Patents by Inventor Fumio Nomura

Fumio Nomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11193948
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: December 7, 2021
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Patent number: 10761102
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 1, 2020
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180136240
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Application
    Filed: November 15, 2017
    Publication date: May 17, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180088137
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 29, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20160370382
    Abstract: An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma.
    Type: Application
    Filed: July 22, 2016
    Publication date: December 22, 2016
    Applicant: NITTO BOSEKI CO., LTD.
    Inventors: Ryo KOJIMA, Kenta NODA, Masanori SEIMIYA, Kazuyuki SOGAWA, Fumio NOMURA
  • Patent number: 9017959
    Abstract: Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the ?-E chain and ? chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing antibodies that recognize the N terminal of said peptide marker and antibodies that recognize the C terminal of said peptide marker into contact with said peptide marker, forming immune complexes of said peptide marker and the two antibodies, and immunoassaying the obtained immune complexes.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: April 28, 2015
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Wataru Kikuchi, Momoe Sato, Kenta Noda, Iwao Kiyokawa, Toshihide Miura, Ryo Kojima, Fumio Nomura, Kazuyuki Sogawa
  • Patent number: 8563235
    Abstract: A method of detecting an abnormal amount of a biomarker associated with biliary tract cancer in a subject can comprise: a) quantitating an amount of a fragment of prothrombin having an m/z value of about 4204 m/z in a biological sample from the subject; and b) comparing the quantitated value obtained in (a) with a threshold value.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: October 22, 2013
    Assignee: National University Corporation Chiba University
    Inventors: Shintaro Kikkawa, Kazuyuki Sogawa, Osamu Yokosuka, Fumio Nomura
  • Publication number: 20130089871
    Abstract: The detection of a non-alcoholic steatohepatitis patient and the accurate discrimination between a normal person and a non-alcoholic steatohepatitis patient can be achieved by measuring alanine-glyoxylate amino transferase in a sample.
    Type: Application
    Filed: June 13, 2011
    Publication date: April 11, 2013
    Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NITTOBO MEDICAL CO., LTD., NITTO BOSEKI CO., LTD.
    Inventors: Fumio Nomura, Motoi Nishimura, Katsuhiro Katayama, Iwao Kiyokawa
  • Publication number: 20120309034
    Abstract: A reaginic antibody of Ku86 and a substance capable of binding with the autoantibody of Ku86 are acted on a complex of Ku86 and the autoantibody thereof in a subject. Said complex can be measured by measuring the obtained immune complex of the aforementioned complex, reaginic antibody, and substance capable of binding with the autoantibody of Ku86. As a consequence, it is possible to determine whether the cancer is a primary hepatoma, colon cancer, stomach cancer, pancreatic cancer, breast cancer, lung cancer, or an esophageal cancer.
    Type: Application
    Filed: February 7, 2011
    Publication date: December 6, 2012
    Applicant: NITTO BOSEKI CO., LTD.
    Inventors: Ryo Kojima, Kenta Noda, Masanori Seimiya, Kazuyuki Sogawa, Fumio Nomura
  • Publication number: 20120282638
    Abstract: An autoantibody against Ku86 can be measured by reacting the autoantibody contained in a sample with a Ku86 antigen (which serves as a reagent) to produce an immune complex of the autoantibody and the Ku86 antigen and measuring the immune complex using a labeled anti-human immunoglobulin antibody. The measurement of the autoantibody enables the determination of primary hepatocellular carcinoma.
    Type: Application
    Filed: January 18, 2011
    Publication date: November 8, 2012
    Inventors: Ryo Kojima, Kenta Noda, Masanori Seimiya, Kazuyuki Sogawa, Fumio Nomura
  • Publication number: 20120276562
    Abstract: Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the ?-E chain and ? chain of human fibrinogens and which is used as a peptide marker for diagnosing hepatic disease can be specifically assayed in a biological sample containing contaminating peptides by bringing antibodies that recognize the N terminal of said peptide marker and antibodies that recognize the C terminal of said peptide marker into contact with said peptide marker, forming immune complexes of said peptide marker and the two antibodies, and immunoassaying the obtained immune complexes.
    Type: Application
    Filed: October 13, 2010
    Publication date: November 1, 2012
    Applicant: Nitto Boseki Co., Ltd.
    Inventors: Wataru Kikuchi, Momoe Sato, Kenta Noda, Iwao Kiyokawa, Toshihide Miura, Ryo Kojima, Fumio Nomura, Kazuyuki Sogawa
  • Patent number: 7998693
    Abstract: The present invention provides a new additional identification of a gene related to cancer expression and a diagnostic kit using the same.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: August 16, 2011
    Assignee: National University Corporation Chiba University
    Inventors: Hideaki Shimada, Takeshi Tomonaga, Kazuyuki Matsushita, Takenori Ochiai, Fumio Nomura
  • Patent number: 7974669
    Abstract: The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavenumber range of 1020-1040 cm?1, and by integrating the intensity of absorption of the wavenumber range of 1020-1040 cm?1 within the absorption spectrum. Alternatively, a glucose concentration in blood is measured based on an integrated value through measuring an absorption spectrum including the wavenumber range of 1010-1050 cm31 1; obtaining a second-derivative spectrum by calculating a second derivative of the absorption spectrum that includes the wavenumber range of 1010-1050 cm?1 in the absorption spectrum; determining an integration range based on the second derivative spectrum; and then obtaining the integrated value by integrating the intensity of absorption based on this determined integration range.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: July 5, 2011
    Assignee: National University Corporation Chiba University
    Inventors: Akihide Kitamura, Fumio Nomura, Takashi Karatsu
  • Publication number: 20110108722
    Abstract: A method of detecting an abnormal amount of a biomarker associated with biliary tract cancer in a subject can comprise: a) quantitating an amount of a fragment of prothrombin having an m/z value of about 4204 m/z in a biological sample from the subject; and b) comparing the quantitated value obtained in (a) with a threshold value.
    Type: Application
    Filed: November 2, 2010
    Publication date: May 12, 2011
    Inventors: Shintaro Kikkawa, Kazuyuki Sogawa, Osamu Yokosuka, Fumio Nomura
  • Patent number: 7897562
    Abstract: An object of the present invention is to provide a novel means for stably and surely inducing cell apoptosis using the c-myc gene as a target. The present invention relates to an apoptosis-inducing agent containing a protein that interacts with an FBP protein or a polynucleotide encoding the protein as an active ingredient and a method for inducing apoptosis, which comprises a step of causing the apoptosis-inducing agent to come into contact with cells.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: March 1, 2011
    Assignee: National University Corporation Chiba University
    Inventors: Hideaki Shimada, Kazuyuki Matsushita, Takeshi Tomonaga, Fumio Nomura, Takenori Ochiai
  • Publication number: 20100330554
    Abstract: The present invention provides novel solid cancer antigenic proteins, and diagnostic kits for solid cancer and therapeutic agents for solid cancer based on the antigenic proteins. Specifically, the present invention provides a human solid cancer antigenic polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 48, 50, 52, 54, 56, 59, 61, 63, 65, 67, 69, 71, 73, and 75.
    Type: Application
    Filed: May 18, 2009
    Publication date: December 30, 2010
    Applicants: MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., HIDEAKI SHIMADA
    Inventors: HIDEKI SHIMADA, TAKESHI TOMONAGA, TAKAKI HIWASA, KAZUYUKI MATSUSHITA, TAKENORI OCHIAI, FUMIO NOMURA, MASAKI TAKIGUCHI
  • Patent number: 7781180
    Abstract: Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen ?-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, and a protein which is an apolipoprotein AI decomposition product and has a molecular weight of 28,000, each showing an increase or a decrease with the habit of drinking, are newly found out. By detecting or quantifying these proteins, a liver disease in a subject such as one having a problem of drinking can be diagnosed at the early stage.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: August 24, 2010
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Fumio Nomura, Kazuyuki Sogawa, Takeshi Tomonaga, Takenori Ochiai, Hideaki Shimada, Tatsuya Ohashi, Katsuhiro Katayama
  • Publication number: 20100196928
    Abstract: The present invention provides a new additional identification of a gene related to cancer expression and a diagnostic kit using the same.
    Type: Application
    Filed: January 5, 2006
    Publication date: August 5, 2010
    Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideaki Shimada, Takeshi Tomonaga, Kazuyuki Matsushita, Takenori Ochiai, Fumio Nomura
  • Publication number: 20090275059
    Abstract: Using the protein chip technology, biological samples such as sera are subjected to proteome analysis. Thus, a protein which is a human fibrinogen ?-E chain decomposition product and has a molecular weight of 5,900, a protein which is an apolipoprotein AII decomposition product and has a molecular weight of 7,800, and a protein which is an apolipoprotein AI decomposition product and has a molecular weight of 28,000, each showing an increase or a decrease with the habit of drinking, are newly found out. By detecting or quantifying these proteins, a liver disease in a subject such as one having a problem of drinking can be diagnosed at the early stage.
    Type: Application
    Filed: March 4, 2009
    Publication date: November 5, 2009
    Applicant: NITTO BOSEKI CO., LTD.
    Inventors: Fumio Nomura, Kazuyuki Sogawa, Takeshi Tomonaga, Takenori Ochiai, Hideaki Shimada, Tatsuya Ohashi, Katsuhiro Katayama
  • Patent number: 7611855
    Abstract: Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the competitive substance than for the target substance, a specimen is treated with these two antibodies. Then, the competitive substance in the specimen first binds to the second antibody and thus the ratio of the target substance to the competitive substance in the specimen is enlarged. As a result, the target substance becomes liable to bind to the first antibody and, in its turn, the reactivity of the target substance is elevated compared with the case of using the first antibody alone. Thus, the target substance in the specimen can be accurately assayed while avoiding the effects of the competitive substance contained in the specimen.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: November 3, 2009
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Tatsuya Ohashi, Toshihide Miura, Yoshihiko Igarashi, Fumio Nomura, Takeshi Tomonaga, Katsuhiro Katayama