Patents by Inventor Fumihiko Akahoshi

Fumihiko Akahoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proline derivatives and use thereof as drugs
    Patent number: 7060722
    Abstract: The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the ?-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: June 13, 2006
    Assignee: Mitsubishi Pharma Corporation
    Inventors: Hiroshi Kitajima, Hiroshi Sakashita, Fumihiko Akahoshi, Yoshiharu Hayashi
  • Proline derivatives and use thereof as drugs
    Publication number: 20050245538
    Abstract: The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the ?-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
    Type: Application
    Filed: June 2, 2005
    Publication date: November 3, 2005
    Inventors: Hiroshi Kitajima, Hiroshi Sakashita, Fumihiko Akahoshi, Yoshiharu Hayashi
  • Thiazolidine derivative and medicinal use thereof
    Publication number: 20040259883
    Abstract: A thiazolidine derivative represented by the formula (I) 1
    Type: Application
    Filed: April 21, 2004
    Publication date: December 23, 2004
    Inventors: Hiroshi Sakashita, Tomohiro Yoshida, Hiroshi Kitajima, Masahiro Takeuchi, Yoshihito Tanaka, Takuya Yoshimura, Fumihiko Akahoshi, Yoshiharu Hayashi
  • Proline derivatives and the use thereof as drugs
    Publication number: 20040106655
    Abstract: The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products.
    Type: Application
    Filed: February 10, 2003
    Publication date: June 3, 2004
    Inventors: Hiroshi Kitajima, Hiroshi Sakashita, Fumihiko Akahoshi, Yoshiharu Hayashi
  • Heterocyclic amide compounds and medicinal uses thereof
    Patent number: 6080738
    Abstract: A heterocyclic amide compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and a pharmaceutical use thereof. The heterocyclic amide compound and a pharmacologically acceptable salt thereof of the present invention have superior inhibitory action on chymase group in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be used for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: June 27, 2000
    Assignee: Yoshitomi Pharmaceuticals Industries, Ltd.
    Inventors: Fumihiko Akahoshi, Atsuyuki Ashimori, Takuya Yoshimura, Masahiro Eda, Hiroshi Sakashita, Masahide Nakajima, Teruaki Imada
  • Heterocyclic amide compounds and pharmaceutical use of the same
    Patent number: 5948785
    Abstract: Heterocyclic amide compounds of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and pharmaceutical use thereof. The heterocyclic amide compounds and pharmacologically acceptable salts thereof of the present invention have superior inhibitory activity against chymase groups in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be effective for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: September 7, 1999
    Assignee: The Green Cross Corporation
    Inventors: Fumihiko Akahoshi, Takuya Yoshimura, Masahiro Eda, Atsuyuki Ashimori, Hajime Fukuyama, Masahide Nakajima, Teruaki Imada, Hideki Okunishi, Mizuo Miyazaki
  • Triazole derivative and pharmaceutical use thereof
    Patent number: 5750545
    Abstract: An agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, an agent for the prophylaxis and treatment of allergic diseases, an agent for the prophylaxis and treatment of eosinophil-related diseases and an eosinophilia inhibitor, comprising, as an active ingredient, a series of triazole derivatives of the following formula (I) ##STR1## or the following formula (III) ##STR2## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. A novel monocyclic or bicyclic triazole derivative. The agent for the prophylaxis and treatment of immune-related diseases, in particular, immunosuppressant, the agent for the prophylaxis and treatment of allergic diseases, the agent for the prophylaxis and treatment of eosinophil-related diseases, the eosinophilia inhibitor and the novel triazole derivative of the present invention all, have superior eosinophilia-inhibitory action and lymphocyte activation-inhibitory action.
    Type: Grant
    Filed: January 23, 1996
    Date of Patent: May 12, 1998
    Assignee: The Green Cross Corporation
    Inventors: Fumihiko Akahoshi, Takehiro Okada, Shinji Takeda, Youichiro Naito, Chikara Fukaya, Shigeki Kuwahara, Masahiko Kajii, Hiroko Nishimura, Masanori Sugiura