Abstract: Disclosed herein are embolism protection devices that may be deployed in the peripheral arterial system for the collection of loosened or floating debris, such as embolic material dislodged during or thrombi formed as a result of a peripheral intervention, such as an angioplasty, stenting, or atherectomy. The disclosed embolism protection devices are designed to be inserted distal to lesion in a lower limb artery via one of the arteries of the foot, such as the dorsalis pedis, posterior tibialis, or peroneal (fibular) artery, and they include a compliant mesh portion supported by a compliant wire support member, and the compliant mesh portion extends to form or couples to a solid catheter portion that extends out of the body during use, and that may be coupled to a stopcock or syringe for removal of debris.

Abstract: Disclosed herein are embolism protection devices that may be deployed in the peripheral arterial system for the collection of loosened or floating debris, such as embolic material dislodged during or thrombi formed as a result of a peripheral intervention, such as an angioplasty, stenting, or atherectomy. The disclosed embolism protection devices are designed to be inserted distal to lesion in a lower limb artery via one of the arteries of the foot, such as the dorsalis pedis, posterior tibialis, or peroneal (fibular) artery, and they include a compliant mesh portion supported by a compliant wire support member, and the compliant mesh portion extends to form or couples to a solid catheter portion that extends out of the body during use, and that may be coupled to a stopcock or syringe for removal of debris.

Abstract: Disclosed herein are systems and methods for protecting a subject from embolisms during TAVR percutaneous valve procedures. Various embodiments include an intravascular embolism protection device that includes an elongated, compliant wire frame made from a material having a shape-memory function, and a mesh sleeve coupled to the compliant wire frame, the mesh material having a pore size selected to allow blood to pass therethrough while retaining potential emboli. In some embodiments, the embolism protection device has a collapsed state wherein device fits within the lumen of a deployment/retrieval catheter and an expanded state wherein the embolism protection device expands to span the width of the aorta and the distance between the aortic valve and the puncture site in the femoral artery.

Abstract: Disclosed herein are methods of traversing a chronic total occlusion (CTO) that include advancing a recanalization wire through the vasculature of the subject through a puncture site in an artery of a lower extremity towards a distal cap of the CTO, advancing the recanalization wire through the CTO until a distal tip of the recanalization wire exits the CTO via a proximal cap of the CTO, magnetically capturing the distal tip of the recanalization wire, pulling the recanalization wire through a puncture side in a femoral artery, thus externalizing the recanalization wire. Some capture wires may include a magnetic tip, such as a neodymium tip.

Abstract: Disclosed herein are embolism protection devices that may be deployed in the peripheral arterial system for the collection of loosened or floating debris, such as embolic material dislodged during or thrombi formed as a result of a peripheral intervention, such as an angioplasty, stenting, or atherectomy. The disclosed embolism protection devices are designed to be inserted distal to lesion in a lower limb artery via one of the arteries of the foot, such as the dorsalis pedis, posterior tibialis, or peroneal (fibular) artery, and they include a compliant mesh portion supported by a compliant wire support member, and the compliant mesh portion extends to form or couples to a solid catheter portion that extends out of the body during use, and that may be coupled to a stopcock or syringe for removal of debris.

Abstract: Disclosed herein are systems and methods for protecting a subject from embolisms during TAVR percutaneous valve procedures. Various embodiments include an intravascular embolism protection device that includes an elongated, compliant wire frame made from a material having a shape-memory function, and a mesh sleeve coupled to the compliant wire frame, the mesh material having a pore size selected to allow blood to pass therethrough while retaining potential emboli. In some embodiments, the embolism protection device has a collapsed state wherein device fits within the lumen of a deployment/retrieval catheter and an expanded state wherein the embolism protection device expands to span the width of the aorta and the distance between the aortic valve and the puncture site in the femoral artery.

Abstract: Embodiments provide catheter retention devices such as catheter clips that may be used to stabilize a vascular access catheter during a procedure, particularly a radial access procedure. The catheter clips may include a frame that includes a first frame member portion, a second frame member portion hingeably coupled to the first frame member portion, the first and second frame member portions defining a first aperture therebetween, and a base member extending from the second frame member; and an inner gripping membrane that includes a first inner gripping membrane portion coupled to the first frame member portion and a second inner gripping portion coupled to the second frame member portion, wherein the first and second inner gripping portions define a second aperture within the first aperture.

Abstract: Embodiments provide catheter retention devices such as catheter clips that may be used to stabilize a vascular access catheter during a procedure, particularly a radial access procedure. The catheter clips may include a frame that includes a first frame member portion, a second frame member portion hingeably coupled to the first frame member portion, the first and second frame member portions defining a first aperture therebetween, and a base member extending from the second frame member; and an inner gripping membrane that includes a first inner gripping membrane portion coupled to the first frame member portion and a second inner gripping portion coupled to the second frame member portion, wherein the first and second inner gripping portions define a second aperture within the first aperture.

Abstract: Embodiments provide adjustable vascular catheter systems suitable for use in radial access procedures. In embodiments, the adjustable catheter includes an elongated tubular member having a wall defining a proximal end, a distal end, and a main lumen extending therebetween; a first micro-lumen having a proximal end, a distal end, and a hollow lumen extending therebetween, wherein the first micro-lumen extends substantially outwardly from the catheter wall and runs in parallel with the main lumen; and a first shape wire adapted to pass within the first micro-lumen, wherein the first shape wire has a shape memory function sufficient to deflect a deflectable distal portion of the elongated tubular member. In various embodiments, the shape of the deflected distal portion may allow a user to navigate the catheter past one or more tortuosities and reach normally positioned and anomalous positioned vascular ostia. Some embodiments include second and third shape wires, each having a different shape memory function.

Abstract: Disclosed herein are systems and methods for protecting a subject from embolisms during TAVI percutaneous valve procedures, coronary bypass surgery and heart valve surgery. Various embodiments include an intravascular embolism protection device that includes an elongated, compliant frame made from a material having a shape-memory function, and a mesh material coupled to the elongated, compliant frame, the mesh material having a pore size selected to allow blood to pass therethrough while retaining potential emboli. In some embodiments, the embolism protection device has a collapsed state wherein device is configured to fit within the lumen of a support catheter and an expanded state wherein the embolism protection device is configured to cover a plurality of arterial branch ostias.