrator. The microprocessor compares the digital samples of the integrated signal from the A/D converter and, firstly, generates the reset signal if a sample is beyond a set limit, and, secondly, calculates delta values between adjacent samples and interpolates the delta values for the reset periods so as to provide a continuous data stream which can be filtered by a filter matched to the form of the original signal.Type: GrantFiled: September 30, 2004Date of Patent: March 27, 2007Assignee: Agilent Technologies, Inc.Inventors: Volker Brombacher, Fritz Bek
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Patent number: RE36350Abstract: A miniaturized total analysis system (".mu.-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The .mu.-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The .mu.-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. .mu.-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.Type: GrantFiled: July 30, 1998Date of Patent: October 26, 1999Assignee: Hewlett-Packard CompanyInventors: Sally A. Swedberg, Patrick Kaltenbach, Klaus E. Witt, Fritz Bek, Laurie S. Mittelstadt