Patents by Inventor Fuxin Shi

Fuxin Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11857567
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: January 2, 2024
    Assignee: Decibel Therapeutics, Inc.
    Inventors: Qi-Ying Hu, John Lee, Fuxin Shi
  • Patent number: 11690870
    Abstract: Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: July 4, 2023
    Assignee: Decibel Therapeutics, Inc.
    Inventors: John Lee, John R. Soglia, Qi-Ying Hu, Fuxin Shi
  • Publication number: 20210355504
    Abstract: The invention provides AAV1 vectors that can be used to transduce multiple inner ear cell types and their use for treatment of hearing loss, deafness, tinnitus, and vestibular dysfunction.
    Type: Application
    Filed: October 11, 2019
    Publication date: November 18, 2021
    Inventors: Joseph BURNS, Kathryn ELLIS, Matthew NGUYEN, Adam PALERMO, Gabriela PREGERNIG, Fuxin SHI, Jonathon WHITTON
  • Publication number: 20210308176
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 7, 2021
    Inventors: Qi-Ying HU, John LEE, Fuxin SHI
  • Publication number: 20210290686
    Abstract: This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.
    Type: Application
    Filed: February 19, 2021
    Publication date: September 23, 2021
    Inventors: Albert Edge, Fuxin Shi
  • Patent number: 11071751
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: July 27, 2021
    Assignee: Decibel Therapeutics, Inc.
    Inventors: Qi-Ying Hu, John Lee, Fuxin Shi
  • Publication number: 20210038640
    Abstract: Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 11, 2021
    Inventors: John LEE, John R. SOGLIA, Qi-Ying HU, Fuxin SHI
  • Publication number: 20200338119
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Application
    Filed: July 13, 2020
    Publication date: October 29, 2020
    Inventors: Qi-Ying HU, John LEE, Fuxin SHI
  • Patent number: 10813947
    Abstract: Disclosed herein are methods for otoprotection against platinum-based antineoplastic agents by administering a thiosulfate salt to a subject in need thereof. Typically, the thiosulfate salt is administered to the subject scheduled to be administered a platinum-based antineoplastic agent within 4 hours. Alternatively, the thiosulfate salt is administered within 7 hours after the administration of a platinum-based neoplastic agent.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: October 27, 2020
    Assignee: Decibel Therapeutics, Inc.
    Inventors: John Lee, John R. Soglia, Qi-Ying Hu, Fuxin Shi
  • Patent number: 10709732
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: July 14, 2020
    Assignee: Decibel Therapeutics, Inc.
    Inventors: Qi-Ying Hu, John Lee, Fuxin Shi
  • Patent number: 10533037
    Abstract: The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution, dialysis, centrifugation, high temperature and high pressure treatment and freeze-drying. A method of preparing silk fibroin microspheres with polyethylene glycol comprises mixing a silk fibroin solution of 1-30 wt % with a PEG solution of 10-60 w % and incubating the resulting solution. A controlled-release or sustained-release silk fibroin gel formulation includes a gel-state carrier and a drug dispersed/adsorbed therein, the carrier is a silk fibroin gel formed by blending with LMW-PEG.
    Type: Grant
    Filed: March 25, 2015
    Date of Patent: January 14, 2020
    Assignees: SIMATECH INCORPORATION, TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, Jian Liu, Jianbing Wu, Cheng Qian, Zhaozhu Zheng, Shaozhe Guo, Fuxin Shi, David Kaplan
  • Publication number: 20190336524
    Abstract: Hypertonic pharmaceutical compositions are disclosed. The hypertonic pharmaceutical compositions contain an anti-platinum chemoprotectant agent and a gelling agent. Also disclosed are methods of medical use of the hypertonic pharmaceutical compositions.
    Type: Application
    Filed: July 19, 2019
    Publication date: November 7, 2019
    Inventors: Qi-Ying HU, John LEE, Fuxin SHI
  • Publication number: 20190192575
    Abstract: This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.
    Type: Application
    Filed: November 2, 2018
    Publication date: June 27, 2019
    Inventors: Albert Edge, Fuxin Shi
  • Patent number: 10143711
    Abstract: This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: December 4, 2018
    Assignee: Massachusetts Eye & Ear Infirmary
    Inventors: Albert Edge, Fuxin Shi
  • Publication number: 20170107264
    Abstract: The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution, dialysis, centrifugation, high temperature and high pressure treatment and freeze-drying. A method of preparing silk fibroin microspheres with polyethylene glycol comprises mixing a silk fibroin solution of 1-30 wt % with a PEG solution of 10-60 w % and incubating the resulting solution. A controlled-release or sustained-release silk fibroin gel formulation includes a gel-state carrier and a drug dispersed/adsorbed therein, the carrier is a silk fibroin gel formed by blending with LMW-PEG.
    Type: Application
    Filed: March 25, 2015
    Publication date: April 20, 2017
    Inventors: Xiaoqin WANG, Jian LIU, Jianbing WU, Cheng QIAN, Zhaozhu ZHENG, Shaozhe GUO, Fuxin SHI
  • Publication number: 20110305674
    Abstract: This disclosure relates to methods and compositions for modulating (e.g., increasing) Atoh1 activity (e.g., biological activity) and/or expression (e.g., transcription and/or translation) in vivo and/or in vitro, e.g., in a biological cell and/or in a subject. The methods and compositions described herein can be used in the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression in a biological cell.
    Type: Application
    Filed: November 24, 2009
    Publication date: December 15, 2011
    Applicant: MASSACHUSETTS EYE & EAR INFIRMARY
    Inventors: Albert Edge, Fuxin Shi