Patents by Inventor Fumio Sugawara
Fumio Sugawara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932555Abstract: A water treatment management apparatus used for monitoring and evaluating water supplied to a water treatment system such as an ultrapure water production system and performing appropriate management of operation of the water treatment system includes: a pure water production unit for evaluation to which water to be supplied to the water treatment system is supplied as target water, the pure water production unit for evaluation including a TOC removal apparatus for performing a unit operation of removing total organic carbon (TOC) components; and measuring means for measuring TOC concentration at a plurality of measurement points in the pure water production unit for evaluation, the plurality of the measurement points including an inlet and an outlet of the pure water production unit for evaluation.Type: GrantFiled: February 14, 2019Date of Patent: March 19, 2024Assignee: ORGANO CORPORATIONInventors: Nozomi Takatori, Hiroshi Sugawara, Kazushige Takahashi, Fumio Sudo
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Porphyrin compound or salt thereof, cancer therapeutic agent, photosensitizer, and fluorescent probe
Patent number: 11643430Abstract: There is provided with a porphyrin compound represented by Formula (I) or a salt thereof; where A is a linking group represented as —X—NHCO— where X is a C1 to C6 alkylene group, each of R1, R2, R4, R5, R7, R8, R10, and R11 is a hydrogen atom, each of R3, R6, and R9 is a substituent of Formula; R12 is selected from a group of substituents represented by Formulae, R13 is a sulfo group, Ra, Rb, and Rc are substituents independently selected from C1 to C6 alkyl groups, and Rd is a hydrogen atom or a C1 to C6 alkyl group, and Rx is a substituent represented by General Formula. The porphyrin compound is useful as a cancer therapeutic agent, photosensitizer and fluorescent probe.Type: GrantFiled: August 31, 2021Date of Patent: May 9, 2023Assignees: M.T.3, INC., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITYInventors: Hiroaki Horiuchi, Masahiko Oshige, Ichiro Matsuo, Tetsuo Okutsu, Shinji Katsura, Toshitada Yoshihara, Seiji Tobita, Fumio Sugawara, Kengo Sakaguchi -
Publication number: 20220098227Abstract: There is provided with a compound. The compound is represented by formula or a salt thereof. R1 is an aliphatic hydrocarbon group having 10 to 26 carbon atoms.Type: ApplicationFiled: September 2, 2021Publication date: March 31, 2022Applicants: M.T.3, Inc., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITYInventors: Masahiko OSHIGE, Ichiro MATSUO, Hiroaki HORIUCHI, Shinji KATSURA, Fumio SUGAWARA, Kengo SAKAGUCHI
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Patent number: 11267840Abstract: There is provided with a compound. The compound is represented by formula or a salt thereof. R1 is an aliphatic hydrocarbon group having 10 to 26 carbon atoms.Type: GrantFiled: September 2, 2021Date of Patent: March 8, 2022Assignees: M.T.3, INC., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITYInventors: Masahiko Oshige, Ichiro Matsuo, Hiroaki Horiuchi, Shinji Katsura, Fumio Sugawara, Kengo Sakaguchi
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Publication number: 20220064203Abstract: There is provided with a compound represented by Formula or a salt thereof; where A is a linking group represented as —X—NHCO— where X is a C1 to C6 alkylene group, each of R1, R2, R4, R5, R7, R8, R10, and R11 is a hydrogen atom, each of R3, R6, and R9 is a substituent of Formula; R12 is selected from a group of substituents represented by Formulae, R13 is a sulfo group, Ra, Rb, and Rc are substituents independently selected from C1 to C6 alkyl groups, and Rd is a hydrogen atom or a C1 to C6 alkyl group, and Rx is a substituent represented by General Formula.Type: ApplicationFiled: August 31, 2021Publication date: March 3, 2022Applicants: M.T.3, Inc., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITYInventors: Hiroaki HORIUCHI, Masahiko OSHIGE, Ichiro MATSUO, Tetsuo OKUTSU, Shinji KATSURA, Toshitada YOSHIHARA, Seiji TOBITA, Fumio SUGAWARA, Kengo SAKAGUCHI
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Patent number: 7973145Abstract: Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.Type: GrantFiled: January 29, 2009Date of Patent: July 5, 2011Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Keisuke Ohta, Masahiko Miura, Kengo Sakaguchi, Fumio Sugawara, Noriyuki Sato, Hiroeki Sahara, Nobuaki Takahashi, Yoko Mori, Takayuki Yamazaki, Kazuyoshi Masaki, Hiroshi Murata
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Publication number: 20110158908Abstract: Disclosed are: a composition and a method for the diagnosis and/or the treatment of a CSABP-related disease, the regulation of the proliferation of an RNA virus and the regulation of an RNA-metabolizing system, which targets a cyclosporin A-binding protein (CSABP); a method for the screening of a component that targets a CSABP; a composition and a method for the detection/inhibition of CsA, NS5B or cyclosphilin B by utilizing a CSABP; a promoter for a CSABP; a method for the screening of a substance capable of regulating the expression of a CSABP by utilizing the promoter; and a method for the determination of the occurrence or clinical stage of a CSABP-related disease.Type: ApplicationFiled: August 22, 2008Publication date: June 30, 2011Applicant: Sapporo Medical UniversityInventors: Hiroeki Sahara, Yoko Mori, Nobuaki Takahashi, Noriyuki Sato, Fumio Sugawara, Kengo Sakaguchi, Kengo Morohashi, Kazuki Iwabata, Koichi Watashi, Kunitada Shimotohno, Kokichi Kikuchi, Wataru Tsutae, Hiroki Miyashita
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Publication number: 20100298246Abstract: Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Applicant: TOYO SUISAN KAISHA, LTD.Inventors: Keisuke Ohta, Masahiko Miura, Kengo Sakaguchi, Fumio Sugawara, Noriyuki Sato, Hiroeki Sahara, Nobuaki Takahashi, Yoko Mori, Takayuki Yamazaki, Kazuyoshi Masaki, Hiroshi Murata
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Publication number: 20100202971Abstract: The problem to be solved of the present invention is to provide a novel compound which specifically resides in a tumor, a method for allowing it to reside in a tumor, and a method for detecting, diagnosing, and treating tumor with use thereof. Means for solving the problem is a compound represented by chemical formula (I) wherein R is an anionic group binding to hydrogen, R1 is OH, OCOH, OCO(CH2)hCH3, or an acting group, h being an integer of 0 or more, R2 is H, OH, OCOH, OCO(CH2)iCH3, or an acting group, i being an integer of 0 or more, R3 is OH, SO3H, or an acting group, R4 is OH, SO3H, or an acting group, and R5 is OH, SO3H, or an acting group, at least one of R1, R2, R3, R4, and R5 containing an acting group, or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: January 15, 2010Publication date: August 12, 2010Inventors: Keisuke OHTA, Masahiko Miura, Kengo Sakaguchi, Fumio Sugawara, Masahiro Ishima, Hiroshi Murata
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Publication number: 20090253644Abstract: A radiosensitizer comprising, as an active ingredient, at least one kind of compound selected from the group consisting of a compound represented by the following general formula (1): (wherein R101 represents an acyl residue of higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of higher fatty acid), and a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 8, 2009Publication date: October 8, 2009Applicant: TOYO SUISAN KAISHA, LTD.Inventors: Ippei Sakimoto, Masahiko Miura, Keiko Kataoka, Kengo Sakaguchi, Fumio Sugawara, Keisuke Ohta, Takayuki Yamazaki
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Publication number: 20090209475Abstract: Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and pharmaceutically acceptable salts thereof are effective for treating tumors.Type: ApplicationFiled: January 29, 2009Publication date: August 20, 2009Applicant: TOYO SUISAN KAISHA, LTD.Inventors: Keisuke Ohta, Masahiko Miura, Kengo Sakaguchi, Fumio Sugawara, Noriyuki Sato, Hiroeki Sahara, Nobuaki Takahashi, Yoko Mori, Takayuki Yamazaki, Kazuyoshi Masaki, Hiroshi Murata
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Patent number: 7378398Abstract: A method for treating an adenocarcinoma excluding colon cancer, lung cancer and gastric cancer, comprising administering to a subject in need thereof and suffering from adenocarcinoma cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein R101 represents an acyl residue of an unsaturated higher fatty acid, and R102 represents a hydrogen atom, and/or at least one pharmaceutically acceptable salt thereof.Type: GrantFiled: July 3, 2006Date of Patent: May 27, 2008Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kazuyoshi Masaki, Kotaro Nakayama, Kengo Sakaguchi, Noriyuki Sato, Hiroeki Sahara, Tatsuya Fujita
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Publication number: 20070219145Abstract: A radiosensitizer comprising, as an active ingredient, at least one kind of compound selected from the group consisting of a compound represented by the following general formula (1): (wherein R101 represents an acyl residue of higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of higher fatty acid), and a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 24, 2005Publication date: September 20, 2007Inventors: Ippei Sakimoto, Masahiko Miura, Keiko Kataoka, Kengo Sakaguchi, Fumio Sugawara, Keisuke Ohta, Takayuki Yamazaki
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Patent number: 7268209Abstract: Peptides having, as constitutive amino acids, (1) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; (2) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 3 valine residues, and 5 leucine residues, and having a 3-hydroxydecanoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof; or (3) 4 glutamine residues, 1 glutamic acid residue, 1 serine residue, 2 valine residues, 1 isoleucine residue and 5 leucine residues, and having a 3-hydroxydodec-5-enoyl group bonded, via an amide linkage, to the N-terminal leucine residue thereof. The peptides have an antiviral activity. A strain capable of producing the above peptides and belonging to a new species of genus Pseudomonas.Type: GrantFiled: July 31, 2003Date of Patent: September 11, 2007Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Masahiro Ishima, Tsutomu Yoshida, Takayuki Yamazaki, Fumio Sugawara, Kiyoshige Hatta, Manabu Shimojoe, Kazuyoshi Masaki
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Patent number: 7148200Abstract: A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding colon cancer, lung cancer and gastric cancer. The method comprises administering to a subject in need thereof and suffering from cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein R101 represents an acyl residue of an unsaturated fatty acid and R102 represents a hydrogen atom and/or at least one pharmaceutically acceptable salt thereof.Type: GrantFiled: October 2, 2003Date of Patent: December 12, 2006Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kazuyoshi Masaki, Kotaro Nakayama, Kengo Sakaguchi, Noriyuki Sato, Hiroeki Sahara, Tatsuya Fujita
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Publication number: 20060252703Abstract: A method for treating an adenocarcinoma excluding colon cancer, lung cancer and gastric cancer, comprising administering to a subject in need thereof and suffering from adenocarcinoma cancer, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol compound represented by formula (1): wherein R101 represents an acyl residue of an unsaturated higher fatty acid, and R102 represents a hydrogen atom, and/or at least one pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 3, 2006Publication date: November 9, 2006Applicant: TOYO SUISAN KAISHA, LTD.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kazuyoshi Masaki, Kotaro Nakayama, Kengo Sakaguchi, Noriyuki Sato, Hiroeki Sahara, Tatsuya Fujita
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Patent number: 6919316Abstract: An immunosuppressive agent comprising, as an effective ingredient, at least one compound selected from the group consisting of compounds represented by general formula (1) below and pharmaceutically acceptable salts thereof: wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or acyl residue of a higher fatty acid.Type: GrantFiled: December 23, 2003Date of Patent: July 19, 2005Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kengo Sakaguchi, Noriko Asano, Mika Takenouchi, Kazuyoshi Masaki, Noriyuki Sato, Tatsuya Fujita, Hiroeki Sahara
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Patent number: 6770629Abstract: A medicament containing at least one compound selected from the group consisting of compounds represented by General formula (1): wherein R101 represents an acyl residue of an unsaturated higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of an unsaturated higher fatty acid, and pharmaceutically acceptable salts thereof, as an active ingredient.Type: GrantFiled: August 22, 2001Date of Patent: August 3, 2004Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kazuyoshi Masaki, Kotaro Nakayama, Kengo Sakaguchi, Noriyuki Sato, Hiroeki Sahara, Tatsuya Fujita
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Publication number: 20040142881Abstract: An immunosuppressive agent comprising, as an effective ingredient, at least one compound selected from the group consisting of compounds represented by general formula (1) below and pharmaceutically acceptable salts thereof: 1Type: ApplicationFiled: December 23, 2003Publication date: July 22, 2004Applicant: TOYO SUISAN KAISHA, LTD.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kengo Sakaguchi, Noriko Asano, Mika Takenouchi, Kazuyoshi Masaki, Noriyuki Sato, Tatsuya Fujita, Hiroeki Sahara
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Patent number: 6759522Abstract: Novel sulforhamnosylacylglycerol derivatives represented by General Formula (1): where R101 represents an acyl residue of a higher fatty acid and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid. The derivatives represented by General formula (1) are useful as, a DNA polymerase inhibitor and an anticancer agent.Type: GrantFiled: August 24, 2001Date of Patent: July 6, 2004Assignee: Toyo Suisan Kaisha, Ltd.Inventors: Takayuki Yamazaki, Fumio Sugawara, Keisuke Ohta, Kazuyoshi Masaki, Kotaro Nakayama, Kengo Sakaguchi, Noriyuki Sato, Hiroeki Sahara, Tatsuya Fujita