Abstract: This disclosure provides systems, methods, and devices for image signal processing that support eye detection based image frame blending. In a first aspect, a method of image processing includes receiving a plurality of image frames and determining locations for one or more eyes depicted within the image frames. A first image frame may be selected from among the plurality of frames based on the locations of the one or more eyes. And output image frame may be determined by blending at least a subset of the plurality of image frames with the first image frame. In particular implementations, the first image frame may be used as an anchor frame for a multi-frame noise reduction (MFNR) process. Other aspects and features are also claimed and described.