Abstract: [Problem] To provide the following: an agent for treating cancer, particularly an agent for inhibiting cancer cell proliferation or an agent for inhibiting or preventing cancer metastasis; drug that uses the agent; a method for assessing the effect of cancer treatment; a method for estimating the prognosis of cancer treatment; a method for screening for a substance having a cancer proliferation-inhibiting effect; and a method for screening a substance having a cancer metastasis-impeding effect. [Solution] Provided is a drug containing a nucleic acid formed from a nucleotide sequence having sequence identity of 70% or greater with at least sequence No. 1 or No. 2, wherein the nucleic acid shows protein expression-inhibiting activity.

Abstract: [Problem] To provide the following: an agent for treating cancer, particularly an agent for inhibiting cancer cell proliferation or an agent for inhibiting or preventing cancer metastasis; drug that uses the agent; a method for assessing the effect of cancer treatment; a method for estimating the prognosis of cancer treatment; a method for screening for a substance having a cancer proliferation-inhibiting effect; and a method for screening a substance having a cancer metastasis-impeding effect. [Solution] Provided is a drug containing a nucleic acid formed from a nucleotide sequence having sequence identity of 70% or greater with at least sequence No. 1 or No. 2, wherein the nucleic acid shows protein expression-inhibiting activity.

Abstract: The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-16, using miR-16 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.

Abstract: An endoscope used for observing the interior of a cavity in a human body. In the endoscope according to the present invention, an image sensor is provided in the forward end of an insertion section and an object of interest is displayed on a screen of a television set in response to a video signal obtained from the image sensor. According to the present invention, image information from the image sensor is provisionally stored in a memory, and the read-out from the memory is performed by horizontal scanning in accordance with read-out information by reversing the steps in the case of the write-in. With this arrangement, an image of the object of interest, which is inverted in an optical system in the forward end of the insertion section of the endoscope, can be displayed on the screen of the television as a normal image.

Abstract: An endoscope of the type having in its imaging system a solid state imaging device provided in its insertable section into a cavity of a living body for receiving an optical image and converting it into electrical signals which are processed and then transmitted to a monitor to be visualized thereon. The endoscope comprises an operating part having an insertable section into a cavity which includes therein a solid state imaging device for receiving an optical image and converting it into electrical signals, a control unit for providing driving signals for the solid state imaging device and processing the signals from the solid state imaging device to provide a video signal and a display for receiving the video signal from the control unit to be visualized as, for example, a television picture. The operating part further includes an adjusting means for modifying levels of the driving signals corresponding to the characteristics of the solid state imaging device.

Abstract: An endoscope used for observing the interior of a cavity and the like of a living human body. The endoscope according to the present invention is of such an arrangement that an image sensor is provided in the forward end of an insertion section and an object of interest can be displayed on a screen of a television set in response to a video signal obtained from the image sensor. According to the present invention, a control unit is provided therein with a circuit for producing an image standstill command and a shutter release command depending on a time or times of operation, or a step or steps in press-in value of a single push in switch provided a control section of the endoscope, so that the provision of a single control button makes it possible to make a monitored image stand still and to release a shutter of a camera.

Abstract: An endoscope includes in the viewing head of its insertable section into a cavity of a living body an image sensor for generating a video signal which in turn is transmitted to a television display to be visualized thereon as a television picture. The image sensor with a shape such as a plate is located in a plane containing the longitudinal center line of the viewing head. The location permits to keep the shape of the viewing head unchanged. In addition, the image sensor thus located the interior of the viewing head into two spaces, one accommodating therein a forceps channel, and the other accommodating therein an objective lens assembly, resulting in a most efficient arrangement of essential elements for endoscope.