Abstract: Herein is provided a recombinant tumor-selective viral particle comprising a nucleic acid encoding a recombinant polypeptide for directing an extracellular vesicle (EV) to at least one target cell, said recombinant polypeptide comprising: at least one targeting moiety for directing said EV to said at least one target molecule expressed by said at least one target cell; at least one EV-anchoring polypeptide; and at least one intravesicular polypeptide. The viral particle may be from an oncolytic viruses. Recombinant polypeptides for programming EVs to target particular molecules are also provided. Also described are therapeutic EVs for delivering payload polypeptides (and/or cargo molecules) to target cells, e.g., in vaccine or cell-free “CAR-T”-like applications, along with EVs for recruiting immune cells to target cells in EV-mediated BiTE -like applications. Oncolytic viruses may also be engineered to infect tumor cells and shed programmed EVs, yielding additional therapeutic effects.

Abstract: Provided is a water baffling structure, for keeping out condensate water generated on a small elbow (31) of an evaporator (30). The water baffling structure includes a water baffle body (10), the water baffle body (10) is mounted on a motor seat (20), and at least part of the water baffle body (10) covers the small elbow (31). An air conditioner with the water baffling structure is further provided.

Abstract: The invention provides compositions comprising rolling circle amplification sequences and hairpin sequences specifically designed for the accurate and highly sensitive detection of one or more analyte sequences. The invention further provides kits comprising them and methods for their use.

Abstract: The invention provides compositions comprising rolling circle amplification sequences and hairpin sequences specifically designed for the accurate and highly sensitive detection of one or more analyte sequences. The invention further provides kits comprising them and methods for their use.