Patents by Inventor Fujio Antoku
Fujio Antoku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7396842Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.Type: GrantFiled: April 22, 2005Date of Patent: July 8, 2008Assignee: Dianippon Sumitomo Pharma Co., Ltd.Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
-
Publication number: 20050222226Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.Type: ApplicationFiled: April 22, 2005Publication date: October 6, 2005Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
-
Patent number: 6951866Abstract: 1. A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.Type: GrantFiled: August 19, 2002Date of Patent: October 4, 2005Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
-
Patent number: 6919361Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.Type: GrantFiled: June 28, 2001Date of Patent: July 19, 2005Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
-
Publication number: 20040072827Abstract: A 5-membered cyclic compound of the formula: 1Type: ApplicationFiled: December 30, 2002Publication date: April 15, 2004Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
-
Publication number: 20030105323Abstract: 1.Type: ApplicationFiled: August 19, 2002Publication date: June 5, 2003Applicant: SUMITOMO PHARMACEUTICALS COMPANY LIMITEDInventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
-
Patent number: 6458798Abstract: A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.Type: GrantFiled: February 27, 2001Date of Patent: October 1, 2002Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
-
Patent number: 4948799Abstract: An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.Type: GrantFiled: January 4, 1989Date of Patent: August 14, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Atsuyuki Kojima, Kukuo Ishizumi
-
Patent number: 4937249Abstract: A compound of the formula: ##STR1## or its acid addition salt, which is useful as a psychotic drug.Type: GrantFiled: October 25, 1988Date of Patent: June 26, 1990Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Kikuo Ishizumi
-
Patent number: 4843078Abstract: A succinimide derivative of the formula: ##STR1## wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.Type: GrantFiled: April 15, 1988Date of Patent: June 27, 1989Assignee: Sumitono Pharmaceutical Company, LimitedInventors: Kikuo Ishizumi, Fujio Antoku, Isamu Maruyama, Atsuyuki Kojima
-
Patent number: 4812461Abstract: An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.Type: GrantFiled: September 25, 1987Date of Patent: March 14, 1989Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Atsuyuki Kojima, Kukuo Ishizumi
-
Patent number: 4745117Abstract: A compound of the formula: ##STR1## wherein A is a carbonyl group or a sulfonyl group;B is either one of the formulas: ##STR2## (in which E is a methylene group, an ethylene group or an oxygen atom and a full line accompanying a broken line ( ) indicates a single bond or a double bond), ##STR3## (in which F is a methylene group or an ethylene group and a full line accompanying a broken line ( ) is as defined above) and ##STR4## (in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each a hydrogen atom or a methyl group) when A represents a carbonyl group, or B is a 1,2-phenylene group when A represents a sulfonyl group;D is an ethylene group, an ethenylene group or an ethynylene group, of which one or more may be optionally substituted with hydroxyl; andn is an integer of 0, 1 or 2, or its acid addition salt. These compounds are useful for the treatment or psychosis.Type: GrantFiled: March 27, 1986Date of Patent: May 17, 1988Assignee: Sumitomo Pharmaceuticals Company, LimitedInventors: Kikuo Ishizumi, Fujio Antoku, Isamu Maruyama, Atuyuki Kojima
-
Patent number: 4598078Abstract: A succinimide derivative of the formula: ##STR1## wherein A is straight or branched C.sub.2 -C.sub.6 alkylene or alkenylene, B is straight or branched C.sub.3 -C.sub.5 alkylene, D is straight or branched C.sub.2 -C.sub.3 alkylene, E is straight or branched C.sub.2 -C.sub.3 alkylene, R.sup.1 and R.sup.2 are each hydrogen or C.sub.1 -C.sub.4 alkyl, or they may form a single bond and R.sup.3 is a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: ##STR2## (in which R.sup.4 is hydrogen or phenyl), a group of the formula: CO--R.sup.5 (in which R.sup.5 is adamantyl or furyl) or hydroxy (C.sub.2 -C.sub.4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.Type: GrantFiled: October 19, 1983Date of Patent: July 1, 1986Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami
-
Patent number: 4543355Abstract: Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.Type: GrantFiled: January 8, 1985Date of Patent: September 24, 1985Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami
-
Patent number: 4507303Abstract: Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line ( ) is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.Type: GrantFiled: December 1, 1982Date of Patent: March 26, 1985Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami