Abstract: The invention discloses an operating method and system for a PCB drilling-milling machine using different motion control products. The method comprises that a PCB drilling-milling machine runs a control module of a motion control product by running a drilling-milling module. The operating method further comprises: storing a control module of at least one motion control product in the PCB drilling-milling machine; inputting a selection information which is a code of a desired motion control product while running the drilling-milling module; and, the PCB drilling-milling machine matching the selection information with the code(s) of all the motion control product(s) stored during the step 1, and running the control module of the motion control product matched with the selection information. The invention makes the drilling-milling machine compatible with different motion control products via one drilling-milling module.