Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.

Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.

Abstract: [Object] To clarify the mechanism associated with neuropathy in methylmalonic acidemia and to develop a new therapeutic drug or the like for neuropathy in organic acidemia on the basis of this finding. [Solving Means] The inventors established technologies for the establishment of iPS cells derived from a methylmalonic acidemia patient and establishment of a stable maintenance and culturing method using peripheral blood lymphocytes of a methylmalonic acidemia patient, and for the differentiation of methylmalonic acidemia patient-derived iPS cells into nerve cells. The inventors made clear that neuropathy in organic acidemia can be treated and prevented by replenishing cAMP using a series of these experiment technologies. The drug of the invention treats or prevents neuropathy by increasing cAMP in organic acidemia.

Abstract: The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.

Abstract: The purpose of the present invention is to provide a method and a culture medium which are capable of efficiently inducing the differentiation of pluripotent stem cells such as ES cells and iPS cells into desired cells by a simple means. The differentiation of pluripotent stem cells can be induced by culturing mammal-derived pluripotent stem cells in a differentiation culture medium that does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine. Also provided is a differentiation-inducing culture medium which does not contain at least one amino acid selected from the group consisting of methionine, leucine, cysteine, tyrosine and arginine.

Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

Abstract: A stem cell which can be differentiated to a hepatic cell, a pancreas cell or to a salivary gland cell is disclosed. The stem cell according to the present invention is originated from salivary gland duct epithelium, which can be differentiated to an alpha-fetoprotein-positive cell, an albumin-positive cell, an amylase-positive cell, an insulin-positive cell and a glucagon-positive cell by culture in vitro. By transplanting the stem cells according to the present invention, organs such as liver can be regenerated.

Abstract: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and albumin-positive cell, (2) an insulin-positive cell and (3) a glucagon-positive cell by culture in vitro.

Abstract: A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a reagent for testing for multiple organ failure in SIRS, which comprises a reagent for determination of cytochrome C in body fluid.

Abstract: A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.

Abstract: A method for detecting cell death, which comprises determining cytochrome C in body fluid and detecting cell death based on a quantified value, as well as a method for determining cytochrome C in body fluid by a sandwich method and a reagent for measuring cytochrome C for determination cytochrome C in body fluid by a sandwich method, which comprises an antibody directed to cytochrome C as an ingredient.

Abstract: A stem cell which can be differentiated to a hepatic cell, a pancreas cell or to a salivary gland cell is disclosed. The stem cell according to the present invention is originated from salivary gland duct epithelium, which can be differentiated to an alpha-fetoprotein-positive cell, an albumin-positive cell, an amylase-positive cell, an insulin-positive cell and a glucagon-positive cell by culture in vitro. By transplanting the stem cells according to the present invention, organs such as liver can be regenerated.

Abstract: A recording medium apparatus has a storage section for storing a plurality of recording media, an ejection slot for ejecting the recording media stored in the storage section to the outside of the apparatus, a designation section (an user operation section and a OSD) to designate recording media which is to be ejected through the ejection slot out of the plurality of recording media stored in the storage section, and a control section (a system controller) for consecutively executing ejection of the recording media designated through the designation section in sequence.

Abstract: An information reproducing apparatus for reproducing at least one of specific reproduction information, which needs a releasing process in reproducing the specific reproduction information, and reproduction information other than the specific reproduction information from a recording medium on which the specific reproduction information and the reproduction information are recorded, the information reproducing device is provided with; a releasing device which performs the releasing process in response to a release command input from the outside during the reproduction of the reproduction information or before the reproduction of the reproduction information, after the recording medium is loaded on the information reproducing device; and a reproducing device which reproduces the specific reproduction information after the releasing process is performed.

Abstract: A reproduction and display method for a reproduction and display apparatus having a display device that displays video information and are production device that reproduces a recording medium on which at least video information to be displayed on the display device is recorded. The method includes judging whether or not a recording medium loaded on the reproduction device is a recording medium on which video information is recorded, activating the display device that is not in an activated state, when it is judged that the recording medium is a recording medium on which video information is recorded, and displaying the video information recorded on the recording medium, on the activated display device.

Abstract: A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a reagent for testing for multiple organ failure in SIRS, which comprises a reagent for determination of cytochrome C in body fluid.

Abstract: An audio disk/memory disk player. At the time of playing a disk, TOC information in a lead-in area will be read out first after loading of the disk is complete. The player determines whether the disk to be played is an audio disk (CD) or a memory disk (CD-ROM) based on identifying information in the TOC information. If the disk is the memory disk, the operation goes directly to a pause mode so that upon reception of a read command transition to the searching for a designated address is promptly executed to quickly read out the desired data. Only when the disk being played is the audio disk, the audio system is changed to the audio disk from another source, thus permitting a user to view a map while listening to the previous source. When playing for an area having a series of group information recorded is complete in special play mode, the mode is quickly changed to the pause mode in the case of the memory disk to wait for the read command, thus ensuring quick reading of designated map data.

Abstract: A disk selection control device for a multidisk player, in which disk content identifying information and TOC information of the disks are preliminarily stored correspondingly with each other, and the disk content identifying information and disk holding position information of the disks are stored correspondingly with each other according to the TOC information when it is read-out. By inputting the disk content identifying information, the disk holding position information corresponding to the input disk content identifying information can be obtained from the above correspondency therebetween to thereby select a desired disk.

Abstract: A decoder is provided for decoding a sub-code recorded in a predetermined area of each of a CD and a CD-ROM. The CD and CD-ROM are discriminated based on the decoded sub-code. When CD-ROM is discriminated, an output signal of a pickup is prevented from being reproduced.