Patents by Inventor G. Davis Harris

G. Davis Harris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolinone derivatives as protein kinase/phosphatase inhibitors
    Publication number: 20020052369
    Abstract: The present invention relates to certain 2-indolinone compounds which modulate the activity of protein kinases (“PKs”) and phosphatases. The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Application
    Filed: June 4, 2001
    Publication date: May 2, 2002
    Inventors: Peng Cho Tang, G. Davis Harris, Xiaoyuan Li
  • Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
    Patent number: 6376529
    Abstract: The present invention relates to a class of indolylquinone compounds that inhibit GRB-2 adaptor protein function, pharmaceutical compositions comprising these compounds, and methods for ameliorating the symptoms of cell proliferative disorders associated with GRB-2 adaptor protein function using these compounds. The present invention further relates to methods for treating insulin-related disorders, such as diabetes, insulin resistance, insulin deficiency and insulin allergy, and for ameliorating the symptoms of insulin-related disorders, using certain indolylquinone compounds and pharmaceutical compositions thereof. The present invention also relates to novel synthetic methods for the preparation of mono- and bis-indolylquinone compounds.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: April 23, 2002
    Inventors: Peng Cho Tang, Gerald McMahon, G. Davis Harris, Jr., Ken Lipson
  • 2-indolinone derivatives as modulators of protein kinase activity
    Publication number: 20020028840
    Abstract: The present invention relates to novel imidazoly 2-indolinones and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Application
    Filed: July 6, 2001
    Publication date: March 7, 2002
    Inventors: Peng Cho Tang, Li Sun, Gerald McMahon, G. Davis Harris
  • Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions
    Publication number: 20020016353
    Abstract: The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.
    Type: Application
    Filed: May 14, 2001
    Publication date: February 7, 2002
    Inventors: Peng Cho Tang, Gerald McMahon, G. Davis Harris
  • Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions
    Patent number: 6239161
    Abstract: The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of complexing with a member of the SH2-and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: May 29, 2001
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Gerald McMahon, G. Davis Harris
  • Synthetic methods for the preparation of indolylquinones and mono- and bis-indolylquinones prepared therefrom
    Patent number: 6110957
    Abstract: The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono-indolylquinones of high purity and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: August 29, 2000
    Assignee: Sugen, Inc.
    Inventors: Peng C. Tang, G. Davis Harris, Jr.
  • Methods and compositions for inhibition of adaptor protein/tyrosine kinase interactions
    Patent number: 6090838
    Abstract: The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: July 18, 2000
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Gerald McMahon, G. Davis Harris
  • Thiazole compounds and methods of modulating signal transduction
    Patent number: 6080772
    Abstract: The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such compounds to treat various disease states including diabetes mellitus.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: June 27, 2000
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, John Yudhistir Ramphal, G. Davis Harris, Jr., Asaad S. Nematalla
  • Synthetic methods for the preparation of indolyquinones
    Patent number: 5786488
    Abstract: The present invention relates to novel synthetic methods for the preparation of indolylquinones. The methods of the present invention are directed to synthetic reactions involving indoles and halo-quinones in solvent and in the presence of a metal carbonate. The invention also relates to bis- and mono-indolylquinones of high purity and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: July 28, 1998
    Assignee: Sugen, Inc.
    Inventors: Peng C. Tang, G. Davis Harris
  • Method and compositions for inhibition of adaptor protein/tyrosine kinase interactions
    Patent number: 5780496
    Abstract: The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of completing with a member of the SH2- and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: July 14, 1998
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Gerald McMahon, G. Davis Harris