Patents by Inventor Fritz Topfmeier

Fritz Topfmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4845030
    Abstract: The present invention is concerned with the use of aniline derivatives of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a --(CH.sub.2).sub.n --X radical, in which n is a whole number of from 1 to 3, X is H, OH, NH.sub.2, CH.sub.3 CONH, CH.sub.3 SO.sub.2 NH, COOH, SO.sub.3 H or --ArSO.sub.3 H, Ar being an optionally substituted arylene radical, m is a whole number of from 2 to 4, R.sup.3 is a hydrogen atom, an alkyl radical containing up to 3 carbon atoms, OCH.sub.3, CH.sub.3 CONH, COOH or SO.sub.3 H and R.sup.4 is a hydrogen, chlorine or bromine atom or a carboxylic acid or sulphonic acid group, as coupling components in oxidative color formation reactions.The present invention also provides an agent for the analytical determination of oxidizing substances by oxidative color coupling which, as coupling component, contains at least one compound of general formula (I).
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: July 4, 1989
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Georg Batz, Rupert Herrmann, Fritz Topfmeier, Helmut Schlumberger
  • Patent number: 4822807
    Abstract: The present invention provides a process for the preparation of cystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169.degree. C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.The present invention also provides pharmaceutical compositions containing torasemide of modification I.
    Type: Grant
    Filed: October 20, 1987
    Date of Patent: April 18, 1989
    Assignee: Boehringer Mannheim GmbH
    Inventors: Fritz Topfmeier, Gustav Lettenbauer
  • Patent number: 4743693
    Abstract: The present invention provides a process for the preparation of crystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169.degree. C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.The present invention also provides a pharmaceutical compositions containing torasemide of modification I.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: May 10, 1988
    Assignee: Boehringer Mannheim GmbH
    Inventors: Fritz Topfmeier, Gustav Lettenbauer
  • Patent number: RE34580
    Abstract: The present invention provides a process for the preparation of crystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, .[.melting point 162.degree. C.).]. .Iadd.in prism form) .Iaddend.from torasemide of modification II (monoclinic, space group P2/n, .[.melting point 169.degree..),.]. .Iadd.in leaflet form), .Iaddend.wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.The present invention also provides a pharmaceutical compositions containing .Iadd.stable .Iaddend.torasemide of modification I.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: April 5, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventors: Fritz Topfmeier, Gustav Lettenbauer
  • Patent number: RE34672
    Abstract: The present invention provides a process for the preparation of cystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169.degree. C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.The present invention also provides pharmaceutical compositions containing torasemide of modification I.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: July 26, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventors: Fritz Topfmeier, Gustav Lettenbauer