Abstract: A grouting pipe with a vibration function includes: a grouting pipe body provided with a hydraulic control structure, a vibration structure and a grouting hole control structure; wherein the vibration structure is rotatably arranged inside the grouting pipe body, and the hydraulic control structure is provided outside the grouting pipe body; the grouting hole control structure is provided on an internal wall of the grouting pipe body, and the hydraulic control structure is connected to the grouting hole control structure through a first hydraulic pipe. The grouting pipe solves the technical problems that conventional grouting pipes may be blocked by sandy soil during a press-in process, and it is difficult for the slurry to diffuse.

Abstract: A vibratory grouting drilling rig includes: a drilling rig bracket, a moving bracket, and a driving mechanism mounted on the drilling rig bracket for driving the moving bracket to move; wherein a working bracket is slidingly mounted on the moving bracket, and a sliding direction of the working bracket is identical to a moving direction of the moving bracket; a vibratory grouting rod and a drilling rod are mounted on the working bracket; multiple flexible connectors are connected between the working bracket and the drilling rig bracket, and are arranged along the moving direction of the moving bracket; the flexible connectors go around an end of the moving bracket and are connected to the drilling rig bracket. When the moving bracket moves, the flexible connectors pull the working bracket to move relative to the moving bracket, thus providing extra drilling force.

Abstract: The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 ?M, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.

Abstract: An (A) additive organopolysiloxane composition is disclosed, which includes (A1) a branched organopolysiloxane polymer comprising M, D and Q siloxy units, (A2) a silicone resin, and (A3) a polydiorganosiloxane oligomer. A curable composition is also disclosed, the curable composition including the (A) additive organopolysiloxane composition, (B) an organosilicon compound having at least two silicon-bonded hydrogen atoms per molecule, and (C) a hydrosilylation catalyst. A method of preparing the curable composition, and a method of forming a film with the curable composition are also disclosed. The compositions and methods are useful for forming silicone release coatings with high release force.

Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.

Abstract: Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.

Abstract: A therapeutic composition includes a polysaccharide, isolated from a member of the genus Cucurbita, e.g., pumpkin, having a backbone including alternating ?-L-rhamnosyl (?-L-Rhap) and ?-D-galactopyranosyluronic acid (?-D-GapA) residues, and a side chain attached to the backbone including ?-D-galactan (?-D-Galp), ?-L-arabinofuranosyl (?-L-Araf), or combinations thereof, and a pharmaceutically acceptable excipient. A ?-D-Galp side chain is attached to the backbone at the C-4 carbon of at least one ?-L-Rhap of the backbone. At least one ?-L-Araf is attached to the ?-D-Galp side chain. The ?-L-Araf is attached to the ?-D-Galp side chain via the C-3 carbon of the ?-D-Galp. The polysaccharide is effective for treating a galectin-3 dependent disorder by binding to the carbohydrate recognition domain of galectin-3, resulting in inhibition of galectin-3 activity.

Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.

Abstract: Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.