Patents by Inventor Fumihito Arai

Fumihito Arai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200337757
    Abstract: Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage.
    Type: Application
    Filed: May 27, 2020
    Publication date: October 29, 2020
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yoko YAMANISHI, Shinya SAKUMA, Hiroki KURIKI, Fumihito ARAI
  • Patent number: 10716610
    Abstract: Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: July 21, 2020
    Assignee: Japan Science and Technology Agency
    Inventors: Yoko Yamanishi, Shinya Sakuma, Hiroki Kuriki, Fumihito Arai
  • Publication number: 20200179918
    Abstract: A dispensing apparatus, a liquid dispensing method, and a cell dispensing method which can dispense liquid with very high accuracy. A dispensing apparatus includes a glass pipette, a tubular elastic member, a rod-shaped member, and a piezoelectric element actuator. A portion of the tubular elastic member located adjacent to a first open end thereof covers a portion of the glass pipette located adjacent to an opening portion thereof. A portion of the tubular elastic member located adjacent to a second open end thereof covers at least a forward end portion of the rod-shaped member. When the piezoelectric element actuator pushes the rod-shaped member toward the opening portion of the glass pipette, the tubular elastic member deforms such that the volume of the internal space of the tubular elastic member decreases.
    Type: Application
    Filed: June 19, 2018
    Publication date: June 11, 2020
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Shinya SAKUMA, Yusuke KASAI, Fumihito ARAI
  • Patent number: 10669525
    Abstract: Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 2, 2020
    Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Utako Yokoyama, Yoshihiro Ishikawa, Makoto Kaneko, Shinya Sakuma, Fumihito Arai
  • Publication number: 20200135056
    Abstract: A simulated eyeball for training in ophthalmic surgery includes a simulated sclera region that constitutes a simulated sclera, and a conductor layer that is formed on a side of the simulated sclera region that is on an interior of the simulated eyeball, the conductor layer forming a simulated choroid region.
    Type: Application
    Filed: November 30, 2017
    Publication date: April 30, 2020
    Inventors: Seiji OMATA, Fumihito ARAI
  • Patent number: 10612155
    Abstract: Provided are a protein crystal device and method for crystallizing protein capable of generating protein crystal without imparting a heat effect, a protein crystal-cutting device and method for cutting protein crystal capable of cutting protein crystal without imparting a heat effect on protein crystal, and bubble-jetting member and protein-adsorbing-bubble-jetting member used in said device. A bubble-jetting member is used in a protein crystal device to jet bubbles into a protein solution to thereby allow protein crystals to be obtained, the bubble-jetting member comprising: a core formed of a conductive material; a shell part formed of an insulating material, including an extended section extending from the tip of the core, and in which at least a portion closely adheres to the core to cover the core; and a gap having a bubble-jetting port, the gap being formed between the extended section and the tip of the core.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: April 7, 2020
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yoko Yamanishi, Fumihito Arai, Hiroki Kuriki
  • Publication number: 20190362654
    Abstract: The invention provides an inner limiting membrane peeling model that is used in procedure training in peeling of the inner limiting membrane. The model has: a simulated retina and a simulated inner limiting membrane formed on the simulated retina. The simulated inner limiting membrane is formed of a hydrophilic polymer gel that is formed mainly of a water-soluble polymer. At least when used in the above procedure training, the model is disposed with the simulated inner limiting membrane immersed in water or an aqueous solution containing a predetermined solute.
    Type: Application
    Filed: November 16, 2017
    Publication date: November 28, 2019
    Applicant: National University Corporation Nagoya University
    Inventors: Seiji Omata, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai
  • Publication number: 20190301950
    Abstract: In a load sensor detecting a magnitude of an external load applied in a direction parallel to a sheet shape of a sheet-shaped quartz crystal resonator, the load sensor comprising: a quartz crystal resonator layer including the sheet-shaped quartz crystal resonator and a pair of electrode portions on a pair of surfaces opposite to each other in a plate thickness direction of the quartz crystal resonator; and a pair of holding layers disposed to sandwich both sides of the sheet shape of the quartz crystal resonator layer and causing a displacement in substantially the same amount as the quartz crystal resonator layer when the external load is applied to the quartz crystal resonator layer, the holding layers and the quartz crystal resonator layer are made of materials having substantially equivalent rates of thermal expansion.
    Type: Application
    Filed: June 2, 2017
    Publication date: October 3, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Fumihito ARAI, Yuichi MUROZAKI, Shinya SAKUMA
  • Patent number: 10317397
    Abstract: Provided is a microparticle separation system capable of continuously separating microparticles from a solution in a short period of time in which microparticles having different particle diameters are mixed, without the need to use antibodies or the like. The microparticle separation system comprises a microparticle separation chip; a thin plate for a sample liquid; a thin plate for a sheath liquid; and suctioning means and/or a suctioning device for suctioning the sheath liquid; and the microparticle separation chip comprises a single capture site for capturing to-be-captured microparticles being formed using the at least three pillars having one end provided on the substrate and the other end open upward.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: June 11, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Fumihito Arai, Taisuke Masuda, Woneui Song
  • Publication number: 20190071630
    Abstract: A cell sorting device is characterized by including: a main flow channel (14) through which a liquid containing a row of cells including a target cell flows, and in which a cell separation area for separating the target cell from the row of cells is provided at a halfway position in a flow direction, the main flow channel being formed in a substrate (12); a selection flow channel (16) into which the target cell is pushed out from the main flow channel, the selection flow channel being formed in the substrate so as to branch from the main flow channel downstream of the cell separation area; a sub flow channel (18) through which a separating liquid flows, the separating liquid being for separating the target cell from the row of cells and pushing out the target cell into the selection flow channel, the sub flow channel being formed in the substrate so as to intersect with the main flow channel in the cell separation area; a pair of liquid flow generating members (22) for generating a liquid flow of the separati
    Type: Application
    Filed: March 6, 2017
    Publication date: March 7, 2019
    Inventors: Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai
  • Patent number: 9968932
    Abstract: Provided is a microchannel chip, for microparticle separation, which can continuously separate microparticles, from a solution in which microparticles of different particle diameter are mixed, without needing to use an antibody or similar, and without causing clogging. Also provided are a microparticle separation method and a system for microparticle separation using the chip. Microparticles can be captured by using the microchannel chip for microparticle separation, the microchannel chip being characterised by being provided with a plurality of main channels and capture portions that are wider than the main channels and at least one of which is provided to each main channel.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: May 15, 2018
    Assignee: National University Corporation Nagoya University
    Inventors: Fumihito Arai, Taisuke Masuda, Miyako Niimi, Haruki Douke, Hayao Nakanishi, Seiji Ito
  • Publication number: 20170218329
    Abstract: Means which enables preparation of a thick cell aggregate by a simple process without an operation of detaching and stacking of cells is disclosed. The method for preparing a three-dimensional cell aggregate by the present invention comprises: a cell encasing step of placing a cell suspension in a cell container; and a pressure application step of applying pressure to cells in the container. The cell encasing step and the pressure application step may be carried out a plurality of times. By the present invention, a thick, robust cell aggregate can be obtained by a simple operation of applying pressure to a cell suspension or a medium containing cells. Since the method does not require an operation of stacking a plurality of cell sheets, the cells are hardly damaged, and the conditions of the cells can be favorably maintained, so that the cells can be advantageously used as a tissue piece for transplantation.
    Type: Application
    Filed: September 29, 2015
    Publication date: August 3, 2017
    Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Utako YOKOYAMA, Yoshihiro ISHIKAWA, Makoto KANEKO, Shinya SAKUMA, Fumihito ARAI
  • Publication number: 20170122937
    Abstract: Provided is a microparticle separation system capable of continuously separating microparticles from a solution in a short period of time in which microparticles having different particle diameters are mixed, without the need to use antibodies or the like. The microparticle separation system comprises a microparticle separation chip; a thin plate for a sample liquid; a thin plate for a sheath liquid; and suctioning means and/or a suctioning device for suctioning the sheath liquid; and the microparticle separation chip comprises a single capture site for capturing to-be-captured microparticles being formed using the at least three pillars having one end provided on the substrate and the other end open upward.
    Type: Application
    Filed: April 9, 2015
    Publication date: May 4, 2017
    Applicants: National University Corporation Nagoya University, National University Corporation Nagoya University
    Inventors: Fumihito ARAI, Taisuke MASUDA, Woneui SONG
  • Publication number: 20160208405
    Abstract: Provided are a protein crystal device and method for crystallizing protein capable of generating protein crystal without imparting a heat effect, a protein crystal-cutting device and method for cutting protein crystal capable of cutting protein crystal without imparting a heat effect on protein crystal, and bubble-jetting member and protein-adsorbing-bubble-jetting member used in said device. A bubble-jetting member is used in a protein crystal device to jet bubbles into a protein solution to thereby allow protein crystals to be obtained, the bubble-jetting member comprising: a core formed of a conductive material; a shell part formed of an insulating material, including an extended section extending from the tip of the core, and in which at least a portion closely adheres to the core to cover the core; and a gap having a bubble-jetting port, the gap being formed between the extended section and the tip of the core.
    Type: Application
    Filed: August 27, 2014
    Publication date: July 21, 2016
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Yoko YAMANISHI, Fumihito ARAI, Hiroki KURIKI
  • Publication number: 20150246353
    Abstract: Provided is a microchannel chip, for microparticle separation, which can continuously separate microparticles, from a solution in which microparticles of different particle diameter are mixed, without needing to use an antibody or similar, and without causing clogging. Also provided are a microparticle separation method and a system for microparticle separation using the chip. Microparticles can be captured by using the microchannel chip for microparticle separation, the microchannel chip being characterised by being provided with a plurality of main channels and capture portions that are wider than the main channels and at least one of which is provided to each main channel.
    Type: Application
    Filed: October 15, 2013
    Publication date: September 3, 2015
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Fumihito Arai, Taisuke Masuda, Miyako Niimi, Haruki Douke, Hayao Nakanishi, Seiji Ito
  • Publication number: 20150011930
    Abstract: Provided are a device whereby, during process of a process target such as a cell or the like, localized process of a process part is possible without inflicting damage due to heat, and rejoining and regeneration may proceed readily subsequent to process, and whereby an injection substance may be introduced efficiently; and a device for generating bubbles containing a plasma. Through the use of a localized ablation device employing a bubble jetting member having a core formed from a conductive material, a shell part formed from an insulating material, covering the core and including a section extending from the tip of the core, and a space formed between the extended section of the shell part and the tip of the core, a process target can be treated in localized fashion and without inflicting damage.
    Type: Application
    Filed: March 1, 2013
    Publication date: January 8, 2015
    Applicant: Japan Science and Technology Agency
    Inventors: Yoko Yamanishi, Shinya Sakuma, Hiroki Kuriki, Fumihito Arai
  • Patent number: 7824854
    Abstract: A substance (for example, methylcellulose) that undergoes a reversible gel to sol phase transition is utilized in a recovery method for specific micromaterials such as DNA molecules, cells, microorganisms and the like, approximately several ?m in size, from a mixture containing other micromaterials, and a micromaterial is accurately and conveniently recovered. The present invention is a method of recovering a desired micromaterial in a system comprising a medium that undergoes a reversible phase transition between a sol and a gel, a support material and micromaterials, comprising the steps of converting the medium surrounding the micromaterial to be recovered into a gel locally to immobilize said micromaterial on said support along with the gelled medium, removing the medium and micromaterials not immobilized on said support material and converting the gelled medium to a sol to recover the micromaterial.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: November 2, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Fumihito Arai, Toshio Fukuda, Akihiko Ichikawa, Tohoru Katsuragi
  • Publication number: 20050208465
    Abstract: A substance (for example, methylcellulose) that undergoes a reversible gel to sol phase transition is utilized in a recovery method for specific micromaterials such as DNA molecules, cells, microorganisms and the like, approximately several ?m in size, from a mixture containing other micromaterials, and a micromaterial is accurately and conveniently recovered. The present invention is a method of recovering a desired micromaterial in a system comprising a medium that undergoes a reversible phase transition between a sol and a gel, a support material and micromaterials, comprising the steps of converting the medium surrounding the micromaterial to be recovered into a gel locally to immobilize said micromaterial on said support along with the gelled medium, removing the medium and micromaterials not immobilized on said support material and converting the gelled medium to a sol to recover the micromaterial.
    Type: Application
    Filed: January 14, 2003
    Publication date: September 22, 2005
    Inventors: Fumihito Arai, Toshio Fukuda, Akihiko Ichikawa, Tohoru Katsuragi
  • Publication number: 20050186361
    Abstract: A three-dimensional model, wherein coelom models such as blood vessels are stackingly molded based on tomogram data on a subject, the peripheries of the coelom models are surrounded by a three-dimensional model forming material, the three-dimensional model forming material is hardened, and the coelom models are fused or molten and removed, whereby a specified three-dimensional model can be formed.
    Type: Application
    Filed: May 1, 2003
    Publication date: August 25, 2005
    Inventors: Toshio Fukuda, Fumihito Arai, Seiichi Ikeda, Makoto Negoro
  • Patent number: 6262516
    Abstract: A parallel plate structure (1) is provided with a pair of bimorph piezoelectric elements (2) and prismatic insulation spacers (3) inserted between the piezoelectric elements (2) at the upper and lower ends thereof for cementing the piezoelectric elements (2) together via the spacers (3). Each piezoelectric element (2) comprises a planar base material (4) of titanium, PZT thin films (5) formed on both sides of the base material (4) by the hydrothermal method, and electrode films (6) formed on the PZT thin films (5). The base material (4) is 20 &mgr;m thick and the PZT thin films (5) are several pm thick, while the aluminum electrode films (6) are several um thick.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: July 17, 2001
    Assignee: Kabushiki Kaisha Tokai Rika Denki Seisakusho
    Inventors: Toshio Fukuda, Fumihito Arai, Koichi Itoigawa, Hitoshi Iwata