Abstract: The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths.

Abstract: Magnetic nanoparticles exhibiting enhanced heating ability in thermotherapeutic applications are described, as are several strategies to conjugate such nanoparticles. Methods for using conjugated nanoparticles are also provided.

Abstract: The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths.

Abstract: Disclosed are biocompatible magnetic nanoparticle compositions for various therapeutic or biological applications, and methods related thereto. Specifically, the present invention pertains to magnetic nanoparticle compositions prepared via high-pressure homogenization processes that include a turbulent flow zone. The methods of production may involve a two-step or a one-step process. The disclosed magnetic nanoparticle compositions may be useful in the treatment of the body, body part, tissue, cell, or body fluid of a subject for a variety of indications. The disclosed magnetic nanoparticle compositions may also be useful in the fixation, separation, transportation, marking or coding of targets, or energy transformation processes.