Patents by Inventor Fusao Kimizuka

Fusao Kimizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Restriction endonuclease
    Patent number: 5496717
    Abstract: A new restriction endonuclease capable of recognizing the nucleotide sequence of the following formula 1 in double stranded DNA. ##STR1## and specifically cleaving it is disclosed. The endonuclease may be made cultivating a strain of the genus Streptomyces (FERM BP-4836) capable of producing it.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: March 5, 1996
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Yoshiko Nomura, Fusao Kimizuka, Yoshizumi Ishino, Ikunoshin Kato
  • Artificial antibody
    Patent number: 5475100
    Abstract: This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: December 12, 1995
    Assignees: Fujita Health University, Takara Shuzo Co., Ltd.
    Inventors: Kimikazu Hashino, Fusao Kimizuka, Ikunoshin Kato, Yoshikazu Kurosawa, Koiti Titani, Kiyotoshi Sekiguchi
  • Polypeptides and method for preparing the same
    Patent number: 5434245
    Abstract: There is provided a polypeptide having the following formula (I'), and which polypeptide is referred to as Glu-OC and a process for the preparation thereof.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: July 18, 1995
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Nobuto Koyama, Fusao Kimizuka, Ikunoshin Kato
  • Polypeptide having human fibronectin-like cell adhesive activity
    Patent number: 5302701
    Abstract: This present invention is directed to an artificial functional polypeptide represented by the following structural formula [I]:X--(Y)m--Z [I]wherein X represents a polypeptide having cell-adhesive activity like that of human FN, Y represents a spacer, Z represents a polypeptide having fibroblast growth promoting activity like that of FGF, and m is 1 or 0. This polypeptide is particularly useful for pharmaceutical purposes.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: April 12, 1994
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Hidetaka Hashi, Fusao Kimizuka, Ikunoshin Kato, Mika Hatai, Yoshihito Yaoi
  • Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
    Patent number: 5198423
    Abstract: This invention relates to a functional polypeptide containing the binding domain of human fibronectin and the heparin-binding domain of human fibronectin.
    Type: Grant
    Filed: May 22, 1990
    Date of Patent: March 30, 1993
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Yuki Taguchi, Yoh'ichi Ohdate, Yasutoshi Kawase, Shouichi Goto, Fusao Kimizuka, Ikunoshin Kato, Ikuo Saiki, Ichiro Azuma
  • Human calpastatin-like polypeptide
    Patent number: 5189144
    Abstract: Polypeptides are provided which have a calpain inhibitory activity. The polypeptides have an activity like that of natural human calpastatin but are significantly shorter in length than natural human calpastatin. The polypeptides are suited for synthetic manufacture.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: February 23, 1993
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Kiyozo Asada, Takashi Uemori, Masahiro Endo, Fusao Kimizuka, Ikunoshin Kato
  • Restriction enzyme Sse 8387I
    Patent number: 5179016
    Abstract: The class II restriction endonuclease Sse 8387I is obtained from Streptomyces Sp 837 (FERM BP-3028). It recognizes the nucleotide sequence 5'-CCTGCA.dwnarw.GG-3' and cleaves at the position indicated by the arrow.
    Type: Grant
    Filed: May 13, 1991
    Date of Patent: January 12, 1993
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Hirokazu Kotani, Fusao Kimizuka, Ikunoshin Kato
  • Polypeptide with cell-spreading activity
    Patent number: 5136023
    Abstract: A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
    Type: Grant
    Filed: November 16, 1989
    Date of Patent: August 4, 1992
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Kimikazu Hashino, Shouichi Goto, Yasutoshi Kawase, Yoh'ichi Ohdate, Yuki Taguchi, Tatsuru Kinoshita, Fusao Kimizuka, Ikunoshin Kato
  • Polypeptide with cell-spreading activity
    Patent number: 5102988
    Abstract: A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: April 7, 1992
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Fusao Kimizuka, Shouichi Goto, Yoh'ichi Ohdate, Masamitsu Shimada, Ikunoshin Kato
  • Polypeptide with cell-spreading activity
    Patent number: 5049658
    Abstract: A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
    Type: Grant
    Filed: December 29, 1988
    Date of Patent: September 17, 1991
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Fusao Kimizuka, Tatsuru Kinoshita, Yoh'ichi Ohdate, Yuki Sugahara, Ikunoshin Kato
  • Polypeptides with cell-spreading activity
    Patent number: 5045631
    Abstract: A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: September 3, 1991
    Assignee: Takara Shuzo Co., Ltd.
    Inventors: Fusao Kimizuka, Tatsuru Kinoshita, Yoh'ichi Ohdate, Yuki Taguchi, Ikunoshin Kato