Abstract: A tooth flank machining device includes a helical teeth grinding wheel, a position adjusting unit] capable of moving a relative position of a rotational axis of the helical teeth grinding wheel to a rotational axis of a work gear, and a controlling unit having a relative position controller activating the position adjusting unit to adjust the relative position of the rotational axis of the helical teeth grinding wheel to the rotational axis of the work gear so that the helical teeth grinding wheel engages the work gear with a grinding wheel tooth flank of the helical teeth grinding wheel abutting on only one of work tooth flanks forming a tooth of the work gear, a grinding wheel rotating unit controller activating a grinding wheel rotating unit, and a torque controlling unit controller activating a rotational torque controlling unit to adjust rotational torque within a predetermined range.

Abstract: The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encoding the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.

Abstract: A tooth flank machining device includes a helical teeth grinding wheel, a position adjusting unit] capable of moving a relative position of a rotational axis of the helical teeth grinding wheel to a rotational axis of a work gear, and a controlling unit having a relative position controller activating the position adjusting unit to adjust the relative position of the rotational axis of the helical teeth grinding wheel to the rotational axis of the work gear so that the helical teeth grinding wheel engages the work gear with a grinding wheel tooth flank of the helical teeth grinding wheel abutting on only one of work tooth flanks forming a tooth of the work gear, a grinding wheel rotating unit controller activating a grinding wheel rotating unit, and a torque controlling unit controller activating a rotational torque controlling unit to adjust rotational torque within a predetermined range.

Abstract: The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.

Abstract: The present invention is to provide a polypeptide specifically inhibiting the activity of Akt (Protein Kinase B), the DNA thereof, the antibody thereof, an inhibitor of Akt activity or an antitumor agent, and the like. The polypeptide comprises polypeptides (SEQ ID NO: 1, 3, 5, 7, and 9 of the sequence listing) that contain an amino acid sequence corresponding to any of the position of amino acid residue 10-24 of human TCL1, amino acid residue 8-22 of human TCL1B, amino acid residue 5-19 of human MTCP1, and amino acid residue 9-24 of mouse or rat TCL1; and the derivatives. Further, the present invention includes DNA encording the polypeptide (SEQ ID NO: 2, 4, 6, 8 or 10 of the sequence listing), and the antibodies specifically binding to the polypeptides. The polypeptide of the present invention can be used for an inhibitor of Akt activity, an antitumor agent, or the like.

Abstract: The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of preventing or treating the tumor.

Abstract: The invention prevents or treats tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent comprising a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of preventing or treating tumor.