Abstract: There are provided an adsorbent which can effectively adsorb and remove endogenous cannabinoid in fluid, and a process for removing endogenous cannabinoid in fluid by means of the adsorbent. The adsorbent of endogenous cannabinoid is obtained by fixing a compound having a log P value (P indicating distribution coefficient in octanol-water system) of at least 3.50 on a water-insoluble carrier. Endogenous cannabinoid in fluid can be adsorbed and removed in an effective manner by contacting the adsorbent of endogenous cannabinoid with fluid containing endogenous cannabinoid.

Abstract: An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.

Abstract: An adsorbent suitable for adsorption of a transforming growth factor-&bgr; (TGF-&bgr;) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier. TGF-&bgr; present in a body fluid can be efficiently removed by bringing the body fluid into contact with the adsorbent.

Abstract: An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.

Abstract: The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.

Abstract: An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely.

Abstract: The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.

Abstract: An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.