Patents by Inventor Fuad Fares

Fuad Fares has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 12029780
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: July 9, 2024
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 11197915
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: December 14, 2021
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Treatment of cancer
    Patent number: 10758581
    Abstract: Methods of treating colorectal cancer using water extracts derived from dittrichia viscosa leaves are provided.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: September 1, 2020
    Assignee: CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
    Inventors: Fuad Fares, Rinat Bar Shalom, Shlomo Grossman, Margalit Bergman
  • Methods of treatment with long-acting growth hormone
    Patent number: 10351615
    Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: July 16, 2019
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 10221228
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 5, 2019
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing same
    Patent number: 10030060
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: July 24, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9975938
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 22, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9908924
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing same
    Patent number: 9896494
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: February 20, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9884901
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • TREATMENT OF CANCER
    Publication number: 20160106792
    Abstract: Methods of treating colorectal cancer using water extracts derived from dittrichia viscosa leaves are provided.
    Type: Application
    Filed: June 10, 2014
    Publication date: April 21, 2016
    Applicant: Carmel Haifa University Economic Corporation Ltd.
    Inventors: Fuad Fares, Rinat Bar Shalom, Shlomo Grossman, Margalit Bergman
  • Long-acting polypeptides and methods of producing same
    Patent number: 8999670
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: April 7, 2015
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 8946155
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 3, 2015
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • LONG-ACTING GROWTH HORMONE AND METHODS OF PRODUCING SAME
    Publication number: 20140371144
    Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: August 2, 2012
    Publication date: December 18, 2014
    Inventors: Fuad Fares, Udi Eyal Fima
  • Extracts of mushrooms, pharmaceutical compositions comprising them and a new strain
    Patent number: 8871197
    Abstract: A new and distinct variety of higher Basidiomycetes mushroom Cyathus striatus HAI-1302, and extracts thereof are provided. These extracts as well as pharmaceutical composition comprising them are capable of inhibiting growth of cancer cells, arresting cancer cell cycle, reducing DNA synthesis in cancer cells and inducing apoptosis in cancer cells, and are thus useful for the treatment of cancer.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: October 28, 2014
    Assignee: Carmel-Haifa University Economic Corporation Ltd.
    Inventors: Fuad Fares, Lital Shavit, Solomon P. Wasser
  • Long-acting veterinary polypeptides and methods of producing and administering same
    Patent number: 8465948
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: June 18, 2013
    Assignee: Prolor Biotech Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • EXTRACTS OF CYATHUS STRIATUS MUSHROOMS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND A NEW CYATHUS STRIATUS STRAIN
    Publication number: 20130142820
    Abstract: A new and distinct variety of higher Basidiomycetes mushroom Cyathus striatus HAI-1302, and extracts thereof are provided. These extracts as well as pharmaceutical composition comprising them are capable of inhibiting growth of cancer cells, arresting cancer cell cycle, reducing DNA synthesis in cancer cells and inducing apoptosis in cancer cells, and are thus useful for the treatment of cancer.
    Type: Application
    Filed: June 2, 2011
    Publication date: June 6, 2013
    Applicant: CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD
    Inventors: Fuad Fares, Lital Sharvit, Solomon P. Wasser
  • Long-acting growth hormone and methods of producing same
    Patent number: 8450269
    Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing growth or weight gain, method of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: May 28, 2013
    Assignee: Prolor Biotech Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing same
    Patent number: 8426166
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: April 23, 2013
    Assignee: Prolor Biotech Inc.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting interferons and derivatives thereof and methods thereof
    Patent number: 8323636
    Abstract: A polypeptide and polynucleotides encoding same comprising carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an IFN protein are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: December 4, 2012
    Assignee: Prolor Biotech Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima