Patents by Inventor Furn F. Knapp, Jr.
Furn F. Knapp, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7435399Abstract: A method of producing and purifying promethium-147 including the steps of: irradiating a target material including neodymium-146 with neutrons to produce promethium-147 within the irradiated target material; dissolving the irradiated target material to form an acidic solution; loading the acidic solution onto a chromatographic separation apparatus containing HDEHP; and eluting the apparatus to chromatographically separate the promethium-147 from the neodymium-146.Type: GrantFiled: September 8, 2006Date of Patent: October 14, 2008Assignee: UT-Battelle, LLCInventors: Furn F Knapp, Jr., Rose A Boll, Saed Mirzadeh
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Patent number: 6804319Abstract: A new composition of matter includes 195mPt characterized by a specific activity of at least 30 mCi/mg Pt, generally made by method that includes the steps of: exposing 193Ir to a flux of neutrons sufficient to convert a portion of the 193Ir to 195mPt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce 195mPt.Type: GrantFiled: November 20, 2003Date of Patent: October 12, 2004Assignee: UT-Battelle, LLCInventors: Saed Mirzadeh, Miting Du, Arnold L. Beets, Furn F. Knapp, Jr.
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Patent number: 6751280Abstract: A method of preparing high-specific-activity 195mPt includes the steps of: exposing 193Ir to a flux of neutrons sufficient to convert a portion of the 193Ir to 195mPt to form an irradiated material; dissolving the irradiated material to form an intermediate solution comprising Ir and Pt; and separating the Pt from the Ir by cation exchange chromatography to produce 195mPt.Type: GrantFiled: August 12, 2002Date of Patent: June 15, 2004Assignee: UT-Battelle, LLCInventors: Saed Mirzadeh, Miting Du, Arnold L. Beets, Furn F. Knapp, Jr.
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Patent number: 6716353Abstract: A method of separating lutetium from a solution containing Lu and Yb, particularly reactor-produced 177Lu and 177Yb, includes the steps of: providing a chromatographic separation apparatus containing LN resin; loading the apparatus with a solution containing Lu and Yb; and eluting the apparatus to chromatographically separate the Lu and the Yb in order to produce high-specific-activity 177Yb.Type: GrantFiled: October 30, 2002Date of Patent: April 6, 2004Assignee: UT-Battelle, LLCInventors: Saed Mirzadeh, Miting Du, Arnold L. Beets, Furn F. Knapp, Jr.
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Patent number: 5774782Abstract: A .sup.99 Mo/.sup.99m Tc generator system includes a sorbent column loaded with a composition containing .sup.99 Mo. The sorbent column has an effluent end in fluid communication with an anion-exchange column for concentrating .sup.99m Tc eluted from the sorbent column.A method of preparing a concentrated solution of .sup.99m Tc includes the general steps of:a. providing a sorbent column loaded with a composition containing .sup.99 Mo, the sorbent column having an effluent end in fluid communication with an anion-exchange column;b. eluting the sorbent column with a salt solution to elute .sup.99m Tc from the sorbent and to trap and concentrate the eluted .sup.99m Tc on the ion-exchange column; andc. eluting the concentrated .sup.99m Tc from the ion-exchange column with a solution comprising a reductive complexing agent.Type: GrantFiled: May 22, 1996Date of Patent: June 30, 1998Assignee: Lockheed Martin Energy Systems, Inc.Inventors: Saed Mirzadeh, Furn F. Knapp, Jr., Emory D. Collins
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Patent number: 5275802Abstract: A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form.Type: GrantFiled: June 12, 1992Date of Patent: January 4, 1994Assignee: Martin Marietta Energy Systems, Inc.Inventors: Furn F. Knapp, Jr., Edward C. Lisic, Saed Mirzadeh, Alvin P. Callahan
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Patent number: 5186913Abstract: A generator system for providing a carrier-free radioisotope in the form of an acid comprises a chromatography column in tandem fluid connection with an ion exchange column, the chromatography column containing a charge of a radioactive parent isotope. The chromatography column, charged with a parent isotope, is eluted with an alkali metal salt solution to generate the radioisotope in the form of an intermediate solution, which is passed through the ion-exchange column to convert the radioisotope to a carrier-free acid form.Type: GrantFiled: April 26, 1991Date of Patent: February 16, 1993Assignee: Martin Marietta Energy Systems, Inc.Inventors: Furn F. Knapp, Jr., Edward C. Lisic, Saed Mirzadeh, Alvin P. Callahan
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Patent number: 4914215Abstract: Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation of regional blood flow by radioimaging of the brain.Type: GrantFiled: August 25, 1989Date of Patent: April 3, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mark M. Goodman, Furn F. Knapp, Jr.
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Patent number: 4900539Abstract: Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation or regional blood flow by radioimaging of the brain.Type: GrantFiled: December 22, 1988Date of Patent: February 13, 1990Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mark M. Goodman, Furn F. Knapp, Jr.
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Patent number: 4826966Abstract: A radioiodinated branched carbohydrate for tissue imaging. Iodine-123 is stabilized in the compound by attaching it to a vinyl functional group that is on the carbohydrate. The compound exhibits good uptake and retention and is promising in the development of radiopharmaceuticals for brain, heart and tumor imaging.Type: GrantFiled: March 31, 1988Date of Patent: May 2, 1989Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mark M. Goodman, Furn F. Knapp, Jr.
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Patent number: 4789542Abstract: A radioiodinated branched carbohydrate for tissue imaging. Iodine-123 is stabilized in the compound by attaching it to a vinyl functional group that is on the carbohydrate. The compound exhibits good uptake and retention and is promising in the development of radiopharmaceuticals for brain, heart and tumor imaging.Type: GrantFiled: April 29, 1986Date of Patent: December 6, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Mark M. Goodman, Furn F. Knapp, Jr.
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Patent number: 4764598Abstract: A class of radiolabeled compounds to be used in tissue imaging that exhibits rapid brain uptake, good brain:blood radioactivity ratios, and long retention times. The imaging agents are more specifically radioiodinated aromatic amines attached to dihydropyridine carriers, that exhibit heart as well as brain specificity. In addition to the radiolabeled compounds, classes of compounds are also described that are used as precursors and intermediates in the preparation of the imaging agents.Type: GrantFiled: March 13, 1987Date of Patent: August 16, 1988Assignee: The United States of America as represented by the Department of EnergyInventors: Prem C. Srivastava, Furn F. Knapp, Jr.
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Patent number: 4764358Abstract: A radiolabeled long chain fatty acid for heart imaging that has dimethyl branching at one of the carbons of the chain which inhibits the extent to which oxidation can occur. The closer to the carboxyl the branching is positioned, the more limited the oxidation, thereby resulting in prolonged retention of the radiolabeled compound in the heart.Type: GrantFiled: May 30, 1986Date of Patent: August 16, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Furn F. Knapp, Jr., Mark M. Goodman, Gilbert Kirsch
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Patent number: 4683123Abstract: A generator system to provide iridium-191m for clinical imaging applications comprises an activated carbon adsorbent loaded with a compound containing the parent nuclide, osmium-191. The generator, which has a shelf-life in excess of two weeks and does not require a scavenger column, can be eluted with physiologically compatible saline.Type: GrantFiled: August 26, 1985Date of Patent: July 28, 1987Assignee: The United States of America as represented by the United States Department of EnergyInventors: Furn F. Knapp, Jr., Thomas A. Butler, Claude Brihaye
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Patent number: 4523033Abstract: The compound 15-(p-[.sup.125 I]-iodophenyl)-6-tellurapentadecanoic acid is disclosed as a myocardial imaging agent having rapid and pronounced uptake, prolonged myocardial retention, and low in vivo deiodination.Type: GrantFiled: June 29, 1983Date of Patent: June 11, 1985Assignee: The United States of America as represented by the United States Department of EnergyInventors: Furn F. Knapp, Jr., Mark M. Goodman
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Patent number: 4215045Abstract: A novel class of .sup.123m Te-labeled steroids and amino acids is provided by the method of reacting a .sup.123m Te symmetric diorgano ditelluride with a hydride reducing agent and a source of alkali metal ions to form an alkali metal organo telluride. The alkali metal organo telluride is reacted with a primary halogenated steroidal side chain, amino acid, or amino acid precursor such as hydantoin. The novel compounds are useful as biological tracers and as organal imaging agents.Type: GrantFiled: June 29, 1978Date of Patent: July 29, 1980Assignee: The United States of America as represented by the United States Department of EnergyInventor: Furn F. Knapp, Jr.