Patents by Inventor Fujio Antoku

Fujio Antoku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7396842
    Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: July 8, 2008
    Assignee: Dianippon Sumitomo Pharma Co., Ltd.
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Publication number: 20050222226
    Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
    Type: Application
    Filed: April 22, 2005
    Publication date: October 6, 2005
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Patent number: 6951866
    Abstract: 1. A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: October 4, 2005
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
  • Patent number: 6919361
    Abstract: A 5-membered cyclic compound of the formula: wherein X is oxygen or sulfur, R1 is hydrogen, substituted or unsubstituted alkyl, etc., R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, etc., Y1 is a direct bond, substituted or unsubstituted alkylene, —CO(CH2)n—, etc., the wavy line means (E)-configuration or (Z)-configuration, R3 is substituted or unsubstituted aryl, etc., Y2 is substituted or unsubstituted alkylene, etc., R4 is hydrogen, substituted or unsubstituted alkanoyl, substituted or unsubstituted alkyl, etc., R5 is hydrogen, etc., or a salt thereof, these compound being able to inhibit infiltration of leukocytes such as eosinophils and lymphocytes, by which being useful for the treatment of various kinds of inflammation.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: July 19, 2005
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Publication number: 20040072827
    Abstract: A 5-membered cyclic compound of the formula: 1
    Type: Application
    Filed: December 30, 2002
    Publication date: April 15, 2004
    Inventors: Norio Fujiwara, Hitoshi Fujita, Fujio Antoku, Toshinari Sugasawa, Hajime Kawakami
  • Publication number: 20030105323
    Abstract: 1.
    Type: Application
    Filed: August 19, 2002
    Publication date: June 5, 2003
    Applicant: SUMITOMO PHARMACEUTICALS COMPANY LIMITED
    Inventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
  • Patent number: 6458798
    Abstract: A pyrimidine derivative of the formula (1) or a salt thereof; has an inhibitory activity of production of Th2 type cytokines such as IL-4, IL-5, etc., and is useful as an therapeutic agent for allergic diseases, autoimmune diseases such as systemic lupus erythemathosus, etc., and acquired immunodeficiecy syndrome (AIDS) and so on.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: October 1, 2002
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Hitoshi Fujita, Fujio Antoku, Norio Fujiwara, Kiyotaka Iwai, Hiroshi Tanaka, Hajime Kawakami
  • Patent number: 4948799
    Abstract: An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.
    Type: Grant
    Filed: January 4, 1989
    Date of Patent: August 14, 1990
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Atsuyuki Kojima, Kukuo Ishizumi
  • Patent number: 4937249
    Abstract: A compound of the formula: ##STR1## or its acid addition salt, which is useful as a psychotic drug.
    Type: Grant
    Filed: October 25, 1988
    Date of Patent: June 26, 1990
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Kikuo Ishizumi
  • Patent number: 4843078
    Abstract: A succinimide derivative of the formula: ##STR1## wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.
    Type: Grant
    Filed: April 15, 1988
    Date of Patent: June 27, 1989
    Assignee: Sumitono Pharmaceutical Company, Limited
    Inventors: Kikuo Ishizumi, Fujio Antoku, Isamu Maruyama, Atsuyuki Kojima
  • Patent number: 4812461
    Abstract: An imide derivative of the formula: ##STR1## or a pharmaceutically acceptable salt, which is useful as an antipsychotic drug.
    Type: Grant
    Filed: September 25, 1987
    Date of Patent: March 14, 1989
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Fujio Antoku, Mayumi Yoshigi, Ikutaro Saji, Atsuyuki Kojima, Kukuo Ishizumi
  • Patent number: 4745117
    Abstract: A compound of the formula: ##STR1## wherein A is a carbonyl group or a sulfonyl group;B is either one of the formulas: ##STR2## (in which E is a methylene group, an ethylene group or an oxygen atom and a full line accompanying a broken line ( ) indicates a single bond or a double bond), ##STR3## (in which F is a methylene group or an ethylene group and a full line accompanying a broken line ( ) is as defined above) and ##STR4## (in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each a hydrogen atom or a methyl group) when A represents a carbonyl group, or B is a 1,2-phenylene group when A represents a sulfonyl group;D is an ethylene group, an ethenylene group or an ethynylene group, of which one or more may be optionally substituted with hydroxyl; andn is an integer of 0, 1 or 2, or its acid addition salt. These compounds are useful for the treatment or psychosis.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: May 17, 1988
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Kikuo Ishizumi, Fujio Antoku, Isamu Maruyama, Atuyuki Kojima
  • Patent number: 4598078
    Abstract: A succinimide derivative of the formula: ##STR1## wherein A is straight or branched C.sub.2 -C.sub.6 alkylene or alkenylene, B is straight or branched C.sub.3 -C.sub.5 alkylene, D is straight or branched C.sub.2 -C.sub.3 alkylene, E is straight or branched C.sub.2 -C.sub.3 alkylene, R.sup.1 and R.sup.2 are each hydrogen or C.sub.1 -C.sub.4 alkyl, or they may form a single bond and R.sup.3 is a phenyl group optionally substituted with C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen and/or trifluoromethyl, a 2-pyridyl group optionally substituted with halogen, a 2-pyrimidyl group optionally substituted with halogen, a group of the formula: ##STR2## (in which R.sup.4 is hydrogen or phenyl), a group of the formula: CO--R.sup.5 (in which R.sup.5 is adamantyl or furyl) or hydroxy (C.sub.2 -C.sub.4) alkyl, and an acid addition salt thereof, which are useful as anti-anxiety drugs and/or anti-allergic drugs.
    Type: Grant
    Filed: October 19, 1983
    Date of Patent: July 1, 1986
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami
  • Patent number: 4543355
    Abstract: Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.
    Type: Grant
    Filed: January 8, 1985
    Date of Patent: September 24, 1985
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami
  • Patent number: 4507303
    Abstract: Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line ( ) is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: ##STR3## (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.
    Type: Grant
    Filed: December 1, 1982
    Date of Patent: March 26, 1985
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kikuo Ishizumi, Fujio Antoku, Yukio Asami