Patents by Inventor Fritz Grunert

Fritz Grunert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal anti-claudin 1 antibodies for the inhibition of hepatitis C virus infection
    Patent number: 8518408
    Abstract: The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: August 27, 2013
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), University de Strasbourg
    Inventors: Thomas Baumert, Catherine Schuster, John Thompson, Fritz Grunert
  • Monoclonal Anti-Claudin 1 Antibodies for the Inhibition of Hepatitis C Virus Infection
    Publication number: 20110236347
    Abstract: The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 29, 2011
    Applicants: GENOVAC, UNIVERSITE DE STRASBOURG, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Thomas Baumert, Catherine Schuster, John Thompson, Fritz Grunert