Patents by Inventor Fumihide Sakai

Fumihide Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microorganism for BBM 928 production
    Patent number: 4780416
    Abstract: The actinomycete "Actinomadura sp." designated in our culture collection as Strain No. G455-101 has been deposited with the American Type Culture Collection under the Accession Number ATCC No. 31491. The taxonomic description of this microorganism is presented in detail in the specification as are instructions for fermenting aqueous nutrient media with it to produce the BBM 928 antibiotic complex. The BBM 928 complex has utility as an antibacterial agent against gram-positive and acid fast bacteria and exhibits antitumor activity against experimental animal tumors.
    Type: Grant
    Filed: December 18, 1986
    Date of Patent: October 25, 1988
    Assignee: Bristol-Myers Company
    Inventors: Hideo Koshiyama, Fumihide Sakai, Hiroaki Ohkuma
  • Fermentation process for BBM-928
    Patent number: 4631256
    Abstract: BBM-928 is a mixture of antitumor antibacterial substances produced by fermentation of Actinomadura sp., ATCC No. 31491, under controlled conditions. The components may be separated by silica gel thin layer chromatography and by other means.
    Type: Grant
    Filed: October 6, 1983
    Date of Patent: December 23, 1986
    Assignee: Bristol-Myers Company
    Inventors: Hideo Koshiyama, Fumihide Sakai, Hiroaki Ohkuma
  • Biologically pure culture of Actinomadura Sp.
    Patent number: 4546084
    Abstract: A biologically pure culture of Actinomadura Sp. Strain H710-49 (ATCC 39144) is provided. The antibiotic designated BBM-1644 may be produced by fermentation of the subject culture.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: October 8, 1985
    Assignee: Bristol-Myers Company
    Inventors: Masataka Konishi, Fumihide Sakai, Takeo Miyaki, Hiroshi Kawaguchi
  • Antitumor antibacterial agents
    Patent number: 4451456
    Abstract: An antitumor antibacterial complex referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram-negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: May 29, 1984
    Assignee: Bristol-Myers Company
    Inventors: Hideo Koshiyama, Fumihide Sakai, Hiroaki Ohkuma
  • Antitumor antibacterial agents
    Patent number: 4360458
    Abstract: An antitumor antibacterial complex referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram-negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.
    Type: Grant
    Filed: March 6, 1980
    Date of Patent: November 23, 1982
    Assignee: Bristol-Myers Company
    Inventors: Hideo Koshiyama, Fumihide Sakai, Hiroaki Ohkuma