Patents by Inventor Fritz E. Gerhart

Fritz E. Gerhart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted ornithine derivatives
    Patent number: 4902719
    Abstract: This invention relates to ornithine derivatives substituted at the 5 position with an R group which can be a --CH.sub.2 F, --CHF.sub.2, --CHClF, --C.tbd.CH, --CH.dbd.CH.sub.2, or --CH.dbd.C.dbd.CH.sub.2 group and the pharmaceutically acceptable acid addition salts thereof which are specific inhibitors of OAT and can be used in the treatment of conditional deficiencies of ornithine.
    Type: Grant
    Filed: February 1, 1989
    Date of Patent: February 20, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Fritz E. Gerhart, Nikolaus J. Seiler
  • Process for preparing fluorinated amino-nitriles
    Patent number: 4405530
    Abstract: Certain .alpha.-(fluoromethyl or difluoromethyl)-.alpha.-aminoacetonitriles are prepared by treating the appropriate .alpha.-(fluoromethyl or difluoromethyl) ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyanide and a proton source. The products are useful as intermediates for making .alpha.-(fluoromethyl or difluoromethyl)-.alpha.-amino acids having pharmacological activity.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: September 20, 1983
    Assignee: Merrell Toraude et Compagnie
    Inventor: Fritz E. Gerhart