Patent number: 5523317
Abstract: Disclosed is a method of reducing blood pressure which comprises administering to a patient an imidazole derivative of the formula: ##STR1## wherein: each of R.sup.1 and R.sup.2 is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R.sup.1 and R.sup.2 are combined to form hetero ring; each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R.sup.3 is combined with R.sup.2 to form heteroring; R.sup.7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R.sup.8 and R.sup.9 is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R.sup.8 and R.sup.9 are combined to from alkylene; and n is 0 or 1.
Type:
Grant
Filed:
January 26, 1994
Date of Patent:
June 4, 1996
Assignee:
Nippon Chemiphar Co., Ltd.
Inventors:
Mitsuo Masaki, Fumiyo Hara, Toshiro Kamishiro