Patents by Inventor Frode Rise

Frode Rise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of free radicals in ESR and ESREMR imaging
    Patent number: 5827501
    Abstract: The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 27, 1998
    Assignee: Nycomed Imaging AS
    Inventors: Mikkel J.o slashed.rgensen, Frode Rise, Sven Andersson, Torsten Almen, Arne Aabye, Lars-Goran Wistrand, H.ang.kan Wikstrom, Klaes Golman, Rolf Servin, Peter Michelsen
  • Steroidal ester contrast media for x-ray and magnetic resonance imaging
    Patent number: 5725840
    Abstract: The present invention relates to metabolically labile esters, and to contrast media for X-ray and magnetic resonance imaging comprising these esters. The esters have formula (I): ##STR1## in which R.sup.3 is asteroid residue. The esters contain at least one iodine atom and/or heavy metal atom. The compound are metabolizable to products which are soluble in body fluids and are physiologically acceptable.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: March 10, 1998
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Frode Rise, John Varadarajan, Arne J.o slashed.rgen Aasen
  • Use of persistent free-radicals in magnetic resonance imaging
    Patent number: 5700448
    Abstract: The present invention relates to the use of persistent free radicals, in particular persistent free radicals having a carbon-based .pi.-bonded electronic system available for delocalization of the unpaired electrons as image enhancing agents in magnetic resonance imaging (MRI), in particular electron spin resonance enhanced magnetic resonance imaging (ESREMRI). The invention also relates to contrast media containing such radicals and to the use of such radicals and their non-radical precursors in the manufacture of MRI and ESREMRI contrast media.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: December 23, 1997
    Assignee: Nycomed Imaging AS
    Inventors: Klaes Golman, Sven Andersson, Frode Rise, Lars-Goran Wistrand, Hakan Wikstrom
  • Triarylmethyl radicals and the use of inert carbon free radicals in MRI
    Patent number: 5599522
    Abstract: A radical compound of formula Ia.C(Ar.sup.12).sub.3 (Ia)wherein:each Ar.sup.12, which may be the same or different, represents a 6-membered carbocyclic, at least one group Ar.sup.12 being a group Ar.sup.1 ;each group Ar.sup.1 represents a 6-membered ring optionally substituted at the or any ortho carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4, at the or any meta carbon by a group R.sup.2 or R.sup.3, and at any para carbon by a group R.sup.1, R.sup.2, R.sup.3 or R.sup.4,with the proviso that no more than two ring carbons are unsubstituted;each of R.sup.1, R.sup.2, R.sup.3 or R.sup.4, which may be the same or different, independently represents a group of formula --M, --XM, --XAr.sup.2 or --Ar.sup.2 ;M represents a water solubilizing group, each group X, which may be the same or different, represents an oxygen or sulphur atom or a NH or CH.sub.2 group.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: February 4, 1997
    Assignee: Nycomed Imaging AS
    Inventors: Mikkel J.o slashed.rgensen, Frode Rise, Sven Andersson, Torsten Almen, Klaes Golman
  • Use of persistent heterocyclic free-radicals in magnetic resonance imaging
    Patent number: 5435991
    Abstract: The present invention provides the use of a persistent .pi.-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising .pi.-system of said radical comprises at least one homo or heterocyclic ring, said radical being other than the chloranil semiquinone anion radical or a trityl radical. Also provided are magnetic resonance imaging contrast media containing and methods using such radicals.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: July 25, 1995
    Assignee: Nycomed Innovation AB
    Inventors: Klaes Golman, Sven Andersson, Frode Rise, Lars-Goran Wistrand, Hakan Wikstrom