Patents by Inventor G. Brock

G. Brock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240417699
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Application
    Filed: June 27, 2024
    Publication date: December 19, 2024
    Inventors: Peter L. COLLINS, Cyril LE NOUEN, Linda G. BROCK, Ursula J. BUCHHOLZ, Joshua Marc DINAPOLI, Steffen MUELLER, Eckard WIMMER
  • Publication number: 20240392317
    Abstract: Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
    Type: Application
    Filed: August 9, 2024
    Publication date: November 28, 2024
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Shirin Munir, Linda G. Brock, Ursula J. Buchholz, Peter L. Collins
  • Patent number: 12071632
    Abstract: Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: August 27, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Shirin Munir, Linda G. Brock, Ursula J. Buchholz, Peter L. Collins
  • Patent number: 12054749
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: August 6, 2024
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, The Research Foundation for the State University of New York
    Inventors: Peter L. Collins, Cyril Le Nouen, Linda G. Brock, Ursula J. Buchholz, Joshua Marc Dinapoli, Steffen Mueller, Eckard Wimmer
  • Publication number: 20220325252
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Application
    Filed: June 2, 2022
    Publication date: October 13, 2022
    Inventors: Peter L. COLLINS, Cyril LE NOUEN, Linda G. BROCK, Ursula J. BUCHHOLZ, Joshua Marc DINAPOLI, Steffen MUELLER, Eckard WIMMER
  • Patent number: 11371024
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: June 28, 2022
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • Publication number: 20210189425
    Abstract: Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.
    Type: Application
    Filed: April 23, 2019
    Publication date: June 24, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Shirin Munir, Linda G. Brock, Ursula J. Buchholz, Peter L. Collins
  • Publication number: 20180208906
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 26, 2018
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • Patent number: 9957486
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 1, 2018
    Assignees: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, The Research Foundation For the State University of New York
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • Patent number: 9435610
    Abstract: A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: September 6, 2016
    Assignee: Leupold & Stevens, Inc.
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge, Richard Bradley Brumfield
  • Patent number: 9291192
    Abstract: A connecting rod of an internal combustion engine, that includes a large bore, and an interior bore surface. The current art uses soft metal bearing surfaces to reduce wear, and friction between the connecting rod inner diameter and the crankshaft journal surface. The soft metal bearing surface is a separate component of the engine. In this invention the large bore end interior diameter is coated with a hard material to reduce, or eliminate wear. The hard material is a metal or metal alloy applied to the inner diameter by a thermal spray method. A relatively soft polymer material can also be applied to the interior diameter surface of the con-rod bore. The relatively softer polymer acts as a first and sometimes a consumable layer, and applied over the thermal sprayed hard layer. The polymer layer is often used in conjunction with the sprayed metal layer.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: March 22, 2016
    Assignee: Mahle International GmbH
    Inventors: Ronald G. Brock, II, Viviane Morais, Joachim Wagenblast, David Maloney
  • Publication number: 20150368622
    Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 24, 2015
    Inventors: Peter L. Collins, Cyril Le Nouën, Linda G. Brock, Ursula J. Buchholz, Joshua Marc DiNapoli, Steffen Mueller, Eckard Wimmer
  • Publication number: 20150354921
    Abstract: A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system.
    Type: Application
    Filed: April 24, 2015
    Publication date: December 10, 2015
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge
  • Patent number: 9038307
    Abstract: A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: May 26, 2015
    Assignee: Leupold & Stevens, Inc.
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge
  • Publication number: 20140373424
    Abstract: A reticle of a projectile-weapon aiming system such as a riflescope includes first and second series of secondary aiming marks spaced apart below a primary aiming point, the first and second series providing holdover aiming points for regularly incrementing target distances for respective subsonic and supersonic .300 AAC Blackout ammunition, or other differing types of ammunition, without requiring adjustment of the optics or settings of the aiming system.
    Type: Application
    Filed: November 20, 2013
    Publication date: December 25, 2014
    Applicant: Leupold & Stevens, Inc.
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge
  • Publication number: 20130064490
    Abstract: A sliding bearing surface may have at least one thermal spray coating applied to the bearing surface to form a sliding bearing lining layer. A method of forming the sliding bearing lining, the method comprising applying the thermal spray coating to the bearing surface uses a thermal spray technique.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 14, 2013
    Inventors: Ronald G. Brock, II, Daniel M. Lonowski, David Domanchuk, Thomas Stong
  • Patent number: 8060450
    Abstract: An interactive, computer-implemented system for providing a comparison of at least two real estate properties is provided. The system includes a database that stores a plurality of data relating to real estate properties. The data includes at least one of address data, ownership data, size data, geographic location data and monetary value data. An interface system enables a system user to input a request for a comparison of at least a portion of the data for at least two of the real estate properties. The request includes information sufficient to identify the real estate properties to be compared. A processor uses the information to obtain a comparison of the data relating to the real estate properties. A delivery system provides to the system user a comparison of the data relating to the real estate properties.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: November 15, 2011
    Assignee: Pierce-Eislen, Inc.
    Inventor: Ronald G. Brock, Sr.
  • Patent number: 7974930
    Abstract: An interactive, computer-implemented system for providing a comparison of at least two real estate properties is provided. The system includes a database that stores a plurality of data relating to real estate properties. The data includes at least one of address data, ownership data, size data, geographic location data and monetary value data. An interface system enables a system user to input a request for a comparison of at least a portion of the data for at least two of the real estate properties. The request includes information sufficient to identify the real estate properties to be compared. A processor uses the information to obtain a comparison of the data relating to the real estate properties. A delivery system provides to the system user a comparison of the data relating to the real estate properties.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: July 5, 2011
    Assignee: Pierce-Eislen, Inc.
    Inventor: Ronald G. Brock, Sr.
  • Patent number: D709588
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: July 22, 2014
    Assignee: Leupold & Stevens, Inc.
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge
  • Patent number: D753785
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: April 12, 2016
    Assignee: Leupold & Stevens, Inc.
    Inventors: Robert Silvers, Martin Koornneef, Raymond G. Brock, Stephen R. Hodge, Richard Bradley Brumfield