Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: A method for establishing signal and power communication between a surgical instrument and a staple cartridge is disclosed.

Abstract: Various techniques and apparatus permit fabrication of superconductive circuits. A superconducting integrated circuit comprising a superconducting stud via, a kinetic inductor, and a capacitor may be formed. Forming a superconducting stud via in a superconducting integrated circuit may include masking with a hard mask and masking with a soft mask. Forming a superconducting stud via in a superconducting integrated circuit may include depositing a dielectric etch stop layer. Interlayer misalignment in the fabrication of a superconducting integrated circuit may be measured by an electrical vernier. Interlayer misalignment in the fabrication of a superconducting integrated circuit may be measured by a chain of electrical verniers and a Wheatstone bridge. A superconducting integrated circuit with three or more metal layers may include an enclosed, matched, on-chip transmission line. A metal wiring layer in a superconducting integrated circuit may be encapsulated.

Abstract: In a threat management platform, a number of endpoints log events in an event data recorder. A local agent filters this data and feeds a filtered data stream to a central threat management facility. The central threat management facility can locally or globally tune filtering by local agents based on the current data stream, and can query local event data recorders for additional information where necessary or helpful in threat detection or forensic analysis. The central threat management facility also stores and deploys a number of security tools such as a web-based user interface supported by machine learning models to identify potential threats requiring human intervention and other models to provide human-readable context for evaluating potential threats.

Abstract: A surgical guide includes a body including a beveled distal surface configured to being placed against a side of a foot and a proximal surface. The body includes at least one channel that extends between the beveled distal surface and the proximal surface of the body. At least one K-wire is receivable in the at least one channel and is configured to being received in a metatarsal and a capital fragment of the foot. The guide includes a handle, and a preset angle is defined between a longitudinal axis of the body and the beveled distal surface of the body. The preset angle is between approximately 25° and approximately 30°.

Abstract: An interactive control unit is disclosed. The interactive control unit includes an interactive touchscreen display, an interface configured to couple the control unit to a surgical hub, a processor, and a memory coupled to the processor. The memory stores instructions executable by the processor to receive input commands from the interactive touchscreen display located inside a sterile field and transmit the input commands to the surgical hub to control devices coupled to the surgical hub located outside the sterile field.

Abstract: Monitoring rotating machine position using a resolver having an input primary and one or more output secondaries magnetically coupled to the input primary. The method includes exciting the input primary with an exciter input signal, causing a first scaled version of the exciter input signal to appear in a first output secondary. Output from the first output secondary is collected. The collected output from the first output secondary is demodulated to recover gain from the input primary.

Abstract: Quantum processors having qubits with tunable capacitance are provided. The qubits include Josephson junctions shunted by capacitors and are tunably coupled to capacitance loops such that the resonant frequencies of the qubits and capacitance loops avoid entanglement with each other. Methods for tuning the capacitance of such qubits by varying the coupler's coupling strength are provided. These methods include methods for calibrating qubits' capacitance.

Abstract: A method for adjusting control parameters of a clip applier using a surgical hub is disclosed. The method comprises gathering data during a first surgical procedure, evaluating the gathered data to determine the appropriate operation of a clip applier in a subsequent surgical procedure, gathering data during the operation of the clip applier in the subsequent surgical procedure, determining if the operation of the clip applier needs to be adjusted based on the data gathered during the subsequent surgical procedure, and adjusting the operation of the clip applier based on the data gathered during the subsequent surgical procedure.

Abstract: This disclosure relates to systems and methods for repairing bone deformities. The systems may include one or more guides for positioning instruments relative to bones and/or joints.

Abstract: A door hinge comprising: a frame mount configured to be mounted to a door frame which is disposed about a doorway; and a door mount configured to be mounted to a door which is to selectively close off the doorway; wherein the door mount is pivotally connected to the frame mount about an axis of rotation, and further wherein the door hinge is configured such that when the frame mount is mounted to a door frame, and when the door mount is mounted to a door, the axis of rotation of the door hinge is disposed outwards of the point of attachment of the door hinge to the door frame, and laterally outboard of the doorway.

Abstract: Methods of making a top-plane connection in an electro-optic device and devices including such connections. A through hole is created through a rear substrate to provide a connection between a conductor coupled to the rear substrate and a light-transmissive conductive layer coupled to a top transparent substrate. The hole is subsequently filled with a top-plane connection material that provides an electrical connection between the conductor and the light-transmissive conductive layer, but does not provide an electrical connection between a separate rear conductive layer and the light-transmissive conductor.

Abstract: A logical qubit, a quantum processor, and a method of performing an operation on the logical qubit are discussed. The logical qubit includes first and second tunable couplers and a plurality of fixed couplers, with at least one fixed coupler providing four physical qubit interaction. The first and second tunable couplers and the fixed couplers enforce even parity in any connected qubits. The logical qubit has a plurality of physical qubits with qubits connected to the first tunable coupler and a first fixed coupler, qubits connected to the second tunable coupler and a second fixed coupler, and qubits connected between the first fixed coupler and the second fixed coupler. Each fixed coupler is connected to at least two physical qubits and at least two paths connect the first tunable coupler and the second tunable coupler, with one path communicating with a microwave line.

Abstract: An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another.

Abstract: A method of manufacturing a segmented electro-optic display includes providing an electro-optic display stack including a first substrate layer, a first layer of light-transmissive electrically-conductive material, a layer of electro-optic material, a lamination adhesive, a second layer of light-transmissive electrically-conductive material, and a second substrate layer. The method also includes forming electrically-isolated conductive segments on the second layer of electrically-conductive material using a laser etching process that includes irradiating the second substrate and second electrically-conductive layers at multiple locations with a laser emitting light within a first range of wavelengths. The second substrate layer is transmissive of light within the first range of wavelengths, and the light-transmissive electrically-conductive material is substantially absorptive of light within the first range of wavelengths.

Abstract: Quantum processors having qubits with tunable capacitance are provided. The qubits include Josephson junctions shunted by capacitors and are tunably coupled to capacitance loops such that the resonant frequencies of the qubits and capacitance loops avoid entanglement with each other. Methods for tuning the capacitance of such qubits by varying the coupler's coupling strength are provided. These methods include methods for calibrating qubits' capacitance.

Abstract: A polymeric film includes a plurality of tapered microcells containing a dispersion of a first group and a second group of charged particles. The first group and second group of charged particles having opposite charge polarities. The tapered microcells include a wall and at least a portion of the wall is configured to repel the first group of charged particles. Also provided is a method of making a laminate for an electrophoretic display comprising embossing a plurality of tapered microcells through a layer of polymeric film and into a release sheet to form an embossed film; laminating the embossed film to a layer of conductive material on a protective sheet to form a laminated film; removing the release sheet from the polymeric film to form an opening to an interior of each microcell of the laminated film; filling the microcells with a dispersion fluid; and sealing the microcells.

Abstract: A parking space management system includes a bistable reflective display, such as an electrophoretic display, which is sunlight-readable and only requires power when the information on the display is updated. One or more detectors are configured to determine the presence of an object within a bounded space, such as a parking space, and communicate that status to the bistable reflective display, thereby causing the bistable reflective display to show the presence of an object within the bounded space to an observer. Such a system is easy to implement and will save drivers' time because they don't have to hunt for a parking spot. Such a system also reduces tailpipe emissions because it is not necessary to drive up and down multiple aisles of cars looking for an open parking spot.

Abstract: Systems and methods for improving the performance of dilution refrigeration systems are described. Filters and traps employed in the helium circuit of a dilution refrigerator may be modified to improve performance. Some traps may be designed to harness cryocondensation as opposed to cryoadsorption. A cryocondensation trap employs a cryocondensation surface having a high thermal conductivity and a high specific heat with a binding energy that preferably matches at least one contaminant but does not match helium. Multiple traps may be coupled in series in the helium circuit, with each trap designed to trap a specific contaminant or set of contaminants. Both cryocondensation and cryoadsorption may be exploited among multiple traps.

Abstract: An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another.