Patents by Inventor Fujio Tabusa
Fujio Tabusa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8551999Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.Type: GrantFiled: October 29, 2008Date of Patent: October 8, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takumi Sumida, Fujio Tabusa, Kazuo Sekiguchi, Takeshi Kodama, Koichi Yasumura, Yutaka Kojima, Masaaki Motoyama, Keisuke Miyajima, Kenji Yoshida, Keizo Kan, Makoto Sakamoto, Hideki Takasu, Takashi Nakagawa, Naoto Ohi, Yasuo Harada, Norikazu Hashimoto, Hironori Matsuyama, Masatoshi Iida, Shigekazu Fujita, Tae Fukushima
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Patent number: 8354439Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.Type: GrantFiled: December 12, 2006Date of Patent: January 15, 2013Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masatoshi Chihiro, Takayuki Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Kurimura, Fujio Tabusa
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Publication number: 20100261720Abstract: The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.Type: ApplicationFiled: October 29, 2008Publication date: October 14, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Takumi Sumida, Fujio Tabusa, Kazuo Sekiguchi, Takeshi Kodama, Koichi Yasumura, Yutaka Kojima, Masaaki Motoyama, Keisuke Miyajima, Kenji Yoshida, Keizo Kan, Makoto Sakamoto, Hideki Takasu, Takashi Nakagawa, Naoto Ohi, Yasuo Harada, Norikazu Hashimoto, Hironori Matsuyama, Masatoshi Iida, Shigekazu Fujita, Tae Fukushima
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Publication number: 20070238758Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.Type: ApplicationFiled: May 16, 2007Publication date: October 11, 2007Inventors: Masatoshi Chihiro, Takayuki Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Kurimura, Fujio Tabusa
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Publication number: 20070105911Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: (wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.Type: ApplicationFiled: December 12, 2006Publication date: May 10, 2007Inventors: Masatoshi Chihiro, Takayuki Matsuzani, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Jurimura, Fujio Tabusa
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Publication number: 20040014792Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: 1Type: ApplicationFiled: April 29, 2003Publication date: January 22, 2004Applicant: Otsuka Pharmaceutical Co. Ltd.Inventors: Masatoshi Chihiro, TakayukI Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Fujio Tabusa
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Patent number: 6583163Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.Type: GrantFiled: June 25, 2001Date of Patent: June 24, 2003Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masatoshi Chihiro, Takayuki Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Kurimura, Fujio Tabusa
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Publication number: 20020013469Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: 1Type: ApplicationFiled: June 25, 2001Publication date: January 31, 2002Applicant: Otsuka Pharmaceutical Co., Ltd.Inventors: Masatoshi Chihiro, Takayuki Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Kurimura, Fujio Tabusa
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Patent number: 6291487Abstract: The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: [wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.Type: GrantFiled: March 29, 1999Date of Patent: September 18, 2001Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masatoshi Chihiro, Takayuki Matsuzaki, Hisashi Nagamoto, Goro Miyakoda, Shinobu Sueyoshi, Toyoki Mori, Kazuyoshi Kitano, Isao Takemura, Hiroshi Yamashita, Muneaki Kurimura, Fujio Tabusa
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Patent number: 6140330Abstract: A thiazole compound of the formula: ##STR1## wherein T is lower alkylene; u is 0 or 1; R.sup.1 and R.sup.2 are the same or different and are each H, or lower alkyl, etc.; R.sup.3 is ##STR2## R.sup.4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity on protein kinase C (PKC, Ca.sup.2+ /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.Type: GrantFiled: March 24, 1998Date of Patent: October 31, 2000Assignee: Otsuka Pharmaceutical Company, LimitedInventors: Toyoki Mori, Michiaki Tominaga, Fujio Tabusa, Kazuyoshi Nagami, Kaoru Abe, Kenji Nakaya, Isao Takemura, Tomoichi Shinohara, Yoshihisa Tanada, Takahito Yamauchi
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Patent number: 6136826Abstract: The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity.Said piperidine derivative or pharmaceutically acceptable salt thereof is represented by the general formula (1): ##STR1## (wherein R, R.sup.1 and R.sup.2 are the same as defined above.Type: GrantFiled: April 28, 1998Date of Patent: October 24, 2000Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Fujioka, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Fujio Tabusa, Michiaki Tominaga
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Patent number: 5760058Abstract: Peripheral vasodilating agents containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity, said piperidine derivative or pharmaceutically acceptable salt thereof being represented by the general formula (1) ##STR1## wherein R, R.sup.1 and R.sup.2 are as defined herein.Type: GrantFiled: February 3, 1997Date of Patent: June 2, 1998Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Fujioka, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Fujio Tabusa, Michiaki Tominaga
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Patent number: 5656642Abstract: The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity.Said piperidine derivative or pharmaceutically acceptable salt thereof is represented by the general formula (1): ##STR1## (wherein R, R.sup.1 and R.sup.2 are the same as defined above.Type: GrantFiled: December 6, 1994Date of Patent: August 12, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Fujioka, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Fujio Tabusa, Michiaki Tominaga
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Patent number: 5591751Abstract: Peripheral vasodilating agents containing, as the active ingredient, carbostyril derivatives represented by the general formula: ##STR1## or a salt thereof; and novel carbostyril derivatives included within the scope of the above-mentioned general formula.Type: GrantFiled: October 14, 1994Date of Patent: January 7, 1997Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Takafumi Fujioka, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Fujio Tabusa, Michiaki Tominaga
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Patent number: 5358949Abstract: Carbostyril derivatives or salt thereof, including novel compounds, having activities for curing and/or improving arrhythmia.Some carbostyril derivatives having similar chemical structural formula to those of carbostyril derivatives of the present invention are known in the prior art references, however, above-mentioned pharmacological activities have not been known yet.Type: GrantFiled: March 6, 1991Date of Patent: October 25, 1994Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Fujio Tabusa, Kazuyoshi Nagami, Hironori Tsutsui
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Patent number: 4416884Abstract: A piperazinylbenzoheterocyclic compound having antimicrobial properties and represented by the formula (I) ##STR1## wherein R.sup.1 represents hydrogen or lower alkyl; R.sup.2 represents hydrogen; R.sup.3 represents hydrogen, lower alkyl, lower alkanoyl, lower alkylsulfonyl, phenylalkyl, benzoyl, p-toluenesulfonyl, a group represented by the formula ##STR2## lower alkyl substituted with one to three of halogen and hydroxy, lower alkanoyl substituted with one to seven of halogen, phenylalkyl substituted with one to three of lower alkoxy on the phenyl ring, lower alkylsulfonyl substituted with one to three of halogen, lower alkenyl or lower alkynyl; R.sup.4 represents hydrogen or halogen, and n is an integer of 0 or 1, except that when n is 0, R.sup.1 and R.sup.2 together can represent the atoms necessary to form a cyclohexane ring, and when R.sup.Type: GrantFiled: October 9, 1980Date of Patent: November 22, 1983Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hiroshi Ishikawa, Fujio Tabusa, Kazuyuki Nakagawa
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Patent number: 4317820Abstract: A .beta.-lactam series compound represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a hydrogen atom; R.sup.3 represents a halogen atom, a nitro group, an amino group, a hydroxy group, a lower alkyl group, a lower alkoxy group, a lower alkanoylamino group, a lower alkanesulfonyloxy group or a group represented by the formula ##STR2## where R.sup.5 represents a hydrogen atom, a lower alkanoyl group, or a lower alkanesulfonyl group; R.sup.4 represents a hydrogen atom or a hydroxy group; n is 0 or 1; l is 0, 1 or 2; and A represents --C(CH.sub.3).sub.2 --CH(COOH)-- or --CH.sub.2 C(CH.sub.2 R.sup.6).dbd.C(COOH)-- where R.sup.6 represents a lower alkanoyloxy group, a group represented by the formula ##STR3## where R.sup.7 and R.sup.8 each represents a lower alkyl group and when n is 0, R.sup.1 and R.sup.Type: GrantFiled: April 10, 1979Date of Patent: March 2, 1982Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Hiroshi Ishikawa, Fujio Tabusa, Kazuyuki Nakagawa