Abstract: A method for purifying a protected oligonucleotide comprising the steps of: a) providing a solution of the protected oligonucleotide in at least one solvent A having a boiling point below the boiling point of a solvent B, heating the solution at a temperature of at least 30° C. and below the boiling point of the at least solvent A, adding solvent B until precipitation of a material is visible in the solution, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, allowing the solution to cool down under stirring until formation of a supernatant and a residue, removing the supernatant or b) providing solvent B, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, heating solvent B at a temperature above 30° C.

Abstract: A method for preparing a phosphitylated compound comprising the step of:—reacting a hydroxyl containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R1, R2=either H or form a 5 to 6-membered ring together. X1, X2=independently either N or CH Y=H or Si(R4)3, with R4=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl B=deprotonated acid. The hydroxyl containing compound is preferably a sugar moiety or a nucleoside or an oligomer derived therefrom.

Abstract: A method for purifying a protected oligonucleotide comprising the steps of: a) providing a solution of the protected oligonucleotide in at least one solvent A having a boiling point below the boiling point of a solvent B, heating the solution at a temperature of at least 30° C. and below the boiling point of the at least solvent A, adding solvent B until precipitation of a material is visible in the solution, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, allowing the solution to cool down under stirring until formation of a supernatant and a residue, removing the supernatant or b) providing solvent B, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, heating solvent B at a temperature above 30° C.

Abstract: A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having the formula (A), b) reacting said compound with a phosphitylating agent in the presence of an activator (activator I) having the formula (I) to prepare a phosphitylated compound; and c) reacting said phosphitylated compound without isolation with a second compound having the formula (A) wherein R5, R3, R2, B are independently selected, but have the same definition as above in the presence of an activator II different from activator I.

Abstract: A method for preparing a phosphitylated compound comprising the step of:—reacting a hydroxyl containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R1, R2=either H or form a 5 to 6-membered ring together. X1, X2=independently either N or CH Y?H or Si(R4)3, with R4=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl B=deprotonated acid. The hydroxyl containing compound is preferably a sugar moiety or a nucleoside or an oligomer derived therefrom.

Abstract: A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large-scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3?-protected compound of formula: with a nucleotide derivative having a 5?-protection group, or reacting a 5?-protected compound of formula with a nucleotide derivative having a 3?-protection group.

Abstract: A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large- scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3?-protected compound of formula: with a nucleotide derivative having a 5?-protection group, or reacting a 5?-protected compound of formula with a nucleotide derivative having a 3?-protection group.

Abstract: A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having the formula (A), b) reacting said compound with a phosphitylating agent in the presence of an activator (activator I) having the formula (I) to prepare a phosphitylated compound; and c) reacting said phosphitylated compound without isolation with a second compound having the formula (A) wherein R5, R3, R2, B are independently selected, but have the same definition as above in the presence of an activator II different from activator I.

Abstract: A process for the synthesis of compounds of general formulas comprising the step of reacting in the presence of wherein: R=substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R1 and R2 independently represent H, substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R?=H, OH, OR or OSiX3, wherein X independently represent alkyl or aryl.

Abstract: A method for purifying a protected oligonucleotide comprising the steps of: a) providing a solution of the protected oligonucleotide in at least one solvent A having a boiling point below the boiling point of a solvent B, heating the solution at a temperature of at least 30° C. and below the boiling point of the at least solvent A, adding solvent B until precipitation of a material is visible in the solution, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, allowing the solution to cool down under stirring until formation of a supernatant and a residue, removing the supernatant or b) providing solvent B, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms, heating solvent B at a temperature above 30° C.

Abstract: A method for preparing a phosphitylated compound comprising the step of: -reacting hydroxyl containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R1, R2=either H or form a 5 to 6-membered ring together. X1, X2=independently either N or CH Y?H or Si(R4)3, with R4=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl B=deprotonated acid. The hydroxyl containing compound is preferably a sugar moiety or a nucleoside or an oligomer derived therefrom.

Abstract: A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large-scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3?-protected compound of formula: with a nucleotide derivative having a 5?-protection group, or reacting a 5?-protected compound of formula with a nucleotide derivative having a 3?-protection group.

Abstract: A process for the synthesis of compounds of general formulas comprising the step of reacting in the presence of wherein: R=substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R1 and R2 independently represent H, substituted or unsubstituted alkyl, aryl, heterocycles containing one or more O, N, S, P or B; R??H, OH, OR or OSiX3, wherein X independently represent alkyl or aryl.

Abstract: A method for preparing an oligonucleotide comprising the steps of a) providing a 3-protected compound having the formula: wherein B is a heterocyclic base R2 is H, a protected 2-hydroxyl group, F, a protected amino group, an O-alkyl group, an O-substituted alkyl, a substituted alkylamino or a C4?-O2?methylen linkage R3 is OR?3, NHR?3, NR?3R??3, a 3?-protected nucleotide or a 3?-protected oligonucleotide, R?3 is a hydroxyl protecting group, R?3, R??3 are independently an amine protecting group, b) reacting said compound with a nucleotide derivative having a 5-proctection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond c) optionally processing the elongated oligonucleotide with a P(III)-internucleotide bond by either or both of steps c1) and c2) in any sequence c1) capping preferably by reacting with a solid supported capping agent c2) oxidizing preferably by reacting the oligonucleotide with a solid supported oxidizing reagent d) remo

Abstract: Organic phosphorus compounds possessing 3-hydroxyalkylphosphinic acid ester groups of the formula ##STR1## wherein the individual symbols have the meaning given in the description. These compounds have been obtained by reaction of compounds containing one or more hydroxyl groups with a 2-substituted 2-oxo-oxa-phospholane. The products of the above formula are in particular suitable for use as flameproofing agents for textile material.

Abstract: Mixtures of oligomeric phosphorus compounds which are obtained in the first step by reaction of a mono- to hexavalent alcohol with phosphinic, phosphonic and phosphoric acid derivatives containing at least one anhydride oxygen and possibly containing terminal acid P-OH radicals and by subsequent reaction in the second step with alkylene oxides or alkylene carbonates. These phosphorus compounds which contain hydroxyalkylphosphonic acid groups, may be suitably employed directly as flame-retardant finishes for textile articles or as intermediates thereof.

Abstract: Organic phosphorus compounds with 2-hydroxyalkylphosphonic acid groups of the general formula I ##STR1## the individual symbols in the above formula I having the meaning as given in the description. The compounds, which are used as flame retardants for textile material, are prepared by reacting 1 mole of a compound of the general formula IIZ.sub.n (OH).sub.n (II)with 1 to n.

Abstract: Bisphosphinic acid anhydrides of the formula ##STR1## in which R is a saturated open chain or cyclic alkylene radical, an arylene or aralkylene radical, and R.sup.1 and R.sup.2, which may be identical or different, represent optionally halogen substituted alkyl, aryl or aralkyl radicals, and m represents an integer .gtoreq.1, preferably .gtoreq.2 and a process for their preparation which comprises reacting bisphosphinic acid derivatives of the formula ##STR2## in which R.sup.3 and R.sup.4, are hydrogen, monovalent cations, the ammonium group or optionally halogen-substituted alkyl groups, with inorganic acid chlorides and/or with phosgene and/or with oxalyl chloride and/or with the corresponding bromine compounds in a molar ratio of about 1:1 at a temperature up to 250.degree. C.

Abstract: Carbamoyl-oxyalkyl-phosphinic acid derivatives or mixtures thereof of the formula ##STR1## in which Z.sub.n is an n-valent, saturated C.sub.1 -C.sub.6 -hydrocarbon group, R.sub.1 is an optionally branched C.sub.1 -C.sub.6 -alkyl group, which group may be substituted by a halogen atom, or a phenyl group, R.sub.2 is an optionally branched C.sub.2 -C.sub.7 -alkylene group, a is zero to n-1 and n is an integer of from 1 to 4. These compounds can be prepared by reacting phosphonites of the formula II ##STR2## in the presence of radical-forming agents, with a carbamate of the formula IIICH.sub.2 .dbd.R.sub.3 --O--CO--NH.sub.2 IIIin which R.sub.3 is an optionally branched C.sub.2 -C.sub.7 -alkylene group and is identical with the radical R.sub.2 containing one hydrogen atom less. The compounds are used as flame-retardants for textiles.

Abstract: Compounds of the formula ##STR1## WHEREIN Z is alkyl with 2 to 6 carbom atoms, x is oxygen, NH or sulfur, n and m are integers from 2 to 6, r is zero or 1, R.sup.4, R.sup.5 R.sup.6 and R.sup.7 are hydrogen or methyl and R.sup.3 is methyl, ethyl or phenyl. They are obtained by reacting 1 mole of a compound of formulaZ--(X--H).sub.nwith n.multidot.m moles of an alkylencoxide or alkylenecarbonate of the formulas ##STR2## and n(m+r) moles of a phospholane of formula ##STR3## These compounds are used as flameproofing agents especially for pile carpets.