Patents by Inventor Fumiya Ikarashi

Fumiya Ikarashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline methyl (4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate
    Patent number: 10125146
    Abstract: A crystalline methyl (4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b][1,3]oxazine-9-carboxylate of the formula (U2):
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: November 13, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Yukihito Sumino, Moriyasu Masui, Daisuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • Crystalline methyl (4R,12aS)-7-(benzyloxy)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylate
    Patent number: 10125147
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: November 13, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Yukihito Sumino, Moriyasu Masui, Daisuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • Crystalline dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
    Patent number: 10000508
    Abstract: A crystalline dimethyl 2-(benzyloxy)-1-(2,2-diethoxy-ethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate of the formula (U1):
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: June 19, 2018
    Assignee: Shionogi & Co., Ltd
    Inventors: Yukihito Sumino, Moriyasu Masui, Daisuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • Method of producing (3S,11aR)-6,8-dihalo-3-methyl-2,3,11,11a-tetrahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-5,7-diones
    Patent number: 9969750
    Abstract: A process for preparing a compound shown by formula (W6): wherein each Hal is independently chloro or bromo, using a novel process for preparing a pyridine derivative represented by formula (W2), wherein R6d is as defined herein.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: May 15, 2018
    Assignee: Shionogi and Co., Ltd.
    Inventors: Yukihito Sumino, Moriyasu Masui, Daisuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • Process for producing alkynylketone derivative
    Patent number: 9951051
    Abstract: The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 24, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Genta Tadano, Fumiya Ikarashi, Kazuya Okamoto, Toshikatsu Maki, Motoyuki Hagihara
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20180044351
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein IV is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: September 20, 2017
    Publication date: February 15, 2018
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Daisuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20180037593
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: September 20, 2017
    Publication date: February 8, 2018
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Daisuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20180037592
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: September 20, 2017
    Publication date: February 8, 2018
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Daisuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20180037591
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein RX is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: September 20, 2017
    Publication date: February 8, 2018
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Daisuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • Method of producing (4R,12aS)-7,9-dihalo-4-methyl-3,4,12,12a-tetrahydro-2H-pyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazine-6,8-diones
    Patent number: 9802959
    Abstract: A process for preparing a compound shown by formula (W5): wherein each Hal is independently chloro or bromo, using a novel process for preparing a pyridine derivative represented by formula (W2), wherein R6d is as defined herein.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: October 31, 2017
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yukihito Sumino, Moriyasu Masui, Diasuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20170240564
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: March 28, 2017
    Publication date: August 24, 2017
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Daisuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE
    Publication number: 20170197943
    Abstract: The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 13, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Genta TADANO, Fumiya IKARASHI, Kazuya OKAMOTO, Toshikatsu MAKI, Motoyuki HAGIHARA
  • Methods of producing substituted (3S,11aR)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-Hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamides
    Patent number: 9650394
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) wherein R1d, R2d, and R4d are as defined herein.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: May 16, 2017
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yukihito Sumino, Moriyasu Masui, Daisuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • METHODS OF PRODUCING COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY
    Publication number: 20160229870
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) wherein RX is an optionally substituted carbocyclyl lower alkyl, or the like or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) wherein R1d, R2d, and R4 are as defined herein.
    Type: Application
    Filed: March 17, 2016
    Publication date: August 11, 2016
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Diasuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • Methods of producing substituted (4R,12AS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1?,2?:4,5]pyrazino[2,1-B][1,3]oxazine-9-carboxamides
    Patent number: 9321789
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) wherein R1d, R2d, and R4d are as defined herein.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: April 26, 2016
    Assignee: Shinogi & Co., Ltd.
    Inventors: Yukihito Sumino, Moriyasu Masui, Diasuke Yamada, Fumiya Ikarashi, Kazuya Okamoto
  • Method of producing compounds having HIV integrase inhivitory activity
    Publication number: 20150038702
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) wherein R1d, R2d, and R4d are as defined herein.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Inventors: Yukihito SUMINO, Moriyasu MASUI, Diasuke YAMADA, Fumiya IKARASHI, Kazuya OKAMOTO
  • Process for Preparing Compound Having HIV Integrase Inhibitory Activity
    Publication number: 20140011995
    Abstract: A process for preparing a compound represented by formula (Y1) or (Y2) [wherein Rx is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R1d is hydrogen, halogen, or the like; R2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R4d is a lower alkyl optionally substituted with substituent E, or the like; and R6d is a lower alkyl group optionally substituted with substituent group E, or the like].
    Type: Application
    Filed: August 4, 2011
    Publication date: January 9, 2014
    Inventors: Yukihito Sumino, Moriyasu Masui, Diasuke Yamada, Fumiya Ikarashi, Kazuya Okamoto