Patents by Inventor Fukue Nagata
Fukue Nagata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220119498Abstract: To provide an immunoglobulin purification method which achieves a high immunoglobulin recovery percentage without causing loss of the antibody nature of an immunoglobulin. The immunoglobulin purification method includes an adsorption step and a desorption step. The adsorption step involves adsorption of an immunoglobulin onto porous zirconia particles in a neutral buffer. The desorption step involves desorption of the immunoglobulin adsorbed on the porous zirconia particles from the porous zirconia particles by means of a neutral desorption liquid.Type: ApplicationFiled: January 17, 2020Publication date: April 21, 2022Applicants: NGK Spark Plug Co., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Katsuya KATO, Fukue NAGATA, Shinjiro KASAHARA, Yuki HIROBE, Jun OTSUKA
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Publication number: 20220089453Abstract: Porous zirconia particles exhibit high specificity to a protein to be immobilized thereto and are used in immobilization of the protein. The porous zirconia particles have a pore diameter D50, at which a ratio of a cumulative pore volume to a total pore volume is 50%, the pore diameter D50 being in a range of 3.20 nm or more and 6.50 nm or less; and a pore diameter D90, at which a ratio of a cumulative pore volume to a total pore volume is 90%, the pore diameter D90 being in a range of 10.50 nm or more and 100.00 nm or less. The total pore volume of the particles is greater than 0.10 cm3/g. D50, D90, and the total pore volume are determined based on a pore diameter distribution measured through a BET method.Type: ApplicationFiled: January 17, 2020Publication date: March 24, 2022Applicants: NGK Spark Plug Co., LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Katsuya KATO, Fukue NAGATA, Shinjiro KASAHARA, Jun OTSUKA, Yuki HIROBE
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Patent number: 10751289Abstract: Provided are core-shell particles which are kept stable in a solvent such as water for a long period. Each core-shell particle includes a core which contains a hydrophobic polymer having an anionic group and a shell which contains calcium phosphate. At least one of calcium atoms contained in calcium phosphate is chemically bonded to a functional group derived from the anionic group. In a method of manufacturing core-shell particles each core-shell particle includes a core which contains a hydrophobic polymer and a shell which contains calcium phosphate, the method includes the steps of: mixing a water-soluble organic solution which contains a hydrophobic polymer having an anionic group with a solution which contains calcium ion so as to obtain a first mixed solution; mixing the first mixed solution with a solution which contains phosphate ions so as to obtain a second mixed solution; and stirring the second mixed solution.Type: GrantFiled: August 31, 2015Date of Patent: August 25, 2020Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Fukue Nagata, Katsuya Kato, Masahiko Inagaki
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Publication number: 20200216629Abstract: Provided is a composite body where ceramic crystals are thinly and uniformly coated onto a base material containing a hydrophilic polymer. The composite body has a base material containing a hydrophilic polymer, and a ceramic layer which is coated onto at least a portion of a surface of the base material, and the ceramic layer contains crystals having a laminated structure. The ceramic layer may contain calcium phosphate. A thickness of the ceramic layer is 0.3 nm to 50 nm. The composite body is produced through a step of mixing and stirring a dispersion liquid in which the base material is dispersed, a first solution containing calcium ions, and a second solution containing phosphate ions.Type: ApplicationFiled: January 29, 2018Publication date: July 9, 2020Inventors: Fukue NAGATA, Tatsuya MIYAJIMA, Katsuya KATO
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Publication number: 20170296479Abstract: Provided are core-shell particles which are kept stable in a solvent such as water for a long period. Each core-shell particle includes a core which contains a hydrophobic polymer having an anionic group and a shell which contains calcium phosphate. At least one of calcium atoms contained in calcium phosphate is chemically bonded to a functional group derived from the anionic group. In a method of manufacturing core-shell particles each core-shell particle includes a core which contains a hydrophobic polymer and a shell which contains calcium phosphate, the method includes the steps of: mixing a water-soluble organic solution which contains a hydrophobic polymer having an anionic group with a solution which contains calcium ion so as to obtain a first mixed solution; mixing the first mixed solution with a solution which contains phosphate ions so as to obtain a second mixed solution; and stirring the second mixed solution.Type: ApplicationFiled: August 31, 2015Publication date: October 19, 2017Inventors: Fukue NAGATA, Katsuya KATO, Masahiko INAGAKI
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Patent number: 6841143Abstract: This invention provides mesostructured oxide ceramics and a synthesizing method thereof, the synthesizing method employs a water-based solvent containing a metallic salt or metal complex as the ceramics precursor, template formed from an organic compound or the association thereof, and a precipitant, wherein mesostructured oxide ceramics are obtained from self-assembled oxide ceramics and organic substance by directly extracting oxide ceramics at a low temperature of 200° C. or less by utilizing a homogenous precipitation reaction from said ceramics precursor under the coexistence of a nanometer-sized template in the solvent, and separating and collecting the obtained precipitation, and mesostructured oxide ceramics is prepared by employing the synthesizing method described above.Type: GrantFiled: September 6, 2001Date of Patent: January 11, 2005Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masahiko Inagaki, Atsushi Hozumi, Kei Teraoka, Kaori Nishizawa, Fukue Nagata, Yoshiyuki Yokogawa, Tetsuya Kameyama
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Patent number: 6402517Abstract: The invention provides an artificial tooth root having acid resistance and anti-adherence of sordes and various germs, consisting of a substrate and a coating of calcium phosphate based ceramic having bioaffinity formed on the surface of this substrate, the substrate is composed of a polymer, ceramic, metal, or other material, the surface of the ceramic coating on the substrate surface is endowed with a protrusion-and-recession configuration, and is, chemically modified, and to a method for producing the artificial tooth root, by forming a coating of calcium phosphate based ceramic having bioaffinity over a substrate while imparting protrusions and recessions thereto, masking an area of the ceramic coating surface of which bioaffinity is required, and fixing a silane coupling agent exclusively over a predetermined area of the ceramic coating surface.Type: GrantFiled: February 25, 2000Date of Patent: June 11, 2002Assignee: Agency of Industrial Science and TechnologyInventors: Atsushi Hozumi, Masahiko Inagaki, Kaori Nishizawa, Fukue Nagata, Yoshiyuki Yokogawa, Tetsuya Kameyama
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Publication number: 20020031470Abstract: This invention provides mesostructured oxide ceramics and a synthesizing method thereof, the synthesizing method employs a water-based solvent containing a metallic salt or metal complex as the ceramics precursor, template formed from an organic compound or the association thereof, and a precipitant, wherein mesostructured oxide ceramics are obtained from self-assembled oxide ceramics and organic substance by directly extracting oxide ceramics at a low temperature of 200° C. or less by utilizing a homogenous precipitation reaction from said ceramics precursor under the coexistence of a nanometer-sized template in the solvent, and separating and collecting the obtained precipitation, and mesostructured oxide ceramics is prepared by employing the synthesizing method described above.Type: ApplicationFiled: September 6, 2001Publication date: March 14, 2002Applicant: Nat'l Inst. of Adv. Industrial Science and Tech.Inventors: Masahiko Inagaki, Atsushi Hozumi, Kei Teraoka, Kaori Nishizawa, Fukue Nagata, Yoshiyuki Yokogawa, Tetsuya Kameyama
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Patent number: 6153266Abstract: The present invention provides a method for producing a calcium phosphate coating film on the surface of a substrate, even a substrate which has poor heat resistance. The method comprises the steps of soaking a substrate in a first solution containing phosphate ions, inter alia, aqueous solutions of a basic phosphate salt such as Na.sub.3 PO.sub.4 or Na.sub.2 HPO.sub.4 ; removing the substrate and drying it; and soaking the substrate in a second solution (aqueous solution) containing calcium ions, to thereby obtain a coating film comprising hydroxyapatite or a mixture containing hydroxyapatite and a hydroxyapatite precursor. The substrate removed from the second solution may be soaked in a third solution (aqueous solution) containing an apatite component at a substantially saturated or supersaturated concentration, to thereby form a hydroxyapatite coating film. There may be used substrates formed of metals, ceramics, organic polymer materials, etc.Type: GrantFiled: December 7, 1998Date of Patent: November 28, 2000Assignees: Japan as represented by Director General Agency of Industrial Science and Technology, NGK Spark Plug Co., Ltd.Inventors: Yoshiyuki Yokogawa, Tetsuya Kameyama, Yukari Kawamoto, Kaori Nishizawa, Fukue Nagata, Kohji Okada, Hiroshi Sumi
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Patent number: 5698265Abstract: A method for the production of a composite consisting of cellulose fibers coated with a calcium phosphate compound consists essentially of phosphorylating the surface of cellulose fibers, immersing the surface-phosphorylated cellulose fibers in an aqueous solution containing calcium ions and hydroxyl ions, removing the cellulose fibers from the aqueous solution and subsequently immersing them in an aqueous solution containing calcium ions and phosphoric acid ions, and then removing the cellulose fibers from the aqueous solution. Also disclosed is a composite produced by the method.Type: GrantFiled: February 27, 1996Date of Patent: December 16, 1997Assignee: Agency of Industrial Science & Technology, Ministry of International Trade & IndustryInventors: Michael Roger Mucalo, Yoshiyuki Yokogawa, Motohiro Toriyama, Yukari Kawamoto, Takahiro Suzuki, Kaori Nishizawa, Fukue Nagata, Hajime Nagae
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Patent number: 5427754Abstract: A platelike hydroxyapatite is produced by preparing from a phosphate and a calcium salt an aqueous slurry of amorphous calcium phosphate having an atomic ratio of calcium atoms to phosphorus atoms in the range of 1.3:1 to 2.0:1, adding to the aqueous slurry not less than 10% by weight of alcohol based on the amount of the aqueous slurry, and subjecting the resultant mixture to a hydrothermal treatment.Type: GrantFiled: December 28, 1993Date of Patent: June 27, 1995Assignees: Agency Of Industrial Science & Technology, Ministry of International Trade & IndustryInventors: Fukue Nagata, Yoshiyuki Yokogawa, Motohiro Toriyama, Yukari Kawamoto, Takahiro Suzuki, Kaori Nishizawa, Hajime Nagae