Abstract: A manufacturing method for manufacturing a pipe joint including a circular tube-shaped housing and an elastically deformable circular tube-shaped seal member provided at an inner peripheral side of the housing. The pipe joint manufacturing method includes a process of placing the seal member inside a mold in a state in which the seal member is fitted to an outer periphery of a retaining pin, and a process of causing a molten resin to flow into the mold so as to mold the housing in a state in which the seal member is cooled through the retaining pin.

Abstract: A fixing member-attached resin pipe manufacturing method including a process of placing a part of a resin pipe inside a mold for molding a fixing member, and a process of causing a molten resin to flow into the mold so as to mold the fixing member in a state in which the resin pipe is pressurized from an inside of the resin pipe by supplying a fluid into the resin pipe.

Abstract: A piping joint connects a resin tube to a connection pipe having a protrusion formed on an outer peripheral surface of a distal end portion of the connection pipe. The piping joint includes a housing press-fitted into the resin tube and an elastically extendable and contractible seal member into which the connection pipe is inserted such that sealing is performed between the connection pipe and the seal member. The housing has a first housing portion positioned in one end portion and having an outer peripheral surface side press-fitted into the resin tube and a second housing portion positioned in the other end portion. The seal member has a first seal portion inserted on an inner peripheral surface side of the second housing portion.

Abstract: A piping joint connects a resin tube to a connection pipe having a protrusion formed on an outer peripheral surface of a distal end portion of the connection pipe. The piping joint includes a housing press-fitted into the resin tube and an elastically extendable and contractible seal member into which the connection pipe is inserted such that sealing is performed between the connection pipe and the seal member. The housing has a first housing portion positioned in one end portion and having an outer peripheral surface side press-fitted into the resin tube and a second housing portion positioned in the other end portion. The seal member has a first seal portion inserted on an inner peripheral surface side of the second housing portion.

Abstract: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

Abstract: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, fungal genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. These genes encode proteins participating in fungal cell wall synthesis. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

Abstract: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.