Patents by Inventor Fumihito Sugihara
Fumihito Sugihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10632177Abstract: A peptide selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly and Pro-Hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.Type: GrantFiled: October 20, 2016Date of Patent: April 28, 2020Assignee: NITTA GELATIN INC.Inventors: Seiko Koizumi, Fumihito Sugihara, Naoki Inoue
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Publication number: 20170035858Abstract: A peptide selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly and Pro-Hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.Type: ApplicationFiled: October 20, 2016Publication date: February 9, 2017Inventors: Seiko Koizumi, Fumihito Sugihara, Naoki Inoue
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Publication number: 20160082087Abstract: A peptide selected from the group consisting of Hyp-Gly, Pro-Ala-Gly, Gly-Pro, Glu-Hyp-Gly, (Pro-Hyp-Gly)5, (Pro-Hyp-Gly)2, Pro-Hyp-Gly, Glu-Hyp, Ala-Hyp-Gly, Ser-Hyp-Gly and Phe-Hyp or a pharmaceutically acceptable salt thereof is useful as a whitening promoting agent or atopic dermatitis ameliorating agent.Type: ApplicationFiled: March 31, 2014Publication date: March 24, 2016Inventors: Seiko KOIZUMI, Fumihito SUGIHARA, Naoki INOUE
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Publication number: 20150315234Abstract: A peptide selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly and Pro-Hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.Type: ApplicationFiled: December 12, 2013Publication date: November 5, 2015Applicant: NITTA GELATIN INC.Inventors: Seiko Koizumi, Fumihito Sugihara, Naoki Inoue
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Patent number: 9061003Abstract: A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modified substances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.Type: GrantFiled: January 25, 2012Date of Patent: June 23, 2015Assignee: NITTA GELATIN INC.Inventors: Fumihito Sugihara, Naoki Inoue, Seiko Koizumi, Tadashi Yoshimoto, Hiroshi Oyama
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Publication number: 20140024596Abstract: At least one peptide molecule selected from EGDGHLGKPGROGE (SEQ ID NO:1), EKDGHPGKPGROGE (SEQ ID NO:2), G(POG)4, (POG)3, G(POG)2, (POG)2, (POG)4, (POG)5 and G(POG)3, and pharmaceutically acceptable salts thereof is effective for inhibiting various diseases such as osteoporosis, osteoarthritis and pressure ulcer. The peptide molecule is easily absorbed into a body and migrates into cells in an intestinal tract, and strongly binds to a nucleic acid compound or the like to form a complex, and thus functions well as a carrier component for delivering the nucleic acid compound or the like without causing the problems associated with conventional DDS techniques.Type: ApplicationFiled: June 11, 2013Publication date: January 23, 2014Inventors: Fumihito SUGIHARA, Naoki INOUE, Hiroshi MANO
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Publication number: 20130303448Abstract: A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modified substances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.Type: ApplicationFiled: January 25, 2012Publication date: November 14, 2013Applicant: NITTA GELATIN INC.Inventors: Fumihito Sugihara, Naoki Inoue, Seiko Koizumi, Tadashi Yoshimoto, Hiroshi Oyama
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Patent number: 8410062Abstract: A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.Type: GrantFiled: June 14, 2012Date of Patent: April 2, 2013Assignee: Nitta Gelatin Inc.Inventors: Fumihito Sugihara, Naoki Inoue, Seiko Koizumi, Chinfang Liu, Hajime Takasaki, Hisayuki Kobayashi, Hiroshi Mano, Sachie Nakatani, Masahiro Wada
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Publication number: 20120258919Abstract: A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.Type: ApplicationFiled: June 14, 2012Publication date: October 11, 2012Applicant: NITTA GELATIN INC.Inventors: Fumihito SUGIHARA, Naoki INOUE, Seiko KOIZUMI, Chinfang LIU, Hajime TAKASAKI, Hisayuki KOBAYASHI, Hiroshi MANO, Sachie NAKATANI, Masahiro WADA
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Patent number: 8227424Abstract: A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.Type: GrantFiled: November 14, 2008Date of Patent: July 24, 2012Assignee: Nitta Gelatin Inc.Inventors: Fumihito Sugihara, Naoki Inoue, Seiko Koizumi, Chinfang Liu, Hajime Takasaki, Hisayuki Kobayashi, Hiroshi Mano, Sachie Nakatani, Masahiro Wada
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Publication number: 20110166365Abstract: A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.Type: ApplicationFiled: November 14, 2008Publication date: July 7, 2011Applicant: NITTA GELATIN INC.Inventors: Fumihito Sugihara, Naoki Inoue, Seiko Koizumi, Chinfang Liu, Hajime Takasaki, Hisayuki Kobayashi, Hiroshi Mano, Sachie Nakatani, Masahiro Wada
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Publication number: 20100068342Abstract: An object of the present invention is to elucidate a collagen peptide composed of oligopeptides having ability to enter the blood higher than that of conventional collagen peptides and thus to provide a food or beverage mixed with the collagen peptide. The present invention provides a collagen peptide composition obtainable by digesting a collagen or gelatin with protease, which comprises 70% to 100% by weight of peptides with a molecular weight 500 or more to 3000 or less, less than 10% by weight of peptides with a molecular weight of less than 500, and less than 20% by weight of peptides with a molecular weight of more than 3000, based on the total weight of the composition, wherein the ratio of N-terminal glycine residues to total of the N-terminal amino acid residues of the peptides in the composition is 33 mol % or more to 65 mol % or less.Type: ApplicationFiled: November 15, 2007Publication date: March 18, 2010Applicant: Meji Seika Kaisha LtdInventors: Hitoshi Matsumoto, Hiroki Ohara, Takanori Nakajima, Fumihito Sugihara, Hajime Takasaki
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Patent number: 5342441Abstract: A hardenable, biocompatible composition for repairing firm living tissue which includes a powder component containing Ca.sub.4 P.sub.2 O.sub.9 and at least one of CaHPO.sub.4 and CaHPO.sub.4.H.sub.2 O at a molar ratio of Ca:P of 1.16-1.95; and a liquid component containing 1 mM to 2M of a second phosphate ion and 1 mM to 2M of an organic ion. The weight ratio of the powder component to the liquid component is 0.5-4.0.Type: GrantFiled: June 22, 1992Date of Patent: August 30, 1994Assignee: Nitta Gelatin Inc.Inventors: Yoshinobu Mandai, Kohji Nagatomi, Kazuhiko Minamigawa, Fumihito Sugihara
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Patent number: 5238491Abstract: This invention relates to a hardening material for medical and dental use which is composed of a powder of calcium phosphate and a hardening liquid.A subject of the present invention is to provide a hardening material wherein a calcified hard tissue analogous to body hard tissue capable of making chemically a sufficient bond with body hard tissue is formed in a body within relatively short time passage.To attain the above-described objective, the hardening material for medical and dental use relating to the present invention is composed of a calcium phosphate powder and a hardening liquid and also of at least either one of collagen and/or collagen derivatives in a state of powder or solution, and the calcium phosphate powder contains a powder of .alpha.-tricalcium phosphate [.alpha.-Ca.sub.3 (PO.sub.4).sub.2 ]and/or tetracalcium phosphate [Ca.sub.4 (PO.sub.4).sub.2 O] as an essential component and the hardening liquid comprises at least one acid selected from inorganic acids and acetic acid.Type: GrantFiled: March 21, 1990Date of Patent: August 24, 1993Assignee: Nitta Gelatin Inc.Inventors: Fumihito Sugihara, Takashi Ishii, Tooru Kurihara
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Patent number: 5223029Abstract: This invention relates to a hardening material for medical and dental use, in which at least either one or both of .alpha.-tricalcium phosphate and tetracalcium phosphate as an essential component and, as a hardening adjuster, the following 1 tannin, 2 tannin and collagen, 3 collagen and an organic acid, 4 tannin, collagen, and an organic acid, 5 tannin and an organic acid, or 6 at least two kinds or organic acids.Type: GrantFiled: April 9, 1990Date of Patent: June 29, 1993Assignee: Nitta Gelatin Inc.Inventors: Hironobu Oonishi, Fumihito Sugihara, Takashi Ishii, Kaneo Suzuki, Seiko Hata, Toshikazu Takano