Patents by Inventor Funien TSAI

Funien TSAI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRUG SCREENING METHODS
    Publication number: 20240124871
    Abstract: Provided herein are systems and methods for drug screening single cells from a sample. A method for drug screening may comprise treating various single cell samples with different drugs or drug combinations, labeling of treated cells with a labeling agent comprising a sample barcode, and processing the treated, labeled cells to generate nucleic acid libraries for sequencing. One or more processes of the methods described herein may be performed within a partition, such as a droplet or well.
    Type: Application
    Filed: August 22, 2023
    Publication date: April 18, 2024
    Inventors: Dagmar Walter, FuNien Tsai, Kristen Nguyen Pham
  • METHODS AND COMPOSITIONS FOR STUDYING CELL EVOLUTION
    Publication number: 20230083163
    Abstract: The subject matter disclosed herein is generally directed to methods and compositions for tagging cells of interest, tracking evolution of the tagged cells, and recovering the original tagged cells for further study. Specifically, cells are tagged with a DNA construct encoding a barcode sequence comprising a guide sequence. Barcoded cells can then be recovered using a reporter construct having CRISPR target sequences specific for the cell having a barcode of interest.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 16, 2023
    Inventors: Pratiti Bandopadhayay, Rameen Beroukhim, Paul Blainey, David Feldman, Cory Johannessen, Funien Tsai
  • Methods and compositions for studying cell evolution
    Patent number: 11547614
    Abstract: The subject matter disclosed herein is generally directed to methods and compositions for tagging cells of interest, tracking evolution of the tagged cells, and recovering the original tagged cells for further study. Specifically, cells are tagged with a DNA construct encoding a barcode sequence comprising a guide sequence. Barcoded cells can then be recovered using a reporter construct having CRISPR target sequences specific for the cell having a barcode of interest.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: January 10, 2023
    Assignees: THE BROAD INSTITUTE, INC., DANA-FARBER CANCER INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Pratiti Bandopadhayay, Rameen Beroukhim, Paul Blainey, David Feldman, Cory Johannessen, Funien Tsai
  • AFFINITY-BASED MULTIPLEXING FOR LIVE-CELL MONITORING OF COMPLEX CELL POPULATIONS
    Publication number: 20220228168
    Abstract: Compositions and methods for inducing and isolating virus-like particles (VLPs), and for allowing real-time assessment of VLP-captured analytes obtained from targeted living mammalian cells, are provided.
    Type: Application
    Filed: April 28, 2020
    Publication date: July 21, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Jacob Borrajo, Paul Blainey, Mohamad Najia, Hong Anh Anna Le, FuNien Tsai
  • METHODS AND COMPOSITIONS FOR STUDYING CELL EVOLUTION
    Publication number: 20210180058
    Abstract: The subject matter disclosed herein is generally directed to methods and compositions for tagging cells of interest, tracking evolution of the tagged cells, and recovering the original tagged cells for further study. Specifically, cells are tagged with a DNA construct encoding a barcode sequence comprising a guide sequence. Barcoded cells can then be recovered using a reporter construct having CRISPR target sequences specific for the cell having a barcode of interest.
    Type: Application
    Filed: October 31, 2018
    Publication date: June 17, 2021
    Inventors: Pratiti BANDOPADHAYAY, Rameen BEROUKHIM, Paul BLAINEY, David FELDMAN, Cory JOHANNESSEN, Funien TSAI