Patents by Inventor Fuad Fares

Fuad Fares has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND METHOD FOR TREATING CANCER
    Publication number: 20230226013
    Abstract: A fractionation method, pure active compounds and derivatives thereof, compositions including the same and methods of treating cancer including administering such compounds, derivatives, compositions or any combination thereof. A fractionation method of a Cyathus striatus CBS 126585 for obtaining at least one of the pure active ingredients Striatal C, Striatal C? or Striatal D, wherein the fractionation method includes: providing an octadecyl silica gel column; and performing a series of RP-18 preparative chromatography steps using the acetadecyl silica gel column.
    Type: Application
    Filed: December 3, 2020
    Publication date: July 20, 2023
    Inventors: Fuad FARES, Lital SHARVIT, Solomon WASSER
  • HUMAN HEAD AND NECK CANCER TREATMENT
    Publication number: 20220296629
    Abstract: The present invention is directed to an expression vector and a composition comprising same, wherein the expression includes a precursor of miR-193 a. Further provided are methods of using the expression vector of the invention or the composition comprising same, such as in diagnosing and/or treating head and neck squamous cell carcinoma, in a subject in need thereof.
    Type: Application
    Filed: June 3, 2020
    Publication date: September 22, 2022
    Inventors: Fuad FARES, Reem MIARI
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20220241380
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Application
    Filed: December 13, 2021
    Publication date: August 4, 2022
    Applicant: OPKO BIOLOGICS LTD.
    Inventors: Fuad FARES, Udi Eyal FIMA
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 11197915
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: December 14, 2021
    Assignee: OPKO BIOLOGICS LTD.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Treatment of cancer
    Patent number: 10758581
    Abstract: Methods of treating colorectal cancer using water extracts derived from dittrichia viscosa leaves are provided.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: September 1, 2020
    Assignee: CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
    Inventors: Fuad Fares, Rinat Bar Shalom, Shlomo Grossman, Margalit Bergman
  • METHODS OF TREATMENT WITH LONG-ACTING HORMONE
    Publication number: 20200131242
    Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: July 15, 2019
    Publication date: April 30, 2020
    Applicant: OPKO BIOLOGICS LTD.
    Inventors: Fuad FARES, Udi Eyal FIMA
  • Methods of treatment with long-acting growth hormone
    Patent number: 10351615
    Abstract: Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: July 16, 2019
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 10221228
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 5, 2019
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20180251510
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Application
    Filed: November 26, 2014
    Publication date: September 6, 2018
    Applicant: OPKO Biologics Ltd.
    Inventors: Fuad FARES, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing same
    Patent number: 10030060
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: July 24, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20180186852
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: February 16, 2018
    Publication date: July 5, 2018
    Applicant: Opko Biologics Ltd.
    Inventors: Fuad FARES, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9975938
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: May 22, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9908924
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also discarded.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing same
    Patent number: 9896494
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: February 20, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • Long-acting polypeptides and methods of producing and administering same
    Patent number: 9884901
    Abstract: A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 6, 2018
    Assignee: OPKO Biologics Ltd.
    Inventors: Fuad Fares, Udi Eyal Fima
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20160310576
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 27, 2016
    Applicant: OPKO Biologics Ltd.
    Inventors: Fuad FARES, Udi Eyal Fima
  • TREATMENT OF CANCER
    Publication number: 20160106792
    Abstract: Methods of treating colorectal cancer using water extracts derived from dittrichia viscosa leaves are provided.
    Type: Application
    Filed: June 10, 2014
    Publication date: April 21, 2016
    Applicant: Carmel Haifa University Economic Corporation Ltd.
    Inventors: Fuad Fares, Rinat Bar Shalom, Shlomo Grossman, Margalit Bergman
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20150203558
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: December 10, 2014
    Publication date: July 23, 2015
    Inventors: FUAD FARES, UDI EYAL FIMA
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
    Publication number: 20150158926
    Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 11, 2015
    Inventors: FUAD FARES, UDI EYAL FIMA
  • LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
    Publication number: 20150152155
    Abstract: A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
    Type: Application
    Filed: November 21, 2014
    Publication date: June 4, 2015
    Inventors: Fuad FARES, Udi Eyal Fima