Patents by Inventor Fumio Endo

Fumio Endo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11771678
    Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: October 3, 2023
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Shiro Matsumoto, Takumi Era, Fumio Endo
  • Publication number: 20210260020
    Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.
    Type: Application
    Filed: March 11, 2021
    Publication date: August 26, 2021
    Inventors: Shiro MATSUMOTO, Takumi ERA, Fumio ENDO
  • Publication number: 20200046676
    Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 13, 2020
    Inventors: Shiro MATSUMOTO, Takumi ERA, Fumio ENDO
  • Patent number: 10000739
    Abstract: The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 19, 2018
    Assignee: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
    Inventors: Shoen Kume, Fumio Endo, Nobuaki Shiraki, Yasuko Shiraki, Kazuhiko Kume
  • Publication number: 20130252335
    Abstract: The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.
    Type: Application
    Filed: October 20, 2011
    Publication date: September 26, 2013
    Inventors: Shoen Kume, Fumio Endo, Nobuaki Shiraki, Yasuko Shiraki, Kazuhiko Kume
  • Patent number: 7659121
    Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 9, 2010
    Assignee: Bios Research Institute, Inc.
    Inventors: Fumio Endo, Kenji Okumura, Kimitoshi Nakamura
  • Publication number: 20090068734
    Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.
    Type: Application
    Filed: September 18, 2007
    Publication date: March 12, 2009
    Inventors: Fumio Endo, Kenji Okumura, Kimitoshi Nakamura
  • Publication number: 20070154463
    Abstract: A stem cell which can be differentiated to a hepatic cell, a pancreas cell or to a salivary gland cell is disclosed. The stem cell according to the present invention is originated from salivary gland duct epithelium, which can be differentiated to an alpha-fetoprotein-positive cell, an albumin-positive cell, an amylase-positive cell, an insulin-positive cell and a glucagon-positive cell by culture in vitro. By transplanting the stem cells according to the present invention, organs such as liver can be regenerated.
    Type: Application
    Filed: March 5, 2007
    Publication date: July 5, 2007
    Inventors: Fumio Endo, Kenji Okumura, Kimitoshi Nakamura
  • Publication number: 20070054398
    Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.
    Type: Application
    Filed: February 20, 2004
    Publication date: March 8, 2007
    Applicants: BIOS RESEARCH INSTITUTE INC., Fumio ENDO
    Inventors: Fumio Endo, Kenji Okumura, Kimitoshi Nakamura
  • Patent number: 7138239
    Abstract: A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a reagent for testing for multiple organ failure in SIRS, which comprises a reagent for determination of cytochrome C in body fluid.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: November 21, 2006
    Assignee: Eisai Co., Ltd.
    Inventors: Fumio Endo, Naoto Adachi, Hiroyuki Nunoi, Keisuke Watanabe
  • Publication number: 20060183176
    Abstract: A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.
    Type: Application
    Filed: April 12, 2006
    Publication date: August 17, 2006
    Inventors: Fumio Endo, Naoto Adachi, Hiroyuki Nunoi, Keisuke Watanabe
  • Patent number: 7070924
    Abstract: A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: July 4, 2006
    Assignee: EISAI Co., Ltd.
    Inventors: Fumio Endo, Naoto Adachi, Hiroyuki Nunoi, Keisuke Watanabe
  • Publication number: 20050084964
    Abstract: A stem cell which can be differentiated to a hepatic cell, a pancreas cell or to a salivary gland cell is disclosed. The stem cell according to the present invention is originated from salivary gland duct epithelium, which can be differentiated to an alpha-fetoprotein-positive cell, an albumin-positive cell, an amylase-positive cell, an insulin-positive cell and a glucagon-positive cell by culture in vitro. By transplanting the stem cells according to the present invention, organs such as liver can be regenerated.
    Type: Application
    Filed: November 15, 2002
    Publication date: April 21, 2005
    Inventors: Fumio Endo, Kenji Okumura, Kimitoshi Nakamura
  • Publication number: 20040257922
    Abstract: A recording medium apparatus has a storage section for storing a plurality of recording media, an ejection slot for ejecting the recording media stored in the storage section to the outside of the apparatus, a designation section (an user operation section and a OSD) to designate recording media which is to be ejected through the ejection slot out of the plurality of recording media stored in the storage section, and a control section (a system controller) for consecutively executing ejection of the recording media designated through the designation section in sequence.
    Type: Application
    Filed: April 13, 2004
    Publication date: December 23, 2004
    Applicant: PIONEER CORPORATION
    Inventors: Hideo Watanabe, Fumio Endo, Koji Watanabe, Mitsutoshi Morimoto
  • Publication number: 20040202448
    Abstract: An information reproducing apparatus for reproducing at least one of specific reproduction information, which needs a releasing process in reproducing the specific reproduction information, and reproduction information other than the specific reproduction information from a recording medium on which the specific reproduction information and the reproduction information are recorded, the information reproducing device is provided with; a releasing device which performs the releasing process in response to a release command input from the outside during the reproduction of the reproduction information or before the reproduction of the reproduction information, after the recording medium is loaded on the information reproducing device; and a reproducing device which reproduces the specific reproduction information after the releasing process is performed.
    Type: Application
    Filed: April 7, 2004
    Publication date: October 14, 2004
    Applicant: PIONEER CORPORATION
    Inventors: Hideo Watanabe, Koji Watanabe, Mitsutoshi Morimoto, Fumio Endo
  • Publication number: 20030231858
    Abstract: A reproduction and display method for a reproduction and display apparatus having a display device that displays video information and are production device that reproduces a recording medium on which at least video information to be displayed on the display device is recorded. The method includes judging whether or not a recording medium loaded on the reproduction device is a recording medium on which video information is recorded, activating the display device that is not in an activated state, when it is judged that the recording medium is a recording medium on which video information is recorded, and displaying the video information recorded on the recording medium, on the activated display device.
    Type: Application
    Filed: May 7, 2003
    Publication date: December 18, 2003
    Applicant: PIONEER CORPORATION
    Inventors: Fumio Endo, Mitsutoshi Morimoto, Hideo Watanabe, Koji Watanabe
  • Publication number: 20020192712
    Abstract: A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a reagent for testing for multiple organ failure in SIRS, which comprises a reagent for determination of cytochrome C in body fluid.
    Type: Application
    Filed: May 6, 2002
    Publication date: December 19, 2002
    Inventors: Fumio Endo, Naoto Adachi, Hiroyuki Nunoi, Keisuke Watanabe
  • Patent number: 6388960
    Abstract: An audio disk/memory disk player. At the time of playing a disk, TOC information in a lead-in area will be read out first after loading of the disk is complete. The player determines whether the disk to be played is an audio disk (CD) or a memory disk (CD-ROM) based on identifying information in the TOC information. If the disk is the memory disk, the operation goes directly to a pause mode so that upon reception of a read command transition to the searching for a designated address is promptly executed to quickly read out the desired data. Only when the disk being played is the audio disk, the audio system is changed to the audio disk from another source, thus permitting a user to view a map while listening to the previous source. When playing for an area having a series of group information recorded is complete in special play mode, the mode is quickly changed to the pause mode in the case of the memory disk to wait for the read command, thus ensuring quick reading of designated map data.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: May 14, 2002
    Assignee: Pioneer Electronic Corporation
    Inventors: Kiyoshi Furukawa, Yoichi Yamazaki, Fumio Endo, Akira Hayama, Toshiyuki Kimura, Junichi Nishida, Hitoshi Sato, Kenji Kaneko
  • Patent number: 5633842
    Abstract: A disk selection control device for a multidisk player, in which disk content identifying information and TOC information of the disks are preliminarily stored correspondingly with each other, and the disk content identifying information and disk holding position information of the disks are stored correspondingly with each other according to the TOC information when it is read-out. By inputting the disk content identifying information, the disk holding position information corresponding to the input disk content identifying information can be obtained from the above correspondency therebetween to thereby select a desired disk.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: May 27, 1997
    Assignee: Pioneer Electronic Corporation
    Inventors: Junichi Nishida, Fumio Endo, Akira Hayama, Toshiyuki Kimura, Hitoshi Sato, Kiyoshi Furukawa, Kenji Kaneko
  • Patent number: 5428592
    Abstract: A decoder is provided for decoding a sub-code recorded in a predetermined area of each of a CD and a CD-ROM. The CD and CD-ROM are discriminated based on the decoded sub-code. When CD-ROM is discriminated, an output signal of a pickup is prevented from being reproduced.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: June 27, 1995
    Assignee: Pioneer Electronic Corporation
    Inventor: Fumio Endo