Abstract: A manipulation apparatus and a manipulation method for performing culturing, manipulation, and analysis of minute samples such as cells and microbes on a large scale, the manipulation apparatus including a stage unit on which a predetermined cell incubator is mounted and a probe array unit having a plurality of probes. The probe array unit includes a first probe array and a second probe array. The first probe array includes a plurality of probes arranged side by side at a predetermined pitch along the X-axis direction. The second probe array includes a plurality of probes arranged side by side at a predetermined pitch along the Y-axis direction.