Patents by Inventor Fulvio Uggeri

Fulvio Uggeri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Contrast Agents Endowed with High Relaxivity for Use in Magnetic Resonance Imaging (Mri) Which Contain a Chelating Moiety with Polyhydroxylated Substituents
    Publication number: 20070258905
    Abstract: The present invention relates to a new class of paramagnetic ion-based contrast agents of molecular weight lower than 3.5 kDa that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents and that are further characterized by a higher relaxivity.
    Type: Application
    Filed: June 28, 2005
    Publication date: November 8, 2007
    Applicant: Bracco Imaging SpA
    Inventors: Silvio Aime, Matteo Galli, Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri, Kondareddiar Ramalingam
  • Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
    Patent number: 6652834
    Abstract: Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: November 25, 2003
    Assignee: Bracco International B.V.
    Inventors: Pier Lucio Anelli, Luciano Lattuada, Fulvio Uggeri, Giovanna Lux, Michele Serleti, Milena Gabellini, Hervé Tournier
  • Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
    Patent number: 6461588
    Abstract: Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: October 8, 2002
    Assignee: Bracco Imaging S.p.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Christoph De Haen, Ornella Gazzotti, Luciano Lattuada, Giovanna Lux, Giuseppe Manfredi, Pierfrancesco Morosini, Daniela Palano, Michele Serleti, Fulvio Uggeri, Massimo Visigalli
  • Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
    Publication number: 20020098152
    Abstract: Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI)
    Type: Application
    Filed: December 14, 2001
    Publication date: July 25, 2002
    Applicant: Bracco International B.V.
    Inventors: Pier Lucio Anelli, Luciano Lattuada, Fulvio Uggeri, Giovanna Lux, Michele Serleti, Milena Gabellini, Herve Tournier
  • Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
    Patent number: 6342598
    Abstract: Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI). The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: January 29, 2002
    Assignee: Bracco International B.V.
    Inventors: Pier Lucio Anelli, Luciano Lattuada, Fulvio Uggeri, Giovanna Lux, Michele Serleti, Milena Gabellini, Hervé Tournier
  • Manganese chelates with high relaxivity in serum
    Patent number: 6337064
    Abstract: Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: January 8, 2002
    Assignee: Dibra S.p.A.
    Inventors: Marino Brocchetta, Luisella Calabi, Daniela Palano, Lino Paleari, Fulvio Uggeri
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: 6177562
    Abstract: Compounds of formulae (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: January 23, 2001
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: 6149890
    Abstract: Compounds of formulae (I) and (II) ##STR1## wherein the R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: November 21, 2000
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani
  • Benzyloxy derivatives of DTPA for MRI
    Patent number: 6099824
    Abstract: Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH.sub.2).sub.m --O--R.sub.2 group or hydrogen,R.sub.2 is a (C.sub.6 -C.sub.10) aryl, or an alkyl(C.sub.1 -C.sub.5)-aryl(C.sub.6 -C.sub.10) group, substituted or not by a group L corresponding to a OH group or a OR.sub.3 group, wherein R.sub.3 is a linear or branched (C.sub.1 -C.sub.5) alkyl group; or L is NH.sub.2, halogen, COOH or CONR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are independently hydrogen, or a linear or branched (C.sub.1 -C.sub.5) alkyl which can be substituted by 1-6 hydroxy groups and/or 1-6 alkoxy groups,R.sub.1 can have the same meanings as R, independently from it, except for hydrogen,Z is independently OH or OR.sub.6, or NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 are as previously defined, and R.sub.6 is a (C.sub.1 -C.sub.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: August 8, 2000
    Assignee: Dibra S.p.A.
    Inventors: Pier Lucio Anelli, Andrea Beltrami, Fulvio Uggeri, Mario Virtuani
  • Process for the manufacturing of iodinated contrast agents
    Patent number: 5763663
    Abstract: A process for the preparation of compounds of general formula (I) ##STR1## characterized in that the corresponding derivatives of general formula (II) ##STR2## are reacted with the compounds of general formula (III) ##STR3## wherein Z is halogen atom or a reactive residue of a sulfonic acid or a --N.sup.+ (R.sub.9).sub.3 cation wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group andR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6 R.sub.7 and R.sub.8 are as herein defined.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: June 9, 1998
    Assignee: Dibra S.p.A.
    Inventors: Lucio Pier Anelli, Marino Brocchetta, Ornella Gazzotti, Fulvio Uggeri
  • Process for the manufacturing of iodinated contrast agents
    Patent number: 5728877
    Abstract: A process for the preparation of compounds of general formula (I) ##STR1## characterized in that the corresponding derivatives of general formula (II) ##STR2## are reacted with the compounds of general formula (III) ##STR3## wherein Z is halogen atom or a reactive residue of a sulfonic acid or a --N.sup.+ (R.sub.9).sub.3 cation wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group andR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6 R.sub.7 and R.sub.8 are as herein defined.
    Type: Grant
    Filed: July 23, 1996
    Date of Patent: March 17, 1998
    Assignee: Dibra S.p.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Ornella Gazzotti, Fulvio Uggeri
  • Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
    Patent number: 5708166
    Abstract: This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: January 13, 1998
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier Lucio Anelli, Giuseppe Manfredi, Marino Brocchetta, Franco Fedeli
  • Biphenyl iodinated derivatives and their diagnostic use
    Patent number: 5663413
    Abstract: The invention relates to novel contrast media particularly useful for X-ray diagnostic investigations of human and animal body.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: September 2, 1997
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier Lucio Anelli, Marino Brocchetta, Massimo Visigalli
  • Iodinated paramagnetic chelates, and their use as contrast agents
    Patent number: 5660814
    Abstract: Novel compounds containing a polyiodinated aromatic or heteroaromatic residue and their chelate complexes with ions of metal elements with atomic number from 20 to 31, 39, from 42 to 44, 49 and from 57 to 83, and their salts with physiologically tolerable organic and inorganic bases are useful contrast agents for preparation of diagnostic formulations to obtain images of organs and/or tissues of human and animal body through the use of nuclear magnetic resonance or X-rays or the combination of both nuclear magnetic resonance and X-rays.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: August 26, 1997
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier Lucio Anelli, Franco Fedeli, Marcella Murru, Christoph De Haen
  • Paramagnetic metal icon chelates and use thereof as contrast agents in magnetic resonance imaging
    Patent number: 5649537
    Abstract: Novel paramagnetic metal ion chelates and their use as contrast agents in the diagnostic technique known as "magnetic resonance imaging" (M.R.I.) of the gastrointestinal tract and particularly of the liver, are described. The novel compounds result from the conjugation of a bile acid with a chelating agent and are capable of chelating the ions of bivalent and trivalent metals. The compounds have formula A-L-B in which A is the residue of a bile acid and derivatives of a bile acid, B is the residue of a chelating agent of a bivalent or trivalent metal ion having an atomic number of 20 to 31, 39, 42, 43, 44, 49, 57 to 83, L is a ligand between A and B.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: July 22, 1997
    Assignee: Dibra S.p.A.
    Inventors: Pier Lucio Anelli, Christoph De Haen, Luciano Lattuada, Pierfrancesco Morosini, Fulvio Uggeri
  • Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
    Patent number: 5622688
    Abstract: This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 22, 1997
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier L. Anelli, Giuseppe Manfredi, Marino Brocchetta, Franco Fedeli
  • Tetraiodopyrrole derivatives as contrast medium and as antiseptic
    Patent number: 5587487
    Abstract: The present invention refers to new contrast media particularly suited for X-ray diagnostic procedures of the human and animal body and also to the new compounds of general formulae (I) and (II).
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: December 24, 1996
    Assignee: Dibra S.p.A.
    Inventors: Christoph De Haen, Fulvio Uggeri, Ornella Gazzotti, Marino Brocchetta
  • Intermediates for chelating agents with prefixed symmetry and process for their preparation
    Patent number: 5539105
    Abstract: The preparation of compounds of formula (I), wherein R and R.sup.1 have the meanings specified in claim 1, is disclosed compounds (I) are useful intermediates for the preparation of chelating agents.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: July 23, 1996
    Assignee: DIBRA S.p.A.
    Inventors: Fulvio Uggeri, Pier L. Anelli, Marcella Murru, Mario Virtuani
  • 5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiodo-1,3-benzen edicarboxylamides), and contrast media containing them
    Patent number: 5464607
    Abstract: R.sub.2, R.sub.2 ', R.sub.3, and R.sub.3 ', which are the same or different, are one of the groups of formula --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH(OH) CH.sub.2 OH --CH(CH.sub.2 OH)CH(OH)CH.sub.2 OH, --CH.sub.2 (CHOH).sub.4 CH.sub.2 OH, or --CH(CH.sub.2 OH).sub.2 ; and X is one of the groups --CH(OH)--, --CH(CH.sub.2 OH)--, --C(OH) (CH.sub.2 OH)--, or --C(CH.sub.2 OH).sub.2 --, are useful as opacifying components for X-ray contrast media.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: November 7, 1995
    Assignee: Dibra S.p.A.
    Inventors: Pierlucio Anelli, Marino Brocchetta, Fulvio Uggeri, Massimo Visigalli
  • Chelated complexes of paramagnetic metals with low toxicity
    Patent number: RE38329
    Abstract: Compounds of formula (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: November 25, 2003
    Assignee: Bracco Imaging S.p.A.
    Inventors: Fulvio Uggeri, Franco Fedeli, Alessandro Maiocchi, Maurizio Franzini, Mario Virtuani