Patents by Inventor Fumihiro Fujiki

Fumihiro Fujiki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigen-specific helper T-cell receptor genes
    Patent number: 11091531
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: August 17, 2021
    Assignee: International Institute of Cancer Immunology, Inc.
    Inventors: Haruo Sugiyama, Fumihiro Fujiki
  • Method for modifying T cell population
    Patent number: 10947503
    Abstract: Provided is a method for increasing the proportion of memory T cells in a T cell population, said method comprising a step of adding a modulator for the retinoid metabolic pathway and/or a modulator for the retinoic acid signaling system to the T cell population.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: March 16, 2021
    Assignee: International Institute of Cancer Immunology, Inc.
    Inventors: Haruo Sugiyama, Fumihiro Fujiki
  • ANTIGEN-SPECIFIC HELPER T-CELL RECEPTOR GENES
    Publication number: 20210070832
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Application
    Filed: October 22, 2020
    Publication date: March 11, 2021
    Inventors: Haruo SUGIYAMA, Fumihiro FUJIKI
  • Method for modifying T cell population
    Patent number: 10899790
    Abstract: Provided are: a compound represented by formula (I); a retinoid metabolic pathway inhibitor comprising the same; an agent for increasing the ratio of memory T cells; a prophylactic and/or therapeutic agent for cancer or an infectious disease; a cancer immunotherapeutic adjuvant; an immunopotentiator; and a method for preparing a T cell population wherein the ratio of memory T cells is increased, said method comprising using the compound of formula (I).
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: January 26, 2021
    Assignees: OSAKA UNIVERSITY, KNC LABORATORIES CO., LTD.
    Inventors: Haruo Sugiyama, Fumihiro Fujiki, Masahiro Neya, Shinya Kohno
  • Antigen-specific helper T-cell receptor genes
    Patent number: 10815288
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: October 27, 2020
    Assignee: International Institute of Cancer Immunology, Inc.
    Inventors: Haruo Sugiyama, Fumihiro Fujiki
  • Antigen-specific helper T-cell receptor genes
    Patent number: 10752669
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: August 25, 2020
    Assignee: International Institute of Cancer Immunology, Inc.
    Inventors: Haruo Sugiyama, Fumihiro Fujiki
  • METHOD FOR MODIFYING T CELL POPULATION
    Publication number: 20190284228
    Abstract: Provided are: a compound represented by formula (I); a retinoid metabolic pathway inhibitor comprising the same; an agent for increasing the ratio of memory T cells; a prophylactic and/or therapeutic agent for cancer or an infectious disease; a cancer immunotherapeutic adjuvant; an immunopotentiator; and a method for preparing a T cell population wherein the ratio of memory T cells is increased, said method comprising using the compound of formula (I).
    Type: Application
    Filed: November 8, 2017
    Publication date: September 19, 2019
    Applicants: OSAKA UNIVERSITY, KNC LABORATORIES CO., LTD.
    Inventors: Haruo SUGIYAMA, Fumihiro FUJIKI, Masahiro NEYA, Shinya KOHNO
  • ANTIGEN-SPECIFIC HELPER T-CELL RECEPTOR GENES
    Publication number: 20190135893
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Application
    Filed: October 17, 2018
    Publication date: May 9, 2019
    Inventors: Haruo SUGIYAMA, Fumihiro FUJIKI
  • METHOD FOR MODIFYING T CELL POPULATION
    Publication number: 20170369841
    Abstract: Provided is a method for increasing the proportion of memory T cells in a T cell population, said method comprising a step of adding a modulator for the retinoid metabolic pathway and/or a modulator for the retinoic acid signaling system to the T cell population.
    Type: Application
    Filed: December 22, 2015
    Publication date: December 28, 2017
    Applicant: International Institute of Cancer Immunology, Inc.
    Inventors: Haruo SUGIYAMA, Fumihiro FUJIKI
  • ANTIGEN-SPECIFIC HELPER T-CELL RECEPTOR GENES
    Publication number: 20160009781
    Abstract: The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 14, 2016
    Inventors: Haruo Sugiyama, Fumihiro Fujiki