Abstract: What is aimed at is to provide a topical preparation that contains tacrolimus as an active pharmaceutical ingredient, has high stability and transdermal absorbability of the active pharmaceutical ingredient, is less irritating, and has a good feeling of use. The present invention relates to a liquid topical preparation that contains (i) tacrolimus, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, and (ii) at least one ketone, and that is substantially free of ethanol. It is preferable that the liquid topical preparation further contains at least one fatty acid ester and fluid paraffin, and is substantially free of water.